A case of primary squamous cell carcinoma of the liver confirmed at autopsy

Kaneko, Junichi; Matsushita, Masayuki; Nagasawa, Maho; Watanabe, Shinya; Kanayama, Hirokazu; Isono, Tadahiro; Tachibana, Motoi; Teramoto, Yuki; Kobayasi, Yoshimasa

doi:10.2957/kanzo.59.125

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…e most frequently used chemotherapy regimen for hepatic SCC as described in the literature comprises cisplatin and fluorouracil [6]. However, due to its rarity, the definite management of hepatic SCC has not been established thus far.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical course of primary hepatic SCC, especially with underlying liver cirrhosis, is very aggressive, and it is difficult to achieve survival of >6 months even with several therapies combined (including surgical resection, chemotherapy, radiotherapy, and transcatheter arterial chemoembolization) [ 5 ]. The most frequently used chemotherapy regimen for hepatic SCC as described in the literature comprises cisplatin and fluorouracil [ 6 ]. However, due to its rarity, the definite management of hepatic SCC has not been established thus far.…”

Section: Discussionmentioning

confidence: 99%

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Hepatic Squamous Cell Carcinoma Diagnosed by Endoscopic Ultrasound-Guided Fine-Needle Aspiration

Yamada

Shinoura

Kikuchi

2021

Case Reports in Gastrointestinal Medicine

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Primary hepatic squamous cell carcinoma (SCC) is a rare malignancy with aggressive clinical features. This is the first case report of a primary hepatic SCC diagnosed by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), which is a reliable and safe procedure for the histopathological diagnosis of liver lesions, even if the percutaneous approach is difficult due to ascites or hypervascularity at the puncture site. A 52-year-old man presented to the emergency department of a tertiary referral hospital with right upper quadrant abdominal pain and abdominal distention. Given the laboratory data, a diagnosis of spontaneous bacterial peritonitis (SBP) was made. Concurrently, an abdominal computed tomography (CT) scan revealed an 8 cm hypodense mass with delayed peripheral enhancement in the left hepatic lobe and paraaortic and perihepatic lymphadenopathy. As persistent ascites precluded percutaneous liver biopsy, we performed EUS-FNA of the liver mass, and the obtained specimen showed SCC. As otorhinolaryngological consultation and whole-body investigations, including chest CT, upper and lower endoscopy, and positron emission tomography CT, were all unremarkable except for the liver lesion and lymph nodes, a diagnosis of primary hepatic SCC with systemic lymph node metastasis was made. After treatment of SBP with antibiotics, we initiated chemotherapy concurrent with radiation therapy, adapted to his liver function. Radiation and three cycles of chemotherapy were not effective as the disease progressed, as seen on the follow-up CT scan, and the patient died of hepatic failure on the 134th day after diagnosis. In conclusion, EUS-FNA was a reliable method for tissue sampling in liver malignancies, particularly in selected patients with contraindications for percutaneous biopsy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%