A clinical study of peripherally inserted central catheter-related venous thromboembolism in patients with hematological malignancies

Abstract

This study aimed to explore the risk factors of peripherally inserted central catheter (PICC)-related venous thromboembolism (CRT) in patients with hematological malignancies and the predictive ability of the thrombotic risk assessment models (RAMs). The clinical data of the 117 eligible patients with hematological neoplasms at Mianyang Central Hospital with PICC from May 2018 to May 2020 were analyzed in this retrospective study. Thrombosis risk scores were calculated in patients with image-confirmed PICC-related thromboembolism. CRT occurred in 19 cases. Compared to the CRT-free group, the CRT group was older and showed higher body mass index (BMI), leukocyte count level, and the prevalence of diabetes mellitus. Multivariable logistic regression analysis showed that BMI (P = 0.03) was a significant risk factor for CRT. The area under the receiver operating characteristic curve for the Caprini scale (P = 0.01) was higher than that of the modified Wells scale (P = 0.94), the revised Geneva scale (P = 0.83), Padua scale (P = 0.59), and Michigan scale (P = 0.80). The sensitivity and specificity for the Caprini scale, Padua scale, modified Wells scale, the revised Geneva scale, and Michigan risk score were 63.3%/73.7%, 100%/0.00%, 95.9%/5.3%, 31.6%/73.7%, and 1.0%/99.0%, respectively. Caprini RAM had a better predictive ability for CRT in patients with hematological malignancies. Michigan risk score may not be better than Caprini RAM in this population.

Peripherally Inserted Central Venous Catheter for Pediatric Hematologic Diseases; A Retrospective 11-year Single-center Experience.

“…In critically ill children, the reported prevalence of CRT varies from 1-9% [19], and, among different cancer centers, the venous thromboembolism rates, in patients with acute leukemia, range from < 1-81% [17][18][19][20]30]. Jaffray et al found a CRT incidence rate of 9%±1.4%[26], while a higher incidence (16.2%) was observed in 117 adults with hematologic malignancies [31]. The CRT incidence rate was quite similar (2.6%; 0.2/1,000 PICC days) in a monocentris retrospective study, including 612 PICCs/483 adults, treated in our institute [10].…”

The Validation and Modification of the Caprini Risk Assessment Model for Evaluating Venous Thromboembolism after Joint Arthroplasty

“…To assess the risk of thrombosis in patients, various scoring scales have been developed, such as the Caprini scale, Padua scale, modified Wells scale, revised Geneva scale, and Michigan risk score [7][8][9][10][11] . Among these, the Caprini scale is the most commonly used and regarded as the most accurate for many patients 12,13 . Orthopedic surgery patients are at a heightened risk of thrombosis, prompting many specialists to establish guidelines for prevention.…”

“…[7][8][9][10][11] Among these, the Caprini scale is the most commonly used and regarded as the most accurate for many patients. 12,13 Orthopaedic surgery patients are at a heightened risk of thrombosis, prompting many specialists to establish guidelines for prevention. These guidelines typically advise on medication, devices, and other preventative measures to minimize the risk of DVT.…”