A clinical study of histiocytic necrotizing lymphadenitis (Kikuchi's disease) in children

Seo, Ji Hyun; Shim, Hyun Seok; Park, Jung Je; Jeon, Sea Yuong; Kim, Jin Pyeong; Ahn, Sung Ki; Hur, Dong Gu; Ahn, Seong Yong; Kwon, Ohmyoung

doi:10.1016/j.ijporl.2008.07.019

Cited by 30 publications

(42 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Kikuchi disease, also known as Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a rare, benign, self-limiting cause of cervical lymphadenopathy [1,2]. Kikuchi disease has various clinical features with a wide spectrum from absence of systemic symptoms to severe systemic symptoms such as prolonged fever, arthralgia, and hemophagocytic lymphohistiocytosis [2-6].…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic findings of Kikuchi cervical lymphadenopathy in children

2017

View full text Add to dashboard Cite

PurposeThe purpose of this study was to analyze the ultrasonographic (USG) findings of Kikuchi cervical lymphadenopathy in pediatric patients.MethodsBetween April 2007 and September 2016, 84 children (42 male and 42 female; mean±standard deviation age, 12.9±3.2 years; range, 5 to 18 years) confirmed with Kikuchi disease were enrolled. Clinical findings and USG findings of Kikuchi cervical lymphadenopathy were retrospectively reviewed. Localized symptoms, systemic symptoms, and laboratory findings including the white blood cell count, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were analyzed. An analysis of the USG findings included evaluation of the location, size, and presence of intranodal abscess; intranodal calcification; perinodal fat swelling; localized fluid collection; and loss of nodal echogenic hilum.ResultsAmong the patients, 49 (58%) showed localized tenderness at the cervical lymphadenopathy. Fever was present in 55 (66%), while 27 (32%) had prolonged fever. Of 74 with lab results, 54 (73%) had leukopenia but none had leukocytosis. Among the same 74, there was a high ESR (>50 mm/hr) in 10 (14%) and a high CRP level (>5 mg/dL) in seven (9%). The USG findings of most of the patients (n=72, 86%) showed unilateral neck involvement, especially in the left side neck (45 of 72, 63%). The most common site of Kikuchi lymphadenopathy involvement was the area at cervical lymph node level V, at the posterior triangle (n=77, 92%). Conglomerated nodal distribution (n=57, 68%), preserved central nodal echogenic hilum (n=84, 98%), and perinodal fat swelling (n=55, 65%) were common USG findings in the children with Kikuchi. In addition, multiple cervical lymph nodes showed a relatively even size distribution (n=73, 87%).ConclusionThe common USG findings of Kikuchi disease in the pediatric population of our study were multiple conglomerated unilateral cervical lymphadenopathy showing perinodal fat swelling and even size distribution.

show abstract

Section: Introductionmentioning

confidence: 99%

Ultrasonographic findings of Kikuchi cervical lymphadenopathy in children

2017

View full text Add to dashboard Cite

show abstract

“…Night sweats and weight loss, the systemic symptoms frequently seen in lymphoid malignancy, are rare but have been reported. 5,11 Our patient had anorexia and weight loss. Leukopenia can be found in up to 50% of cases.…”

Section: Discussionmentioning

confidence: 79%

“…4 Women are affected more often than male. 5 The onset of K-FD is usually acute or sub-acute. It typically manifests as cervical lymphadenopathy with low grade fever in a previously healthy young individual.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease: A Case Report and Review of literatures

Mollah

Sharmim

Fatmi

2017

Bangladesh J Child Health

View full text Add to dashboard Cite

show abstract

“…Early studies have noted a female predominance, but recent reports have shown only a small female preponderance. However, in the pediatric population, KFD has been found to be more prevalent in boys than in girls (male/female, 1.4e2.8:1) [2,3,8].…”

Section: Discussionmentioning

confidence: 99%

“…KFD in children has different clinical manifestations compared to that in adult populations [2,3]. In the pediatric population, KFD shows completely different gender predominance.…”

Section: Introductionmentioning

confidence: 93%