A chair-side plasma treatment system for rapidly enhancing the surface hydrophilicity of titanium dental implants in clinical operations

Dong, Yuqing; Long, Li; Zhang, Peng; Yu, Deping; Wen, Yana; Zhang, Zheng; Wu, Jie; Chen, Wenchuan

doi:10.2334/josnusd.21-0090

Cited by 5 publications

(19 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Implant surfaces have been previously cleaned with argon plasma to remove contaminants and other impurities (Aronsson et al, 1997). Our previous studies have shown that after treating the titanium implant with this apparatus for 30 s, it significantly reduces the carbon element on the titanium surface (Zheng et al, 2020;Dong et al, 2021). A slight amount of oxygen (0.3%) plasma efficiently kills bacteria (Annunziata et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…SLA implants were treated by a novel NTAP apparatus (CPActive, Chengdu, China) that was manufactured in our lab and has been described in a previous study ( Dong et al, 2021 ). Briefly, the implant was handled with sterile forceps and placed on the collet.…”

Section: Methodsmentioning

confidence: 99%

“…For more convenience in the clinical procedure, a novel NTAP apparatus dedicated to chair-side implant hydrophilic activation was developed ( Dong et al, 2021 ). For this apparatus, dielectric barrier discharge was adopted where argon (3,000 sccm; standard cubic centimeter per minute) and oxygen (0.3%) were used as working gases to activate plasma.…”

Section: Introductionmentioning

confidence: 99%

“…Argon produces high levels of ROS/RNS, and a slight amount of oxygen can increase oxygen-containing groups on the titanium implant surface, which can further enhance the antibacterial properties and hydrophilicity of these biomaterials. Since the water contact angle of the NTAP-functionalized implant was close to 0°, the wetting of the whole implant surface needed only 3 s after contact with water ( Dong et al, 2021 ). Consistent with previous studies, carbon contamination of the NTAP-functionalized implant surface was remarkably reduced and animal experiments have shown the osseointegration this way was faster and stronger compared to that of the traditional SLA titanium implant ( Zheng et al, 2020 ; Dong et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Since the water contact angle of the NTAP-functionalized implant was close to 0°, the wetting of the whole implant surface needed only 3 s after contact with water ( Dong et al, 2021 ). Consistent with previous studies, carbon contamination of the NTAP-functionalized implant surface was remarkably reduced and animal experiments have shown the osseointegration this way was faster and stronger compared to that of the traditional SLA titanium implant ( Zheng et al, 2020 ; Dong et al, 2021 ). Wallkamm et al (2015) have shown that the widely used hydrophilic Straumann SLActive implants had a favorable outcome for at least 3 years in their daily dental practice setup study.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Comparison of early osseointegration of non-thermal atmospheric plasma-functionalized/ SLActive titanium implant surfaces in beagle dogs

Long

Zhang²,

Gan³

et al. 2022

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

Background: Hydrophilic dental implants are gaining increasing interest for their ability to accelerate bone formation. However, commercially available hydrophilic implants, such as SLActive™, have some major limitations due to their time-dependent biological aging and lower cost-effectiveness. The non-thermal atmospheric plasma (NTAP) treatment is a reliable way to gain a hydrophilic surface and enhance osseointegration. However, a few studies have been carried out to compare the osseointegration of NTAP-functionalized titanium implants and commercially available hydrophilic implants.Purpose: In this study, we compare the osseointegration abilities of the NTAP-functionalized titanium implant and Straumann SLActive.Material and methods: The NTAP effectiveness was examined using in vitro cell experiments. Then, six beagle dogs were included in the in vivo experiment. Straumann SLActive implants, SLA implants, and SLA implants treated with NTAP were implanted in the mandibular premolar area of dogs. After 2 w, 4 w, and 8 w, the animals were sacrificed and specimens were collected. Radiographic and histological analyses were used to measure osseointegration.Results: NTAP treatment accelerated the initial attachment and differentiation of MC3T3-E1 cells. In the in vivo experiment, bone parameters (e.g., BIC value and BV/TV) and volume of new bone of NTAP groups were close to those of the SLActive group. Additionally, although there was no statistical difference, the osseointegration of SLActive and NTAP groups was evidently superior to that of the SLA group.Conclusion: NTAP-functionalized implants enhanced cell interaction with material and subsequent bone formation. The osseointegration of the NTAP-functionalized implant was comparable to that of the SLActive implant at the early osseointegration stage.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of early osseointegration of non-thermal atmospheric plasma-functionalized/ SLActive titanium implant surfaces in beagle dogs

Long

Zhang²,

Gan³

et al. 2022

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

show abstract

Novel Nonthermal Atmospheric Plasma Irradiation of Titanium Implants Promotes Osteogenic Effect in Osteoporotic Conditions

Liao,

Xu,

Zheng

et al. 2024

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

Osteoporosis is a metabolic disease characterized by bone density and trabecular bone loss. Bone loss may affect dental implant osseointegration in patients with osteoporosis. To promote implant osseointegration in osteoporotic patients, we further used a nonthermal atmospheric plasma (NTAP) treatment device previously developed by our research group. After the titanium implant (Ti) is placed into the device, the working gas flow and the electrode switches are turned on, and the treatment is completed in 30 s. Previous studies showed that this NTAP device can remove carbon contamination from the implant surface, increase the hydroxyl groups, and improve its wettability to promote osseointegration in normal conditions. In this study, we demonstrated the tremendous osteogenic enhancement effect of NTAP-Ti in osteoporotic conditions in rats for the first time. Compared to Ti, the proliferative potential of osteoporotic bone marrow mesenchymal stem cells on NTAP-Ti increased by 180% at 1 day (P = 0.004), while their osteogenic differentiation increased by 149% at 14 days (P < 0.001). In addition, the results indicated that NTAP-Ti significantly improved osseointegration in osteoporotic rats in vivo. Compared to the Ti, the bone volume fraction (BV/TV) and trabecular number (Tb.N) values of NTAP-Ti in osteoporotic rats, respectively, increased by 18% (P < 0.001) and 25% (P = 0.007) at 6 weeks and the trabecular separation (Tb.Sp) value decreased by 26% (P = 0.02) at 6 weeks. In conclusion, this study proved a novel NTAP irradiation titanium implant that can significantly promote osseointegration in osteoporotic conditions.

show abstract

Bone-to-Implant Contact in Implants with Plasma-Treated Nanostructured Calcium-Incorporated Surface (XPEEDActive) Compared to Non-Plasma-Treated Implants (XPEED): A Human Histologic Study at 4 Weeks

Makary,

Menhall,

Lahoud

et al. 2024

Materials

View full text Add to dashboard Cite

Titanium implants undergo an aging process through surface hydrocarbon deposition, resulting in decreased wettability and bioactivity. Plasma treatment was shown to significantly reduce surface hydrocarbons, thus improving implant hydrophilicity and enhancing the osseointegration process. This study investigates the effect of plasma surface treatment on bone-to-implant contact (BIC) of implants presenting a nanostructured calcium-incorporated surface (XPEED®). Following a Randomized Controlled Trial (RCT) design, patients undergoing implant surgery in the posterior maxilla received additional plasma-treated (n = 7) or -untreated (n = 5) 3.5 × 8 mm implants that were retrieved after a 4-week healing period for histological examination. Histomorphometric analysis showed that plasma-treated implants exhibited a 38.7% BIC rate compared to 22.4% of untreated implants (p = 0.002), indicating enhanced osseointegration potential. Histological images also revealed increased bone formation and active osteoblastic activity around plasma-treated implants when compared to untreated specimens. The findings suggest that plasma treatment improves surface hydrophilicity and biological response, facilitating early bone formation around titanium implants. This study underscores the importance of surface modifications in optimizing implant integration and supports the use of plasma treatment to enhance osseointegration, thereby improving clinical outcomes in implant dentistry and offering benefits for immediate and early loading protocols, particularly in soft bone conditions.

show abstract

A chair-side plasma treatment system for rapidly enhancing the surface hydrophilicity of titanium dental implants in clinical operations

Cited by 5 publications

References 35 publications

Comparison of early osseointegration of non-thermal atmospheric plasma-functionalized/ SLActive titanium implant surfaces in beagle dogs

Comparison of early osseointegration of non-thermal atmospheric plasma-functionalized/ SLActive titanium implant surfaces in beagle dogs

Novel Nonthermal Atmospheric Plasma Irradiation of Titanium Implants Promotes Osteogenic Effect in Osteoporotic Conditions

Bone-to-Implant Contact in Implants with Plasma-Treated Nanostructured Calcium-Incorporated Surface (XPEEDActive) Compared to Non-Plasma-Treated Implants (XPEED): A Human Histologic Study at 4 Weeks

Contact Info

Product

Resources

About