Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses

Sun, Mary; Halpern, Allan C.

doi:10.1159/000517070

Cited by 25 publications

(30 citation statements)

References 170 publications

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“…These lesions involve the lower leg (around the ankle) and are more often seen in elderly males. They are clinically characterized by a white to yellow, warty surface 24 . The name Stucco Keratosis is derived from its typical “stuck on” appearance.…”

Section: Pathogenesismentioning

confidence: 99%

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

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Seborrheic keratosis (SK) is a common, benign tumor that can occur on everybody site and can be conservatively managed. Cosmetic concerns, especially when a lesion involves the facial area, are the most common reason for excision. SK shows male gender preponderance and increasing age is an independent association with the condition. Even though more prevalent in the elderly, it has also been reported in younger age groups like adolescents and young adults. Precise pathogenesis is still obscure, but ultra-violet exposure represents a predisposing factor to SK by altering the biochemical concentration and expression of factors like Glutamine deaminases, endothelin, and stem cell factor. Moreover, the accumulation of amyloid-associated protein has also been postulated. Involvement of genitalia has been associated with human papillomavirus infection. Recently, Merkel cell polyomavirus nucleic acid was also detected in SK. Several oncogenic mutations involving FGFR-3 and FOXN1 have been identified. SKs are usually classified clinically and histologically. Dermatoscopy is a noninvasive alternative diagnostic technique widely used in differentiating SK from other benign and malignant tumors. In terms of treatment, topical agents, shave dissection, cryosurgery, electrodesiccation, laser application and curettage under local anesthesia are safe methods for eradication of SKs, mostly for cosmetic purposes. Though generally safe, the latter techniques may occasionally cause postprocedure depigmentation, scarring, and recurrence. Nanosecond-pulsed electric field technology is a promising new technique with fewer side-effects.

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Section: Pathogenesismentioning

confidence: 99%

Update of pathophysiology and treatment options of seborrheic keratosis

Gorai¹,

Ahmad

Raza

et al. 2022

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…In children, SK is easily confused with VP. On RCM, SK-specific characteristics include cerebriform-shaped, abnormal dermal papilla, which have been proven to be very valuable in adult 2,4,8 but not pediatric patients.…”

Section: Discussionmentioning

confidence: 99%

In vivo evaluation of facial papule dermatoses with reflectance confocal microscopy in children

Chen

Wang

Gao

et al. 2022

Skin Research and Technology

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Background Molluscum contagiosum (MC), milia, keratosis pilaris (KP), verruca plana (VP), seborrheic keratosis (SK), and juvenile xanthogranuloma (JXG) are common papule dermatoses on the face of children that have a similar appearance. In vivo evaluation of facial papule dermatoses with reflectance confocal microscopy (RCM) is helpful in the diagnosis of these ambiguous lesions in children. The purpose of this study was to clarify the RCM characteristics of MC, milia, KP, VP, SK, and JXG and explore the clinical application value of RCM for these common facial papule dermatoses. Methods We recruited 113 patients referred for unequivocal facial papule dermatosis, including 21 patients with MC, 17 patients with milia, 19 patients with KP, 36 patients with VP, 8 patients with SK, and 12 patients with JXG. We evaluated the characteristics and distinguishing features of the six kinds of facial papule dermatoses using RCM. Results The main RCM features of the six dermatoses included a well‐demarcated border of the lesion area. MC, milia and KP all manifested cyst‐like structures, and their distinguishing features were the location of the cystic structures and the refractive index of the contents. Although VP, SK, and JXG did not have obvious cystoid structures, VP was typically characterized by uniformly distributed petal‐like structures with a medium‐to‐high refractive index in the epidermis. With regard to SK, the characteristic features were an obviously thickened epidermis and cobblestone‐like structures. JXG was mainly characterized by multiple large round and ovoid cells with a foamy cytoplasm, and discoid‐shaped multinucleated large cells were diffusely distributed in the dermis. Conclusion RCM allows the real‐time visualization of major key diagnostic and distinguishing features of common facial papule dermatoses in children, including MC, milia, KP, VP, SK, and JXG.

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“…4 Upregulation of immune factors such as endothelin-1 (EDN-1) and tumour necrosis factor alpha have also been recently described in the pathogenesis. 1 High levels of tumour necrosis factor alpha causes increased levels of EDN-1 in the lesional skin, which is a strong keratinocyte derived mitogen and enhances melanin production. This may be responsible for pigmentation in SK.…”

Section: Discussionmentioning

confidence: 99%

Seborrheic Keratosis Over Graft Site in a Young Male

NAAZ¹,

ADIL²,

AMIN³

et al. 2022

Turkiye Klinikleri J Dermatol

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Seborrheic keratoses (SK) are common, benign epidermal tumours characterised by proliferation of immature keratinocytes. They usually develop after the age of 50 years with ageing and cumulative UV exposure being the most common predisposing factors. 1 SK can be of various types such as dermatosis papulose nigra, stucco keratosis, melanoacanthoma, irritated SK etc. Stucco keratosis is a type of SK which usually presents over the dorsum of hands and feet and can be characteristically scrapped off. We present a case of multiple stucco SK exclusively at the site of skin graft in a 20 years old male being treated for non-union fracture of both bones of the right leg. CASE REPORTA 20-years-old male was referred from orthopaedics department for complaints of multiple warty lesions over the skin graft site present on the right leg for 2 years. The patient informed that the lesions were asymptomatic and could easily be scraped off. There was no history of itching or crusting. The patient had suffered a road traffic accident 2.5 years back which led to open fracture of both bones of the right leg. He was managed conservatively for 3 months followed by external fixation and the skin defect was covered with a full thickness skin graft taken from left forearm.

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Advances in the Etiology, Detection, and Clinical Management of Seborrheic Keratoses

Cited by 25 publications

References 170 publications

Update of pathophysiology and treatment options of seborrheic keratosis

Update of pathophysiology and treatment options of seborrheic keratosis

In vivo evaluation of facial papule dermatoses with reflectance confocal microscopy in children

Seborrheic Keratosis Over Graft Site in a Young Male

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