A Case of Poisoning From Hair Dye (Paraphenylenediamine)

Close, W. John

doi:10.5694/j.1326-5377.1932.tb42242.x

Cited by 9 publications

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“…Hair dye containing para-toluenediamine and closely related compounds, has been linked to gastrointestinal and neurological toxicity (Close, 1932), mutagenicity (Ames et al, 1975;Searle et al, 1975) and macrocytic anaemia (Baldridge, 1935;Bomford & Rhoads, 1941), as well as several case reports of aplastic anaemia (Baldridge, 1935; Thompson, 1965;Hamilton & Sheridan, 1976;Toghill & Wilcox, 1976). In this report we describe two further cases of probable hair dye induced severe aplastic anaemia.…”

Section: Introductionmentioning

confidence: 65%

Severe aplastic anaemia following the use of hair dye: report of two cases and review of literature

Hopkins

Manoharan

1985

Postgraduate Medical Journal

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Summary:We describe two female patients aged 31 and 62 y who developed severe aplastic anaemia following the use of hair dye containing para-toluenediamine. One received a bone marrow transplant but died after developing graft versus host disease and severe opportunistic infection. The second responded to treatment with methylprednisolone, oxymetholone and antithymocyte globulin and 3 y later she has a normal blood count apart from mild thrombocytopenia.In this paper we also review previously described case reports of aplastic anaemia apparently associated with the use of hair dye.

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