A clinicostatistical study of 151 patients with salivary gland tumors

Oobu, Kazunari; Matsunaga, Kazuhide; Kawano, Eiko; Mitate, Eiji; Suzuki, Hiroyoshi; Kobayashi, Ieyoshi; Kiyoshima, Tamotsu; Nakamura, Seiji

doi:10.5794/jjoms.52.393

Cited by 10 publications

(3 citation statements)

References 4 publications

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“…In the minor salivary gland, these tumors most often arise from the palate. CXPA from the buccal mucosa is extremely rare, and only four cases [2][3][4][5] have been reported (Table 1). Many cases of CXPA have been reported in women [2,3,6].…”

Section: Discussionmentioning

confidence: 99%

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A Case of Carcinoma Ex Pleomorphic Adenoma in the Buccal Mucosa: Review of the Literature

Nakamura

Inui

Matsumura

et al. 2011

J. Maxillofac. Oral Surg.

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We present a case of carcinoma ex pleomorphic adenoma on the right buccal mucosa in a 52-year-old Japanese woman. Based on the histopathology, the excised tumor was the non-invasive type, but the majority of the tumor consisted of poorly-differentiated adenocarcinoma cells. We performed proton radiation after the surgery. The patient was well, without evidence of disease, 48 months after surgery. Carcinoma ex pleomorphic adenoma in the buccal mucosa has been reported in only four cases during the past twenty years. Therefore, our case was comparatively rare.

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Section: Discussionmentioning

confidence: 99%

“…CXPA from the buccal mucosa is extremely rare, and only four cases [2][3][4][5] have been reported (Table 1). Many cases of CXPA have been reported in women [2,3,6]. The onset of CXPA has been reported to occur at 60-80 years of age [6], with an average age of 60 years [7,8].…”

Section: Discussionmentioning

confidence: 99%

A Case of Carcinoma Ex Pleomorphic Adenoma in the Buccal Mucosa: Review of the Literature

Nakamura

Inui

Matsumura

et al. 2011

J. Maxillofac. Oral Surg.

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“…Among all salivary gland tumors, approximately 40% are malignant ones, and when the ACC are combined with mucoepidermoid carcinoma the total amounts to 80% or more. ACCs occur mainly in the palatine gland in approximately 35% and in the sublingual gland in approximately 30% (26). ACC has characteristics of a tendency towards permeation and intensive recurrence, and prognosis is generally poor.…”

Section: Discussionmentioning

confidence: 99%

Mutation of the p16/CDKN2 gene and loss of heterozygosity in malignant mucosal melanoma and adenoid cystic carcinoma of the head and neck

Suzuki

Onda²,

Yamamoto³

et al. 2007

Int J Oncol

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Abstract. The purpose of this study was to investigate the molecular biological characteristics of malignant mucosal melanoma (MMM) and adenoid cystic carcinoma (ACC) of the head and neck. We analyzed the common genetic abnormalities that may help to identify the loci in the genes involved in the development of MMM and ACC of the head and neck by PCR-LOH on chromosomes 1p, 6q, 9p, 10q, 11q, 12q, 17p, and 19q. LOH was observed in 6 of 12 cases of MMM and in 12 of 15 cases of ACC informative for at least one of the loci analyzed. One distinct deleted region was identified at chromosome 9p21. In addition, to identify a possible involvement of p16/CDKN2 PCR-SSCP and auto-DNA sequence analysis were also performed to detect any mutation of the p16/CDKN2. Particularly, 2 missense mutations were detected in codon 225 and 226, both in MMM and ACC. There were mutational hot spots in the p16/CDKN2 gene. These results suggested that mutation of the p16/CDKN2 gene was a common factor in the development of human MMMs and ACCs, while this gene may be correlated with development and/or progression of a subtype and play a role in the oncogenesis of these cancers.

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