laparoscopic ultrasound (LUS) and fluorescence imaging (LFI). Methods: All patients planned to undergo resection of pancreatic or periampullary cancer were included prospectively. Patients received an intravenous infusion of 10 mg indocyanine green (ICG) 1 or 2 days before surgery to allow LFI of potential liver metastases. Suspect lesions were analyzed via biopsy or resection. Results: A total of 21 patients is currently included. Suspect lesions were identified in 3 patients: liver metastases (identified by inspection, LFI and LUS), peritoneal metastases (inspection) and a lesion that appeared to be benign afterwards (LUS). Quality of LFI was good in 8/13 (62%) patients dosed 1 day and in 6/7 (86%) patients dosed 2 days prior to surgery. Eighteen patients had no signs of irresectability during SL; the primary tumor was resected in 16 patients. Two out of 8 patients with a follow-up >6 months after resection developed liver metastases. Conclusion: Despite current preoperative imaging modalities, metastases are still identified during surgery. The current study shows limited added value of LUS and LFI during SL in pancreatic cancer patients. A total of 25 patients will be included and additional follow-up will be available for presentation.
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