Clear cell tumor of the lung: a case report and literature review

Wang, Guangxian; Zhang, Dong; Diao, Xinping; Li, Wen

doi:10.1186/1477-7819-11-247

Cited by 20 publications

(43 citation statements)

References 26 publications

(50 reference statements)

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“…[12] After administration of contrast medium, the key characteristic of CCTL is the intense heterogenous enhancement in the arterial phase and an early washout pattern in delay phases. [8,14] In our report, these 2 patients’ tumors are located in the peripheral portion of pulmonary parenchyma measuring less than 3 cm in diameter. The typical curvilinear or circular patterns of enhancement in the arterial phase are presumably caused by the thin-walled vessels within the tumor.…”

Section: Discussionmentioning

confidence: 67%

“…Patients usually range in age from 8 to 73 years with equal sex prevalence, especially in middle-aged and elder people. [7,8] The biological behavior of this neoplasm is traditionally considered benign; however, malignant CCTL has also been discovered and reported in several other literatures. [9–12] Certain clinicopathologic features such as a diameter >2.5 cm, the presence of symptoms, and extensive necrosis or abundant mitoses visible under an optical microscope are correlated with more aggressive behavior.…”

Section: Discussionmentioning

confidence: 99%

“…[6–8] One recent study indicates that tumors ≥2.2 cm in diameter are more likely to have lobulated appearance and more aggressive symptoms [8] . Its density is generally homogenous without obvious evidence of hemorrhage, necrosis, cavitation, or calcification.…”

Section: Discussionmentioning

confidence: 99%

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Clear cell tumor of the lung

Qian

Lu²,

Li³

et al. 2016

Medicine

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Background:Clear cell tumor of the lung (CCTL) is a rare and mostly benign pulmonary tumor arising from perivascular epithelioid cells. We reported 2 cases of CCTL in a 24-year-old man with chest pain and a 59-year-old man with dyspnea.Methods:Their chest CT images revealed a well-defined, homogeneous nodule located in the peripheral region of lung parenchyma. The solid nodule showed intense heterogenous postcontrast enhancement in the arterial phase and a homogenous appearance in the venous phase. The two patients underwent thoracotomy, and pathological examinations, including immunohistochemical studies revealed that both cases were benign clear cell tumors.Results:Due to the fact that only a few cases about CCTL were reported, clinicopathological aspects and radiological characteristics of this type of tumor are not well established.Conclusion:CCTL is a rare and benign primary tumor and majorly occurs in middle-aged and elder people. The finding of a small vessel extending along and partially wrapping up one side of the mass in the CT-enhanced images might be a helpful feature to differentiate CCTL from other lung neoplasms.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

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Clear cell tumor of the lung

Qian

Lu²,

Li³

et al. 2016

Medicine

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“…Most CCTLs have no symptoms and are usually incidentally discovered on routine chest radiography or CT scan (4). On chest radiographs, CCTLs present as a coin lesion or peripheral solitary nodule with well-defined smooth margins (5,7). Because of the rich vascular stroma, most CCTLs show homogenous intense enhancement on CT scans.…”

Section: Discussionmentioning

confidence: 99%

Growth pattern change of a benign clear cell ‘sugar’ tumor of the lung: Serial imaging surveillance over seven years

et al. 2018

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Clear cell tumor of the lung is a rare benign mesenchymal tumor and only sporadic cases have been previously reported. The present study reports the case of a 58-year-old man who presented with an incidentally detected solitary pulmonary nodule. Based on comparisons with serial previous chest and spine radiographs, a growth pattern change in the nodule (initial gradual growth over 4.5 years, then recent no growth over 2.5 years) was identified. The nodule was diagnosed as a benign clear cell tumor of the lung (CCTL) following surgical resection. Few studies have previously reported interval growth of CCTLs and the growth pattern of CCTL is not yet well known. To the best of our knowledge, this is the first reported case in which the growth pattern change of CCTL was identified via serial imaging over 7 years of follow-up.

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“…Clear cell tumor of the lung (CCTL) is a rare histological subtype of large cell carcinoma according to the World Health Organization (WHO) classification, and is also known as a “sugar tumor” because there is an abundance of glycogen in the cytoplasm . The first case presentation was reported by Liebow and Castleman in 1963, and since then approximately 60 cases have been reported in the literature …”

Section: Introductionmentioning

confidence: 98%

Early clear cell “sugar” lung cancer management: A case report and a brief literature review

Sjniari¹,

Miele

Stati³

et al. 2019

Thoracic Cancer

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A clear cell tumor is a histological entity that rarely originates outside of the kidney. We describe a rare case of a clear cell tumor of the lung, also known as “sugar cancer,” that occurred in a 74 year‐old male patient, and perform a brief literature review. This report highlights the importance of an adequate disease management team, including surgeons, oncologists, and pathologists, to identify the best therapeutic approach to improve survival rates and the quality of life of patients affected by this rare disease.

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Clear cell tumor of the lung: a case report and literature review

Cited by 20 publications

References 26 publications

Clear cell tumor of the lung

Clear cell tumor of the lung

Growth pattern change of a benign clear cell ‘sugar’ tumor of the lung: Serial imaging surveillance over seven years

Early clear cell “sugar” lung cancer management: A case report and a brief literature review

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