A Case of Mucoepidermoid Carcinoma of the Parotid Gland Developing in a Child After the Treatment of Acute Lymphoblastic Leukemia

Atahan, I. Lale; Ayhan, Ayşe; Özyar, Enis; Ertoy, Dilek; Gurkaynak, M.

doi:10.3109/08880019509029592

Cited by 12 publications

(7 citation statements)

References 8 publications

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“…Most reported patients were alive and free of disease after treatment of MEC regardless of histological grade [1,[3][4][5][6][7][8][9]. This reinforces the importance of timely and correct diagnosis of this malignant neoplasm so that early surgical treatment can be instituted.…”

Section: Discussionsupporting

confidence: 63%

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Mucoepidermoid carcinoma of parotid as a second malignancy in acute lymphoblastic leukemia

et al. 2015

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Section: Discussionsupporting

confidence: 63%

“…Eight out of these 19 cases, had received MDC along with cranial irradiation, and most had received a dose of 18Gy [1,3,6,9,10]. Total Body Irradiation was also given in another three cases along with MDC [5,9]. Six cases had received multi-drug chemotherapy without any radiotherapy [4,7,9,].…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid carcinoma of parotid as a second malignancy in acute lymphoblastic leukemia

et al. 2015

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“…The development of secondary salivary gland neoplasms has been linked to prior radiation therapy 8. Isolated cases of parotid MEC have been reported in childhood leukemia survivors (Table I) 8,13–18. Of the cases reviewed, all but two patients had received radiation therapy, either cranial or total body.…”

Section: Discussionmentioning

confidence: 99%

Mucoepidermoid carcinoma of the parotid gland as a second malignant neoplasm

Savelli

Klopfenstein

Termuhlen

2004

Pediatric Blood & Cancer

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We report two second malignant neoplasms (SMNs) of the parotid gland. Patient 1 was initially diagnosed with precursor B-cell lymphoblastic lymphoma of the scalp. Eight years after her initial diagnosis she presented with a small, painless mass in the region of her parotid gland. Patient 2 was diagnosed with pre-B-cell acute lymphoblastic leukemia (ALL). Thirteen years after her initial diagnosis she presented with a painless mass in her right cheek. Both patients underwent superficial parotidectomies following excisional biopsies. Pathology revealed low-grade mucoepidermoid carcinoma (MEC) in both cases. Both patients are currently tumor free.

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“…The development of a malignant SGT in patients with a previous malignancy is a rare event, and few cases have been described in the literature. The previous cases reported in the literature are detailed in Table 2 [1, 19, 21, 43-61]. In particular, the mean age of the patients at the time of the first malignancy is 5.5 years, ranging from 1 month to 15 years.…”

Section: Discussionmentioning

confidence: 99%

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

et al. 2020

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Background: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour in paediatric population, accounting for 16% of all cases. Patients affected by a previous solid or leukaemic neoplasm during their childhood may develop a second different tumour during the follow-up. In this setting, salivary gland MEC is relatively frequent, accounting for 6% of the second neoplasms in paediatric patients. Consequently, the occurrence of salivary gland nodules in paediatric patients with a previous neoplasm should be considered an event with a high risk of malignancy that poses peculiar diagnostic challenges. Summary: This study was designed to define clinical and instrumental findings and morphological features of MEC on fine-needle aspiration cytology (FNAC) samples in paediatric patients with and without a previous neoplasm. Five patients under 19 years are included in this series. FNAC was performed in all patients on a parotid nodule. We have identified 2 groups of patients: (a) 2 cases with previous history of malignancy (acute lymphoblastic leukaemia and Hodgkin lymphoma) and (b) 3 cases without previous malignant neoplasms. In all cases, a final diagnosis of MEC was rendered. Key Messages: MEC may occur as a second malignancy in paediatric patients. FNAC is certainly a valid and accurate diagnostic tool for this type of neoplasm, even in the paediatric age, allowing the correct management of the patients.

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A Case of Mucoepidermoid Carcinoma of the Parotid Gland Developing in a Child After the Treatment of Acute Lymphoblastic Leukemia

Cited by 12 publications

References 8 publications

Mucoepidermoid carcinoma of parotid as a second malignancy in acute lymphoblastic leukemia

Mucoepidermoid carcinoma of parotid as a second malignancy in acute lymphoblastic leukemia

Mucoepidermoid carcinoma of the parotid gland as a second malignant neoplasm

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

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