A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy

Bikhazi, George B.; Snabes, Michael C.; Bajwa, Zahid H.; Davis, Derek J; Lecomte, D.; Traylor, Louise; Hubbard, Richard C.

doi:10.1016/j.ajog.2004.05.006

Cited by 40 publications

(28 citation statements)

References 19 publications

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“…Parecoxib did not modify these parameters; especially, it did not raise blood pressure further, which is part of the undesired side effects of longer use of COX-2 inhibitors (17,25,34,35). In comparison with recent findings of Nussmeier who described an increased incidence of cardiovascular effects after the use of parecoxib/valdecoxib for 10 days, no cardiovascular effects could be found in this intra-arterial, single-shot scheme of our model (28).…”

Section: Discussioncontrasting

confidence: 74%

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Effects of Intrarenal Administration of the Cox-2 Inhibitor Parecoxib During Porcine Suprarenal Aortic Cross-Clamping

Hauser

Fröba²,

Bracht³

et al. 2005

Shock

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The aim of this study was to investigate the effects of intrarenal administration of the cyclooxygenase-2 inhibitor parecoxib during suprarenal aortic cross-clamping. In a prospective, controlled, blinded, randomized manner, 16 anesthetized and mechanically ventilated pigs were instrumented to measure systemic and right kidney hemodynamics, oxygen exchange, and metabolism. During 45 min of suprarenal aortic cross-clamping, animals received 40 mg of parecoxib (n = 8) or vehicle (n = 8) infused continuously into the right renal artery. Hemodynamic and metabolic data, right kidney venous blood, as well as urine samples were obtained before clamping, as well as before and 75 and 195 min after declamping. Clamping transiently increased mean arterial pressure in both groups. Systemic and renal blood flow did not differ between the pre- and postclamping measurements or between groups. Parecoxib attenuated the otherwise significant fall in right kidney creatinine clearance (controls: from 45 [7;111] to 17 [9;22] mL/min; parecoxib: from 39 [3;59] to 27 [11;45] mL/min, P = 0.039 and P = 0.297, respectively versus before clamping, P = 0.021 versus controls at 195 min) and prevented the impairment of renal lactate balance observed in the control group (controls: from 0.5 [-0.8;3.5] to 0.2 [-0.2;0.6] mumol/kg/min; parecoxib: from 0.6 [-1.0;2.0] to 0.4 [-1.2;0.6] mumol/kg/min, P = 0.038 and P = 0.285, respectively, versus before clamping). In conclusion, intrarenal parecoxib infusion beneficially influenced kidney function in this clinically relevant model of suprarenal aortic cross-clamping.

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Section: Discussioncontrasting

confidence: 74%

“…However, these results were obtained during longer ($10 days) use of these drugs (25,26), whereas there are several papers describing parecoxib as a safe drug during short-term administration for postoperative pain relief (27,28).…”

Section: Introductionmentioning

confidence: 48%

Effects of Intrarenal Administration of the Cox-2 Inhibitor Parecoxib During Porcine Suprarenal Aortic Cross-Clamping

Hauser

Fröba²,

Bracht³

et al. 2005

Shock

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“…25,26 The efficacy of parecoxib for noncardiac postoperative analgesia is well described. [3][4][5][6] Parecoxib is rapidly converted to valdecoxib by hydrolysis after administration, 1,2 and analgesia is said to begin within 15 minutes of an intravenous or intramuscular injection. Valdecoxib is then extensively metabolized and most of its metabolites are excreted in the urine; this metabolism includes cytochrome P450 iso-enzymes 3A4 and 2C9.…”

Section: Discussionmentioning

confidence: 99%

“…P arecoxib sodium is a potent parenteral, sulphonamide containing, selective cyclo-oxygenase-2 (COX-2) inhibitor, a 'pro-drug' of the active agent valdecoxib, 1,2 with comparable analgesic activity to ketorolac tromethamine, 3,4 which it has replaced in Australia and many other countries by the intravenous or intramuscular route and in limited dose for postoperative opioid-sparing analgesia in noncardiac surgical patients. 5,6 The European Medicines Agency granted a marketing authorization, valid throughout the European Union, for parecoxib sodium in March 2002.…”

Section: Introductionmentioning

confidence: 99%

Daily Subcutaneous Parecoxib Injection for Cancer Pain: An Open Label Pilot Study

Kenner

Bhagat

Fullerton

2015

Journal of Palliative Medicine

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“…Laparatomi ginekologis mempunyai risiko nyeri pascaoperatif derajat sedang sampai berat, 1,2 sehingga memerlukan penatalaksanaan nyeri pascaoperatif yang baik untuk mendapatkan keluaran yang optimal. Penatalaksanaan nyeri pascaoperatif yang efektif dapat dicapai dengan mengombinasikan analgesia multimodal serta preemptive analgesia.…”

Section: Pendahuluanunclassified

Perbandingan Pemberian Parecoxib Na 40 mg Intravena Preoperatif dengan Pascaoperatif dalam Penatalaksanaan Nyeri Pascaoperatif pada Operasi Laparotomi Ginekologis

Yuswono¹,

Maskoen²,

Fuadi³

2014

jap

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AbstrakMultimodal analgesia dan preemptive analgesia menjadi terapi yang efektif dalam penatalaksanaan nyeri pascaoperatif. Tujuan penelitian ini adalah untuk menganalisis perbandingan pemberian parecoxib Na 40 mg intravena preoperatif dengan pascaoperatif terhadap nilai NRS. Penelitian ekperimental dengan rancangan analisis komparatif dilaksanakan dari Maret-Juni 2013. Subjek adalah wanita usia 18-60 tahun yang menjalani operasi laparatomi ginekologis dengan anestesi umum di Rumah Sakit Dr. Hasan Sadikin Bandung. Subjek terdiri atas 18 orang pada masing masing kelompok. Parecoxib Na 40 mg diberikan pada dua kelompok perlakuan, yaitu pre atau pascaoperatif. Tramadol 200 mg diberikan pascaoperatif pada semua kelompok dan dilakukan penilaian NRS di ruang pemulihan. Nilai NRS 1 lebih banyak ditemukan pada kelompok I, nilai NRS 3 lebih banyak didapatkan pada kelompok II. Nilai NRS pada kelompok I didapatkan nyeri ringan 15 orang dan nyeri sedang 3 orang. Pada kelompok II didapatkan nyeri ringan 15 orang dan nyeri sedang 3 orang, berdasarkan analisis uji chi-kuadrat tidak terdapat perbedaan nilai NRS kedua kelompok. Tidak didapatkan subjek yang memerlukan analgetik tambahan. Simpulan penelitian ini adalah bahwa tidak terdapat perbedaan antara pemberian parecoxib Na 40 mg preoperatif dan pascaoperatif dalam penatalaksanaan nyeri pascaoperatif. Efek analgetik yang lebih baik didapatkan pada pemberian parecoxib Na preoperatif dengan nilai NRS yang lebih rendah.Kata kunci: Laparatomi ginekologis, numerical rating scale, parecoxib Na, preoperatif, pascaoperatif Comparison of Pre-operative and Post-operative Intravenous 40 mg Parecoxib Na in Gynecologic Laparatomy Surgery Post-Operative Pain Management AbstractMultimodal analgesia regimens and preemptive analgesia will improve post-operative pain relief. The purpose of this study was to compare pre-and post-operative parecoxib 40 mg intravenous to NRS value. This experimental study with comparative analytical method was conducted in women 18 to 60 years old who underwent gynecologic laparatomy at Dr. Hasan Sadikin General Hospital Bandung during the period of March to June 2013. Subjects consisted of 18 women for each pre-operative and post-operative group. Parecoxib 40 mg were given to the two groups, pre-operative (group I) and post-operative (group II), while intravenous tramadol 200 mg was also also given to all groups post-operatively. The NRS was calculated at recovery room. NRS value 1 was more frequent in group I while the NRS value 3 more frequent in group II. NRS values in group I: 15 with mild pain (83.3%), 3 with moderate pain (16.7%). In group II the values were 15 with mild pain (83.3%), 3 with moderate pain (16.7%), which was not significant. In conclusion, there is no difference between pre-operative and post-operative parecoxib sodium 40 mg for post operative pain management. There is a better analgetic effect in the group with pre-operative parecoxib which is apparent from lower NRS.

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A clinical trial demonstrates the analgesic activity of intravenous parecoxib sodium compared with ketorolac or morphine after gynecologic surgery with laparotomy

Cited by 40 publications

References 19 publications

Effects of Intrarenal Administration of the Cox-2 Inhibitor Parecoxib During Porcine Suprarenal Aortic Cross-Clamping

Effects of Intrarenal Administration of the Cox-2 Inhibitor Parecoxib During Porcine Suprarenal Aortic Cross-Clamping

Daily Subcutaneous Parecoxib Injection for Cancer Pain: An Open Label Pilot Study

Perbandingan Pemberian Parecoxib Na 40 mg Intravena Preoperatif dengan Pascaoperatif dalam Penatalaksanaan Nyeri Pascaoperatif pada Operasi Laparotomi Ginekologis

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