Recent advances in managing and understanding seborrheic keratosis

Abstract

Seborrheic keratosis (SK) is a common benign epidermal tumor with predominance in adult patients. Whereas common SKs are more frequent in Caucasians, dermatosis papulosa nigra is more prevalent in patients with a Fitzpatrick skin type of at least 3. There seems to be a link between extrinsic skin aging and the occurrence of SK. Mutations of fibroblast growth factor receptor 3 and other signaling molecules are a frequent finding in SK lesions. However, this does not translate into any malignant potential. Viral infections are particularly common in genital lesions, although their pathogenetic relevance for SK is questionable. Different histologic and clinical subtypes have been identified. The great variability of SKs raises some difficulties in diagnosis. Dermoscopy is the preferred non-invasive diagnostic method, in particular to differentiate pigmented SKs from other pigment tumors, including cutaneous melanoma. Eruptive SKs can be a paraneoplastic condition known as the Leser–Trélat sign. New targeted cancer treatments can cause a pseudo-Leser–Trélat sign. The treatment in practice is mainly minor surgery, including cryosurgery, shave excisions, and laser-assisted removal. The medical approaches have only limited effects. Recently, two formulations for topical therapy have been evaluated: a product with 40% hydrogen peroxide (HP40) and an aqueous nitric–zinc complex. Based on clinical trials, HP40 seems to be a promising alternative to surgery, in particular for facial lesions.

Exogenous interleukin-2 can rescue in-vitro T cell activation and proliferation in patients with a novel capping protein regulator and myosin 1 linker 2 mutation

“…To the best of our knowledge, it has not been described previously in children or adolescents, and is thought to be associated with skin aging. Eruptive seborrheic keratosis might be a paraneoplastic condition, also known as the Leser–Trélat sign [28]. Therefore, P2 underwent a comprehensive work‐up to rule out malignancy with negative results.…”

Multiple seborrheic keratoses in a previously irradiated site

“…Clinically, it is characterized by brownish, well-defined papules with agreasy surface. 4 , 5 Based on clinical suspicion, dermoscopy helps in its diagnosis, which is confirmed by histopathology. 5 …”

“…Radiotherapy has numerous effects on skin tissue, ranging from acute (up to six months after therapy initiation) to chronic; depending on the location, size, and depth of the irradiated tumor, these effects can be classified as mild, moderate, or severe. 2 , 3 , 5 The patient presented chronic symptoms.…”

“…Moreover, radiation damage causes inflammation, cell recruitment, DNA damage, and cytokine generation. 3 , 5 …”

“…Recent studies demonstrated that other oncogenes (TERT and DPH3) are also involved in the genesis of the lesions. 5 …”