A New Complex of Curcumin with Sulfobutylether-β-Cyclodextrin: Characterization Studies and In Vitro Evaluation of Cytotoxic and Antioxidant Activity on HepG-2 Cells

Cutrignelli, Annalisa; Lopedota, Angela; Denora, Nunzio; Iacobazzi, Rosa Maria; Fanizza, Elisabetta; Laquintana, Valentino; Perrone, Mara; Maggi, Vito; Franco, Massimo

doi:10.1002/jps.24200

Cited by 46 publications

(37 citation statements)

References 24 publications

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“…Curcumin is known for its anti-inflammatory and antioxidant properties [35,36] and has been evaluated as a cure in several cancers, based on its low toxicity and high tolerability in patients. However, many patient and animal studies have been unsuccessful in increasing the bioavailability of curcumin; in addition, although curcumin is widely known for its pleiotropic effects and safety, the full therapeutic potential of this compound is not yet understood in many diseases.…”

Section: Resultsmentioning

confidence: 99%

Invertible Micellar Polymer Nanoassemblies Target Bone Tumor Cells But Not Normal Osteoblast Cells

et al. 2015

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Aim:To demonstrate the capability of the invertible micellar polymer nanoassemblies (IMAs) to deliver and release curcumin using the recently discovered mechanism of macromolecular inversion to treat bone tumor cells.Materials & Methods:The effect of IMA-mediated delivery of curcumin on osteosarcoma cell survival was investigated using MTS assays. To assess the effect of IMAs-delivered curcumin on osteosarcoma cell growth, fluorescence-activated cell sorting was performed. The uptake of micellar nanoassemblies was followed using confocal microscopy.Results & Discussion:IMAs-delivered curcumin is effective in blocking osteosarcoma cell growth. It decreases cell viability in human osteosarcoma (MG63, KHOS, and LM7) cells while having no effect on normal human osteoblast cells. It indicates that curcumin-loaded IMAs provide a unique delivery system targeted to osteosarcoma cells.

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Section: Resultsmentioning

confidence: 99%

Invertible Micellar Polymer Nanoassemblies Target Bone Tumor Cells But Not Normal Osteoblast Cells

et al. 2015

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“…Gabaldon et al also used HP-β-CD to increase the aqueous solubility of kaempferol, quercetin, and myricetin and to improve their antioxidant activity due to the protection toward free radical attack [23]. The complexation of curcumin with an ionizable β-CD (SBE-β-CD) enhanced its water solubility and, thus, improved the in vitro cytotoxic (on HepG-2 cells) and antioxidant activity of these compounds [24]. This β-CD derivative and the HP-β-CD are the most used derivatives on the pharmaceutical industry due to their low toxicity and high solubility [16,25,26].…”

Section: Interaction Between Phytochemicals and Cyclodextrinsmentioning

confidence: 99%

Interactions between Bio-Based Compounds and Cyclodextrins

Medronho¹,

Gonçalves²,

RaquelRodríguez-Solana³

et al. 2018

Cyclodextrin - A Versatile Ingredient

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Bio-based compounds, such as "green" surfactants and phytochemicals, are regarded as future sustainable resources for a vast range of applications in a modern society increasingly demanding economical, social, and environmental awareness. Natural compounds from plants (phytochemicals) are very sought by the pharmaceutical, cosmetic, and food industries. On the other hand, the growing interest in "green" surfactants (e.g., carbohydrate-based) is due to, inter alia, their preparation from renewable raw materials, ready biodegradability, and biocompatibility, among other reasons of fundamental, practical, economical, and environmental orders. Despite the wide range of potential applications of these bio-based compounds, their practical use is still limited due to many reasons such as poor aqueous solubility, volatility, reactivity, etc. Generally, when complexed with cyclodextrins, these biobased compounds enhance considerably their performance and potential applications. Thus, this chapter aims at recalling some general fundamental aspects of phytochemicals and "green" surfactants, such as structure, function, and applications. In addition, their interactions with cyclodextrins are discussed from a physicochemical point of view with special focus on the techniques, mathematic modeling, and thermodynamic parameters (e.g., interactions, stoichiometries, association constants, etc.).

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“…CUR microemulsions (CUR-ME) were formed with food-grade chemicals, including soybean lecithin, soybean oil and Tween 80, a Food and Drug Administration-approved surfactant [46]. The effects of low-frequency ultrasound on two oral -HepG-2 -Increased water solubility of CUR -Enhanced anticancer and antitumor activity [138] Hydrogel -HDF -A375…”

Section: Nanoemulsionsmentioning

confidence: 99%

“…The level of telomerase gene expression in cells treated with CUR-CDs was lower than that of cells treated with free CUR [137]. A new complex of CUR with sulfobutyletherb-CDs was proposed by Cutrignelli et al [138]. An in-vitro test on a human hepatic cancer cell lines (HepG-2) showed that complexation positively influences CUR anticancer and antioxidant activity [138].…”

Section: Cur-inclusion Nano-complexmentioning

confidence: 99%

Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art

Ahmad

Alkahtani

Akhter

et al. 2015

Journal of Drug Targeting

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Comprehensive pharmacological screening of curcumin (CUR) has given the evidence that it is an excellent naturally occurring therapeutic moiety for cancer. It is very well tolerated with insignificant toxicity even after high doses of oral administration. Irrespective of its better quality as an anticancer agent, therapeutic application of CUR is hampered by its extremely low-aqueous solubility and poor bioavailability, rapid clearance and low-cellular uptake. A simple means of breaking up the restrictive factor of CUR is to perk-up its aqueous solubility, improve its bioavailability, protect it from degradation, and metabolism and potentiate its targeting capacity towards the cancer cell. The development in the field of nanomedicine has made excellent progresses toward enhancing the bioavailability of lipophilic drugs like CUR. Nanoparticles (NPs) are capable to deliver the CUR at specific area and thereby prevent it from physiological degradation and systemic clearance. In recent year, an assortment of nanomedicine-based novel drug delivery system has been designed to potentiate the bioavailability of CUR towards anticancer therapy. In this review, we discuss the recent development in the field of nanoCUR (NanoCur), including polymeric micelles, liposome, polymeric NPs, nanoemulsion, nanosuspension, solid lipid NPs (SLNPs), polymer conjugates, nanogel, etc. in anticancer application.

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A New Complex of Curcumin with Sulfobutylether-β-Cyclodextrin: Characterization Studies and In Vitro Evaluation of Cytotoxic and Antioxidant Activity on HepG-2 Cells

Cited by 46 publications

References 24 publications

Invertible Micellar Polymer Nanoassemblies Target Bone Tumor Cells But Not Normal Osteoblast Cells

Invertible Micellar Polymer Nanoassemblies Target Bone Tumor Cells But Not Normal Osteoblast Cells

Interactions between Bio-Based Compounds and Cyclodextrins

Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art

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