Mucoepidermoid carcinoma of parotid as a second malignancy in acute lymphoblastic leukemia

Tikku, Gargi; Jain, Dhruv; Kumari, Archana; Grover, Rajesh K.

doi:10.1007/s13312-015-0757-0

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…As SMN, it has been previously described in patients treated for ALL and rarely in children treated for AML. [9,25,26] Few reports have been published regarding SMNs in patients treated for glioblastoma. [27,28] We describe here a rare case of an 8-year male child who presented with renal cell carcinoma 6 years after his treatment for glioblastoma.…”

Section: Discussionmentioning

confidence: 99%

Second malignant neoplasms in children and adolescents treated for blood malignancies and solid tumors: A single-center experience of 15 years

Katzilakis

Tsirigotaki

Stratigaki

et al. 2018

Indian J Med Paediatr Oncol

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Context: The occurrence of second malignancies is not rare in children treated for primary tumors. Objectives: The aim of this study was to investigate the occurrence and the outcomes of second malignancies in children and adolescents from a large tertiary pediatric hematology-oncology center. Materials and Methods: A retrospective study was performed looking into the characteristics and outcomes of second malignant neoplasms in children and adolescents treated for primary malignancies in a single center over a 15-year period. Results: Among 270 children and adolescents treated for hematological malignancies and solid tumors from 2000 to 2015, five cases of second malignancy were diagnosed including cancer of the parotid gland, renal cell carcinoma, Hodgkin’s lymphoma, thyroid carcinoma, and transitional liver cell carcinoma in patients previously treated for acute myeloid leukemia, glioblastoma multiforme, B-acute lymphoblastic leukemia, Langerhans cell histiocytosis, and medulloblastoma, respectively. Primary malignancies were treated with chemotherapy in all cases and four out of five patients had also received radiotherapy. Mean age at diagnosis of second malignancy was 10 years and 4 months. Overall survival after diagnosis of second malignancy was 80% at 12 months and 75% at 5 years. Conclusions: Close surveillance and long-term follow-up are mandatory for the identification of late effects in children treated for malignancy.

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Section: Discussionmentioning

confidence: 99%

Second malignant neoplasms in children and adolescents treated for blood malignancies and solid tumors: A single-center experience of 15 years

Katzilakis

Tsirigotaki

Stratigaki

et al. 2018

Indian J Med Paediatr Oncol

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Rearrangement of KMT2A Characterizes a Subset of Pediatric Parotid Mucoepidermoid Carcinomas Arising Metachronous to Acute Lymphoblastic Leukemia

Othman,

Steiner,

Leivo

et al. 2023

Fetal and Pediatric Pathology

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Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

et al. 2020

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Background: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumour in paediatric population, accounting for 16% of all cases. Patients affected by a previous solid or leukaemic neoplasm during their childhood may develop a second different tumour during the follow-up. In this setting, salivary gland MEC is relatively frequent, accounting for 6% of the second neoplasms in paediatric patients. Consequently, the occurrence of salivary gland nodules in paediatric patients with a previous neoplasm should be considered an event with a high risk of malignancy that poses peculiar diagnostic challenges. Summary: This study was designed to define clinical and instrumental findings and morphological features of MEC on fine-needle aspiration cytology (FNAC) samples in paediatric patients with and without a previous neoplasm. Five patients under 19 years are included in this series. FNAC was performed in all patients on a parotid nodule. We have identified 2 groups of patients: (a) 2 cases with previous history of malignancy (acute lymphoblastic leukaemia and Hodgkin lymphoma) and (b) 3 cases without previous malignant neoplasms. In all cases, a final diagnosis of MEC was rendered. Key Messages: MEC may occur as a second malignancy in paediatric patients. FNAC is certainly a valid and accurate diagnostic tool for this type of neoplasm, even in the paediatric age, allowing the correct management of the patients.

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Mucoepidermoid carcinoma of parotid as a second malignancy in acute lymphoblastic leukemia

Abstract: Mucoepidermoid carcinoma should be a differential in any parotid swelling of treated case of pediatric ALL.

Cited by 3 publications

References 10 publications

Second malignant neoplasms in children and adolescents treated for blood malignancies and solid tumors: A single-center experience of 15 years

Second malignant neoplasms in children and adolescents treated for blood malignancies and solid tumors: A single-center experience of 15 years

Rearrangement of KMT2A Characterizes a Subset of Pediatric Parotid Mucoepidermoid Carcinomas Arising Metachronous to Acute Lymphoblastic Leukemia

Fine-Needle Aspiration Cytology Is an Effective Diagnostic Tool in Paediatric Patients with Mucoepidermoid Carcinoma as Secondary Neoplasm

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