A clinical, dermoscopic, and histopathological study of Dermatosis Papulosa Nigra (<scp>DPN</scp>) – An Indian perspective

Bhat, Ramesh M; Patrao, Ninon; Monteiro, Rochelle Cheryl; Sukumar, D

doi:10.1111/ijd.13633

Cited by 14 publications

(8 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The histology is similar to that of SKs of the acanthotic or reticular type. The lesions frequently harbor mutations of FGFR3, as do SKs 16, 34, 35 .…”

Section: Pathogenesismentioning

confidence: 99%

Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

View full text Add to dashboard Cite

Seborrheic keratosis (SK) is a common benign epidermal tumor with predominance in adult patients. Whereas common SKs are more frequent in Caucasians, dermatosis papulosa nigra is more prevalent in patients with a Fitzpatrick skin type of at least 3. There seems to be a link between extrinsic skin aging and the occurrence of SK. Mutations of fibroblast growth factor receptor 3 and other signaling molecules are a frequent finding in SK lesions. However, this does not translate into any malignant potential. Viral infections are particularly common in genital lesions, although their pathogenetic relevance for SK is questionable. Different histologic and clinical subtypes have been identified. The great variability of SKs raises some difficulties in diagnosis. Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma. Eruptive SKs can be a paraneoplastic condition known as the Leser–Trélat sign. New targeted cancer treatments can cause a pseudo-Leser–Trélat sign. The treatment in practice is mainly minor surgery, including cryosurgery, shave excisions, and laser-assisted removal. The medical approaches have only limited effects. Recently, two formulations for topical therapy have been evaluated: a product with 40% hydrogen peroxide (HP40) and an aqueous nitric–zinc complex. Based on clinical trials, HP40 seems to be a promising alternative to surgery, in particular for facial lesions.

show abstract

“…The histology is similar to that of SKs of the acanthotic or reticular type. The lesions frequently harbor mutations of FGFR3, as do SKs 16, 34, 35 .…”

Section: Pathogenesismentioning

confidence: 99%

Recent advances in managing and understanding seborrheic keratosis

Wollina

2019

F1000Res

View full text Add to dashboard Cite

show abstract

“…and others of individuals with darker pigmentation range from 10% to 75%. 33 DPN affects women twice as much as men and studies have shown that patients with the condition reported positive family histories in 77%-93% of cases. 34 The cause of DPN is unknown but is considered a variant of seborrheic keratoses, despite it being considered a clinically and histologically distinct entity.…”

Section: Dermatosis Papulosis Nigramentioning

confidence: 99%

Differential diagnosis of melasma and hyperpigmentation

Honigman

Rodrigues

2022

Dermatological Reviews

View full text Add to dashboard Cite

Background: Melasma is a common disorder of acquired hyperpigmentation affecting millions of people worldwide, predominantly women. Despite the incidence, there are numerous hyperpigmentary conditions which may clinically resemble melasma. The differential diagnosis of melasma is therefore wide and may prove to be a diagnostic challenge for clinicians. This can delay the appropriate treatment, adversely impacting sufferers. Our review aims to provide clinicians with an understanding of and a comprehensive approach to assessing, diagnosing and treating melasma and other disorders of hyperpigmentation.

show abstract

“…While a Caucasian predominance has been assumed, SKs occur with near-equivalent incidence in Korean males (Fitzpatrick I-V) as in Caucasians and are generally known to occur in diverse skin types [26]. DPN is found more often in African American, East Asian, and South Asian populations (Fitzpatrick IV-VI) with a consistently reported predominance in women and is thought to be underrecognized [33][34][35][36]. There is a high likelihood of family history, especially in individuals with large numbers of lesions [37][38][39][40][41].…”

Section: Epidemiologymentioning

confidence: 99%

Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses

Sun

Halpern

2021

Dermatology

View full text Add to dashboard Cite

Seborrheic keratoses (SKs) are ubiquitous, generally benign skin tumors that exhibit high clinical variability. While age is a known risk factor, the precise roles of UV exposure and immune abnormalities are currently unclear. The underlying mechanisms of this benign disorder are paradoxically driven by oncogenic mutations and may have profound implications for our understanding of the malignant state. Advances in molecular pathogenesis suggest that inhibition of Akt and APP, as well as existing treatments for skin cancer, may have therapeutic potential in SK. Dermoscopic criteria have also become increasingly important to the accurate detection of SK, and other noninvasive diagnostic methods, such as reflectance confocal microscopy and optical coherence tomography, are rapidly developing. Given their ability to mimic malignant tumors, SK cases are often used to train artificial intelligence-based algorithms in the computerized detection of skin disease. These technologies are becoming increasingly accurate and have the potential to significantly augment clinical practice. Current treatment options for SK cause discomfort and can lead to adverse post-treatment effects, especially in skin of color. In light of the discontinuation of ESKATA in late 2019, promising alternatives, such as nitric-zinc and trichloroacetic acid topicals, should be further developed. There is also a need for larger, head-to-head trials of emerging laser therapies to ensure that future treatment standards address diverse patient needs.

show abstract

A clinical, dermoscopic, and histopathological study of Dermatosis Papulosa Nigra (DPN) – An Indian perspective

Cited by 14 publications

References 7 publications

Recent advances in managing and understanding seborrheic keratosis

Recent advances in managing and understanding seborrheic keratosis

Differential diagnosis of melasma and hyperpigmentation

Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses

Contact Info

Product

Resources

About