A characterization study of resveratrol/sulfobutyl ether-β-cyclodextrin inclusion complex and in vitro anticancer activity

A New Complex of Curcumin with Sulfobutylether-β-Cyclodextrin: Characterization Studies and In Vitro Evaluation of Cytotoxic and Antioxidant Activity on HepG-2 Cells

“…The obtained results concur to assert that complexation of CR with SBE‐β‐CD enhances the drug cytotoxicity, and this effect is likely a consequence of the increase of its solubility. This trend is in agreement with Murali et al, who tested the antiproliferative activity of a CR/β‐CD self‐assembly in a prostate cancer cells line and with Venuti et al, who showed a similar behavior in the case of complexation of resveratrol with SBE‐β‐CD.…”

“…On the basis of this result, we could say that only in the case of the LIO-CX, a real interaction between drug and CD is realized, 10 with a decrease in the crystallinity of the solid structure of CR because of the formation of an inclusion complex with the macrocycle. 27,28 This initial result is fully confirmed by DSC thermograms (Fig. 2b) and SEM photographs (Fig.…”

“…On the contrary, FT‐IR spectra of LIO–CX was essentially similar to that of the pure CD and the sharp peaks belonging to SBE‐β‐CD seemed to predominate and were shifted to higher/lower wave numbers (i.e., 3429–3431 cm −1 ; 1650–1644 cm −1 ). On the basis of this result, we could say that only in the case of the LIO–CX, a real interaction between drug and CD is realized, with a decrease in the crystallinity of the solid structure of CR because of the formation of an inclusion complex with the macrocycle …”

Resveratrol: challenges in analyzing its biological effects

“…Therefore, most plasma Resv and metabolites are bound to proteins or lipids . To enhance Resv levels, much scientific work has been done to increase its solubility through encapsulation or emulsification and through alternative routes of uptake …”

Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery

“…For instance, the change from trans-isomer to cis-isomer can reduce the biological activity of RSV significantly. [27][28][29] Therefore, various new strategies, including encapsulation of RSV into lipid or polymer-based nanoparticles, delivery using carbon nanomaterials and so on, have been developed in an effort to protect the structural integrity of the bioactive molecule. [29][30][31] And these carriers showed high RSV loading capacity, enabling their use in biomedical applications.…”