A Clear Cell Tumor of the Lung Presenting as a Rapidly Growing Coin Lesion: Is It Really a Benign Tumor?

Kalkanis, Alexandros; Trianti, Myrto; Psathakis, Kostas; Mermigkis, Charalampos; Kalkanis, Dimitrios; Karagkiouzis, Grigorios; Razou, Anna; Tsintiris, Kostas

doi:10.1016/j.athoracsur.2010.07.043

Cited by 12 publications

(15 citation statements)

References 8 publications

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“…Since that time, fewer than 60 cases have been reported in the English literature. CCTL can occur in any age group (range 8 to 73 years), with equal sex prevalence [7,8,10,16,17,23,25,26] or a slight female predominance [4,9,14,24,28]. However, in our study, males were slightly more prone to CCTL than females (29/27).…”

Section: Discussioncontrasting

confidence: 60%

“…The biology of this tumor has traditionally been considered benign, but malignant behavior has been occasionally reported. A 1988 report described a patient with CCTL who died from metastatic CCTL [30], and two other reports described this tumor with rapid growth [5,26]. Our patient was a heavy smoker with a lung mass, which exhibited an intense post-contrast enhancement in the arterial phase and washout in the delay phase on CT scan and was considered to have a malignant potential.…”

Section: Discussionmentioning

confidence: 73%

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Clear cell tumor of the lung: a case report and literature review

et al. 2013

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Clear cell tumor of the lung is a rare and benign pulmonary tumor; only sporadic cases have been reported. Here, we report the case of a 38-year-old man with recurrent cough, blood-streaked sputum and left chest pain. A chest computed tomography scan showed a round, homogeneous pulmonary mass in the left lower lobe, which exhibited intense heterogeneous enhancement in the arterial phase and homogeneous in the delay phase after injecting a contrast agent. The patient underwent a fine-needle aspiration biopsy and was diagnosed as having a benign clear cell tumor of the lung. The clinical presentation and radiographic investigation of this tumor are summarized in this paper to recognize this rare disease. Interestingly, we found some differences with previously reported cases.

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Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 73%

Clear cell tumor of the lung: a case report and literature review

et al. 2013

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“…Only few cases have reported the interval growth of CCTLs. However, previous reports only stated an interval growth without mentioning the exact change in size (9,12) or suggested a maximum volume doubling time estimated from initial normal chest radiograph (13). No previous reports remarked on serial imaging follow up of CCTL.…”

Section: Discussionmentioning

confidence: 92%

Growth pattern change of a benign clear cell ‘sugar’ tumor of the lung: Serial imaging surveillance over seven years

et al. 2018

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Clear cell tumor of the lung is a rare benign mesenchymal tumor and only sporadic cases have been previously reported. The present study reports the case of a 58-year-old man who presented with an incidentally detected solitary pulmonary nodule. Based on comparisons with serial previous chest and spine radiographs, a growth pattern change in the nodule (initial gradual growth over 4.5 years, then recent no growth over 2.5 years) was identified. The nodule was diagnosed as a benign clear cell tumor of the lung (CCTL) following surgical resection. Few studies have previously reported interval growth of CCTLs and the growth pattern of CCTL is not yet well known. To the best of our knowledge, this is the first reported case in which the growth pattern change of CCTL was identified via serial imaging over 7 years of follow-up.

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“…The biology of CCTLs has traditionally been considered benign; however, certain aggressive cases have been reported, occurring almost exclusively in the lung. One report described the death of a patient from metastatic CCTL, while two other reports demonstrated rapid growth behavior of this type of lung cancer . The literature suggests that the presence of clear cells does not appear to affect prognosis .…”

Section: Discussionmentioning

confidence: 99%

“…Radiological features on contrast‐enhanced computed tomography (CT) show intense heterogeneous enhancement in the arterial phase (wash‐in) and washout in the delayed phase, as a probable result of the tumor vascular stroma . Because of its low metastatic potential, CCTL generally has a benign prognosis, although a few malignant clinical cases have been reported . More aggressive behavior has been associated with a larger diameter (> 2.5 cm), abundant mitoses, necrosis, and the presence of uncommon symptoms …”

Section: Introductionmentioning

confidence: 99%

Early clear cell “sugar” lung cancer management: A case report and a brief literature review

Sjniari¹,

Miele

Stati³

et al. 2019

Thoracic Cancer

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A clear cell tumor is a histological entity that rarely originates outside of the kidney. We describe a rare case of a clear cell tumor of the lung, also known as “sugar cancer,” that occurred in a 74 year‐old male patient, and perform a brief literature review. This report highlights the importance of an adequate disease management team, including surgeons, oncologists, and pathologists, to identify the best therapeutic approach to improve survival rates and the quality of life of patients affected by this rare disease.

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A Clear Cell Tumor of the Lung Presenting as a Rapidly Growing Coin Lesion: Is It Really a Benign Tumor?

Cited by 12 publications

References 8 publications

Clear cell tumor of the lung: a case report and literature review

Clear cell tumor of the lung: a case report and literature review

Growth pattern change of a benign clear cell ‘sugar’ tumor of the lung: Serial imaging surveillance over seven years

Early clear cell “sugar” lung cancer management: A case report and a brief literature review

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