A case of oral squamous cell carcinoma in a nontobacco habitué

Carvalho, Karla; Sawant, Poonam Ramnath; Dhupar, Anita; Spadigam, Anita

doi:10.4103/ijabmr.ijabmr_417_16

Cited by 6 publications

(6 citation statements)

References 8 publications

(13 reference statements)

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“…While some writers claim that non-habit-related OSCC frequently affects young people, others claim that the age of susceptibility is bimodal globally, i.e., between 40 and 70. However, this situation deviates from the bimodal age predilection [11]. The earlier age at which non-habit-associated OSCC develops is thought to be influenced by genetic predisposition, viral etiology, phagocytic diseases, Fanconi anemia (FA), and environmental toxins [11].…”

Section: Agementioning

confidence: 99%

Non-Habit-Related Oral Squamous Cell Carcinoma: A Review

Lalremtluangi,

Dangore-Khasbage

2024

Cureus

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Oral squamous cell carcinoma (OSCC) is a serious and potentially life-threatening condition that can have a profound impact on an individual's health and well-being. Its etiology is commonly known to be habit induced, such as tobacco consumption, smoking, or alcohol abuse. Apart from these etiologies, certain factors that lead to OSCC are also present but are less frequently encountered in hospitals and clinics. However, these non-habitual factors, with their pathogenesis, can lead to OSCC, which may be confusing to certain medical practitioners. This article discusses the various non-habitual causes that can lead to OSCC, as well as their pathophysiology, molecular expression, and related indicators and prognostic factors.

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Section: Agementioning

confidence: 99%

Non-Habit-Related Oral Squamous Cell Carcinoma: A Review

Lalremtluangi,

Dangore-Khasbage

2024

Cureus

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“…[2][3][4] Genes play a crucial role in developing oral squamous cell carcinoma, especially in the tongue and the buccal mucosa. [5] These can predict oral cancer and assist in early diagnosis, especially in precancerous lesions and conditions. [6] The cancer cells undergo modifications and exhibit abnormal metastases, causing a rapid spread.…”

Section: Introductionmentioning

confidence: 99%

Genomics in oral cancer

Muralidharan¹,

Patankar²,

Shah³

et al. 2022

ijhs

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Background: The genetic factors play an essential role in the cell behavior and function in areas affected with cancer, identifying them could help faster risk detection and mitigation of cases that can be easily saved without much therapeutic intervention at the primary stage itself. This review aims to develop comprehensive evidence regarding genomics in oral cancer initiation, regulation, and progress/inhibition. Material and Methods: A systematic review was carried out of all the reported literature on genomics and proteomics as biomarkers from January 2015 to December 2021 across 3 different search engines- Medline/PubMed, Google Scholar and Scopus. There were 61 articles for the genetic components of oral cancer after following the PRISMA guidelines. Results: Among the 61 articles a number of genes were identified which showed either over or under expression in presence of cancer. All of the proteins showed a rise in their levels in cancer cases compared to healthy cohorts and premalignant cases. The levels of these proteins were also raised significantly in the premalignant cases compared to the healthy patients. Conclusion: A conclusion can be drawn that not all gene markers are raised; some show low expressions.

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“…Oral squamous cell carcinoma (OSCC) is the 8 th most common cancer in the world [1]. It accounts for 2-4% of all the cancers in the world and 10% of all cancers in Pakistan [2].…”

Section: Introductionmentioning

confidence: 99%

Discrepancy Between cTNM and pTNM in Patients with Oral Squamous Cell Carcinoma

Tariq¹,

Qureshi²,

Khalid³

et al. 2021

IJCOMS

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Objective: To analyze discrepancy between cTNM and pTNM in patients with squamous cell carcinoma of oral cavity. Study design: Cross-sectional study. Setting & Duration: Cases of OSCC treated in Oral and Maxillofacial Surgery Department, Allied Hospital Faisalabad from December 2017 to November 2020 were included in the study. Methodology: Total 80 patients with biopsy proven OSCC were enrolled in the study. cTNM staging was based on clinical examination and CT/MRI. Primary tumor excision along with neck dissection was done in all patients. Postoperatively pTNM staging was done and compared to cTNM. The clinical, radiological and histopathological lymph node status of patients were compared. Results: Among 80 patients, male to female ratio was 1.6:1. The mean of age was 50.2±10.2 years. The most common site in our center was the lateral border of the tongue. The total coincidence rate between clinical T-stage and pathological T-stage was 57.5%.On comparison between the clinical and pathological N-stage the total coincidence rate was 40%. The total coincidence rate between cTNM and pTNM was 35% and the p-value was insignificant (p>0.05). The sensitivity of CT/MRI for N-stage was 53.3% and specificity was 60% and positive predictive value (PPV) was 53.3% and negative predictive value (NPV) was 60%. Conclusion: Disparity between cTNM and pTNM of OSCC exits that could affect the treatment planning and prognosis.

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A case of oral squamous cell carcinoma in a nontobacco habitué

Cited by 6 publications

References 8 publications

Non-Habit-Related Oral Squamous Cell Carcinoma: A Review

Non-Habit-Related Oral Squamous Cell Carcinoma: A Review

Genomics in oral cancer

Discrepancy Between cTNM and pTNM in Patients with Oral Squamous Cell Carcinoma

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