Resveratrol: challenges in analyzing its biological effects

Vang, Ole

doi:10.1111/nyas.12879

Cited by 21 publications

(17 citation statements)

References 56 publications

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“…7B). Although both ATR and ATM phosphorylate Ser 15 of p53 (60), we found no evidence that resveratrol activated an ATM-Chk2-p53-p21 pathway, a pathway that is generally activated in response to double-stranded DNA breaks. Thus, our data suggest that resveratrol triggers a replication stress-like response rather than classical DNA damage.…”

Section: S C I E N C E S I G N a L I N G | R E S E A R C H A R T I C L Ementioning

confidence: 65%

Resveratrol stimulates the metabolic reprogramming of human CD4 ⁺ T cells to enhance effector function

et al. 2017

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The polyphenol resveratrol activates the deacetylase Sirt1, resulting in various antioxidant, chemoprotectant, neuroprotective, cardioprotective, and anti-inflammatory properties. We found that at high concentrations of resveratrol, human CD4 T cells showed defective antigen receptor signaling and arrest at the G stage of the cell cycle, whereas at low concentrations, cells were readily activated and exhibited enhanced Sirt1 deacetylase activity. Nevertheless, low-dose resveratrol rapidly stimulated genotoxic stress in the T cells, which resulted in engagement of a DNA damage response pathway that depended on the kinase ATR [ataxia telangiectasia-mutated (ATM) and Rad3-related], but not ATM, and subsequently in premitotic cell cycle arrest. The concomitant activation of p53 was coupled to the expression of gene products that regulate cell metabolism, leading to a metabolic reprogramming that was characterized by decreased glycolysis, increased glutamine consumption, and a shift to oxidative phosphorylation. These alterations in the bioenergetic homeostasis of CD4 T cells resulted in enhanced effector function, with both naïve and memory CD4 T cells secreting increased amounts of the inflammatory cytokine interferon-γ. Thus, our data highlight the wide range of metabolic adaptations that CD4 T lymphocytes undergo in response to genomic stress.

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Section: S C I E N C E S I G N a L I N G | R E S E A R C H A R T I C L Ementioning

confidence: 65%

Resveratrol stimulates the metabolic reprogramming of human CD4 ⁺ T cells to enhance effector function

et al. 2017

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“…Numerous preclinical studies have shown that resveratrol inhibits the growth of various cancer cell types in vitro and has convincing cancer preventive effects in various animal models . However, these effects have not yet been confirmed in humans, owing in part to the practical limitations associated with the study of human carcinogenesis in vivo …”

Section: Introductionmentioning

confidence: 99%

Gnetin‐C and other resveratrol oligomers with cancer chemopreventive potential

Espinoza

Inaoka

2017

Annals of the New York Academy of Sciences

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Resveratrol has been extensively studied to investigate its biological effects, including its chemopreventive potential against cancer. Over the past decade, various resveratrol oligomers, both naturally occurring and synthetic, have been described. These resveratrol oligomers result from the polymerization of two or more resveratrol units to form dimers, trimers, tetramers, or even more complex derivatives. Some oligomers appear to have antitumor activities that are similar or superior to monomeric resveratrol. In this review, we discuss resveratrol oligomers with anticancer potential, with emphasis on well-characterized compounds, such as the dimer gnetin-C and other oligomers from Gnetum gnemon, whose safety, pharmacokinetic, and biological activities have been studied in humans.

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“…Resveratrol is a naturally occurring phytochemical that is produced by plants. Resveratrol has been demonstrated to have diverse biological properties, including anti-inflammatory, antioxidant, antiviral, neuroprotective, antifungal and anticancer properties (32,33). Resveratrol has been reported to inhibit cancer cell growth via the AKT signaling pathway (34).…”

Section: Discussionmentioning

confidence: 99%

Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway

Wang

Jin

et al. 2018

Int J Mol Med

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colon cancer is a common type of cancer worldwide and accounts for a significant number of cancer-related deaths. Although surgical techniques and treatment strategies for colon cancer have advanced over the past two decades, the prognosis has not improved considerably. Resveratrol, a natural stilbene compound, possesses antioxidant, cardioprotective and anticancer properties. However, the role of resveratrol in colon cancer has not been fully elucidated. The present study demonstrated that resveratrol inhibited cell proliferation and colony growth in DLD1 and HCT15 colon cancer cells, but did not affect normal colon epithelial cells. The resveratrol-mediated inhibition of cell proliferation correlated with an induction of apoptosis and with G 1 phase cell cycle arrest in colon cancer cells. Additionally, resveratrol treatment decreased the protein expression levels of cyclin D1, cyclin E2 and BCL2 apoptosis regulator, while it increased BCL2 associated X and tumor protein p53, all of which are involved in the regulation of cell cycle and apoptosis. Notably, the results obtained from in silico computational screening identified AKT serine/threonine kinase 1 (AKT1) and AKT2 as novel targets of resveratrol.Computational docking suggested that there are three or four possible hydrogen bonds in the active pocket of AKT1 and AKT2 that contribute to the mode of action of resveratrol. The present study confirmed that resveratrol bound to AKT1 and AKT2 with a pull-down assay. Furthermore, knockdown of AKT1 and AKT2 inhibited cell proliferation and colony growth, by attenuating cell cycle progression and increasing apoptosis in colon cancer cells, effects that were similar to those caused by resveratrol treatment. Taken together, the present results suggest that the targeting effects of resveratrol to AKT1 and AKT2 may be a potent strategy for chemoprevention or therapy for colon cancer.

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Resveratrol: challenges in analyzing its biological effects

Cited by 21 publications

References 56 publications

Resveratrol stimulates the metabolic reprogramming of human CD4 ⁺ T cells to enhance effector function

Resveratrol stimulates the metabolic reprogramming of human CD4 ⁺ T cells to enhance effector function

Gnetin‐C and other resveratrol oligomers with cancer chemopreventive potential

Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway

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Resveratrol: challenges in analyzing its biological effects

Cited by 21 publications

References 56 publications

Resveratrol stimulates the metabolic reprogramming of human CD4 + T cells to enhance effector function

Resveratrol stimulates the metabolic reprogramming of human CD4 + T cells to enhance effector function

Gnetin‐C and other resveratrol oligomers with cancer chemopreventive potential

Resveratrol suppresses colon cancer growth by targeting the AKT/STAT3 signaling pathway

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Product

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Resveratrol stimulates the metabolic reprogramming of human CD4 ⁺ T cells to enhance effector function

Resveratrol stimulates the metabolic reprogramming of human CD4 ⁺ T cells to enhance effector function