A clinical report on high‑dose cytarabine therapy for children with acute myeloid leukemia

Wu, Ziliang; Wu, Zelin; Zou, Yawei; Guan, Jing-Ming; Wu, Shangzhi; Chen, Dehui

doi:10.3892/mco.2022.2589

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…All cases were diagnosed as AML according to the 2008 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues ( 20 ). Of note, some cases were included in a trial of HDCT by Wu et al ( 21 ), with an 80% 5-year survival rate. Prior to data collection, written informed consents were obtained from the legal guardians of each participant and approval was obtained from the Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University (Guangzhou, China).…”

Section: Methodsmentioning

confidence: 99%

Quantitative cost‑effectiveness index of cancer treatments

Yang

Chen

2023

Med Int

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In spite of advancements being made in technology and treatment strategies, which have markedly improved the survival rate of patients, the cost of cancer care worldwide has increased over the past decades. The presence of several cost-effectiveness ratios has provided significant indexes to assess the balance between cost and effectiveness. However, the currently available indexes still fail to provide a comprehensive and objective evaluation of cancer treatment. Therefore, the present study developed a novel approach, namely a quantitative cost-effectiveness index of cancer treatment, based on the calculation of the hospitalization expense index and efficacy evaluation index. The present study used the data of 16 patients with childhood acute myeloid leukemia who received the high-dose chemotherapy as an example, and the quantitative cost-effectiveness index was used to evaluate the value of this approach. As the increasing prevalence of cancer and the rising cost of pharmaceuticals have contributed to the expenditure, the development of this index may help to solve the current dilemma of cancer treatment and may prove to be essential for the development of an effective approach which may be accessible to and affordable by common persons; thus would then lead to a higher cure rate.

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Section: Methodsmentioning

confidence: 99%

Quantitative cost‑effectiveness index of cancer treatments

Yang

Chen

2023

Med Int

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“…A biosensor has an input modality that can bind to the analyte and an output modality that can detect it [51] . Optical imaging (fluorescence (FL), two‐photon FL, and Raman imaging), [52] PET/SPECT (positron emission tomography/single‐photon emission computed tomography), [53] MRI (magnetic resonance imaging), [54] PAI (photoacoustic imaging), [55] CT (computed tomography) [56] and multimodal imaging are few currently used molecular imaging techniques using nanoparticles [57] . Each bio‐imaging approach is distinct and has its own set of pros and cons.…”

Section: Carbon‐based Nanomaterials In Cancer Diagnosismentioning

confidence: 99%

Carbon‐Based Nanomaterials for Cancer Treatment and Diagnosis: A Review

Thomas

Baby

Raman³

et al. 2022

ChemistrySelect

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Early detection and treatment is a successful method to fight against cancer. The use of conventional methods often limits the early-stage detection of the same. Nanotechnology, especially nanomedicine, has become an evolving field in research today. Nanoparticles, with their diverse application in medicine, have grown tremendously. Despite their physicochemical properties, the toxicity of nanoparticles in living organisms has helped the scientific community develop these nanoparticles for cancer treatment. In this review, we highlight the two different types of synthesis of nanoparticles: Top-down and Bottom-up approaches, many instances of various techniques and other inorganic nanoparticles that are good platforms for bioimaging and biosensing applications, drug delivery nanocarriers for specific tumor targeting, thereby reducing the toxicity to healthy tissues and Photodynamic therapy (PDT) and Photo Thermal Therapy (PTT), their mechanism and nanoparticles and examples of their surface functionalization used in cancer treatment.

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“…In addition, recent advances in MRI processing methods allow a quantitative evaluation of targeted efficacy in tumors, which can be applied to different T 2 contrast substances [11] . Besides, Fe 3 O 4 NPs have been shown to be safe for cancer patients [12] …”

Section: Introductionmentioning

confidence: 99%

Near‐Infrared Emission‐Cyanine 5.5 and Doxorubicin Loaded Magnetite Nanoparticles for Dual In Vivo Magnetic Resonance and Biodistribution Imaging

Son Phan,

Thuy Doan,

Thu Huong Le

et al. 2023

ChemistrySelect

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The in vivo imaging of the drug distribution during cancer treatment plays an important role in helping physicians and pharmacists to monitor the progress of treatment and improve the effectiveness of therapy. Our goal in this work was to prepare a multifunctional nano drug delivery system that not only co‐loaded iron oxide nanoparticles (Fe3O4 NPs) and Doxorubicin (Dox) but also attached the near‐infrared fluorescent agent Cyanine 5.5 based on poly(lactide)‐tocopheryl polyethylene glycol 1000 succinate (PLA‐TPGS) copolymer. Cyanine 5.5 was attached to the surface Fe3O4 NPs via the NH−CO chemical bond, followed by co‐loading of Dox onto the PLA‐TPGS copolymer by the emulsion solvent evaporation method. The structural, morphological, dimensional, stability, and optical‐magnetic properties of the as‐synthesized nanosystem were fully characterized. From the drug‐released study, the prolonged release of Dox accelerated with increasing acidic conditions (at pH 5.0 and 6.5), while a slow release was observed at pH 7.4. Through the MTT assay, the nanosystem had cellular toxicity against Hep−G2 and HeLa cell lines with low IC50 values of 0.42 and 0.78 μg.mL−1 in terms of Dox concentration, respectively. At a magnetic field of 7 T, this nanosystem also exhibited a high r2/r1 ratio of 164.5 and a strong contrast magnetic resonance (MR) image in the liver. In vivo biodistribution studies revealed that the highest fluorescence intensity achived in the liver after 6 h, and the nanosystem was eliminated from the body after at least 24 h. Collectively, these results demonstrated that the PLA‐TPGS‐Fe3O4‐Cyanine 5.5‐Dox nanosystem is a good candidate for simultaneously increasing contrast for MR and near‐infrared fluorescence imaging.

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A clinical report on high‑dose cytarabine therapy for children with acute myeloid leukemia

Cited by 3 publications

References 26 publications

Quantitative cost‑effectiveness index of cancer treatments

Quantitative cost‑effectiveness index of cancer treatments

Carbon‐Based Nanomaterials for Cancer Treatment and Diagnosis: A Review

Near‐Infrared Emission‐Cyanine 5.5 and Doxorubicin Loaded Magnetite Nanoparticles for Dual In Vivo Magnetic Resonance and Biodistribution Imaging

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