Carbon‐Based Nanomaterials for Cancer Treatment and Diagnosis: A Review

Thomas, Dieney Thresia; Baby, Anjana; Raman, Vidya; Sreeja, P B

doi:10.1002/slct.202202455

Cited by 13 publications

(3 citation statements)

References 151 publications

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“…In this class of nanocarriers, carbon nanotubes (CNTs), graphene and its derivatives, including graphene oxide (GO) and reduced graphene oxide (rGO), and fullerene have gained a greater prominence for cancer nanotherapy in recent years [ 136 ]. These materials have been widely explored as drug nanocarriers and natural compounds applied in treating cancer cells, in photothermal medicine, and as cancer detection and imaging agents [ 137 , 138 ].…”

Section: Application Of Nanotechnology Improving the Efficiency Of Po...mentioning

confidence: 99%

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Vieira,

Tessaro,

Lima

et al. 2023

Nutrients

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Polyphenols derived from fruits, vegetables, and plants are bioactive compounds potentially beneficial to human health. Notably, compounds such as quercetin, curcumin, epigallocatechin-3-gallate (EGCG), and resveratrol have been highlighted as antiproliferative agents for cancer. Due to their low solubility and limited bioavailability, some alternative nanotechnologies have been applied to encapsulate these compounds, aiming to improve their efficacy against cancer. In this comprehensive review, we evaluate the main nanotechnology approaches to improve the therapeutic potential of polyphenols against cancer using in vitro studies and in vivo preclinical models, highlighting recent advancements in the field. It was found that polymeric nanomaterials, lipid-based nanomaterials, inorganic nanomaterials, and carbon-based nanomaterials are the most used classes of nanocarriers for encapsulating polyphenols. These delivery systems exhibit enhanced antitumor activity and pro-apoptotic effects, particularly against breast, lung, prostate, cervical, and colorectal cancer cells, surpassing the performance of free bioactive compounds. Preclinical trials in xenograft animal models have revealed decreased tumor growth after treatment with polyphenol-loaded delivery systems. Moreover, the interaction of polyphenol co-delivery systems and polyphenol–drug delivery systems is a promising approach to increase anticancer activity and decrease chemotherapy side effects. These innovative approaches hold significant implications for the advancement of clinical cancer research.

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Section: Application Of Nanotechnology Improving the Efficiency Of Po...mentioning

confidence: 99%

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Vieira,

Tessaro,

Lima

et al. 2023

Nutrients

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“…For carbon-based nanomaterials, they can serve as photothermal agents for photothermal antibacterial and photothermal tumor ablation due to their broad-spectrum light-absorption properties. [235][236][237][238] However, the disadvantages such as poor solubility and negative material-biological interface interactions limit their further applications. 239,240 To address this issue, MSNscoated carbon-based nanomaterials have been created.…”

Section: Metal Compound Nps/msns Nanocompositesmentioning

confidence: 99%

Multifunctional mesoporous silica nanoparticles for biomedical applications

Xu,

Li,

Shi

et al. 2023

Sig Transduct Target Ther

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Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, and excellent biocompatibility. Over the past two decades, researchers have developed a wide variety of MSNs-based nanoplatforms through careful design and controlled preparation techniques, demonstrating their adaptability to various biomedical application scenarios. With the continuous breakthroughs of MSNs in the fields of biosensing, disease diagnosis and treatment, tissue engineering, etc., MSNs are gradually moving from basic research to clinical trials. In this review, we provide a detailed summary of MSNs in the biomedical field, beginning with a comprehensive overview of their development history. We then discuss the types of MSNs-based nanostructured architectures, as well as the classification of MSNs-based nanocomposites according to the elements existed in various inorganic functional components. Subsequently, we summarize the primary purposes of surface-functionalized modifications of MSNs. In the following, we discuss the biomedical applications of MSNs, and highlight the MSNs-based targeted therapeutic modalities currently developed. Given the importance of clinical translation, we also summarize the progress of MSNs in clinical trials. Finally, we take a perspective on the future direction and remaining challenges of MSNs in the biomedical field.

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“…Carbon-based nanoparticles include carbon nanotubes, graphene, and carbon dots and offer several advantages for CRC diagnosis. Compared with QDs and gold nanoparticles, the biocompatibility of carbon nanoparticles is a notable characteristic that ensures their safe administration in vivo without significant adverse health effects [62]. In addition, these nanoparticles exhibit a large surface area and high electrical conductivity, which makes them ideal for functionalization with specific targeting ligands or biomolecules [63], and they can be integrated with electrical-based sensors such as impedance and electrochemical sensors that are common in point-of-care platforms.…”

Section: Carbon-based Nanoparticlesmentioning

confidence: 99%

Current Status and Emerging Trends in Colorectal Cancer Screening and Diagnostics

Beniwal,

Lamo,

Kaushik

et al. 2023

Biosensors

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Colorectal cancer (CRC) is a prevalent and potentially fatal disease categorized based on its high incidences and mortality rates, which raised the need for effective diagnostic strategies for the early detection and management of CRC. While there are several conventional cancer diagnostics available, they have certain limitations that hinder their effectiveness. Significant research efforts are currently being dedicated to elucidating novel methodologies that aim at comprehending the intricate molecular mechanism that underlies CRC. Recently, microfluidic diagnostics have emerged as a pivotal solution, offering non-invasive approaches to real-time monitoring of disease progression and treatment response. Microfluidic devices enable the integration of multiple sample preparation steps into a single platform, which speeds up processing and improves sensitivity. Such advancements in diagnostic technologies hold immense promise for revolutionizing the field of CRC diagnosis and enabling efficient detection and monitoring strategies. This article elucidates several of the latest developments in microfluidic technology for CRC diagnostics. In addition to the advancements in microfluidic technology for CRC diagnostics, the integration of artificial intelligence (AI) holds great promise for further enhancing diagnostic capabilities. Advancements in microfluidic systems and AI-driven approaches can revolutionize colorectal cancer diagnostics, offering accurate, efficient, and personalized strategies to improve patient outcomes and transform cancer management.

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Carbon‐Based Nanomaterials for Cancer Treatment and Diagnosis: A Review

Cited by 13 publications

References 151 publications

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Recent Progress in Nanotechnology Improving the Therapeutic Potential of Polyphenols for Cancer

Multifunctional mesoporous silica nanoparticles for biomedical applications

Current Status and Emerging Trends in Colorectal Cancer Screening and Diagnostics

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