A Case of Lichen Planus-Lupus Erythematosus Overlap Syndrome with Eyelid Involvement

Abstract

This is a rare example of two coexisting autoimmune disease entities: lichen planus of the oral mucosa, lip, eyelid and discoid lupus erythematosus of the skin. To our knowledge, this is the first reported case of lichen planus-lupus erythematosus overlap syndrome with eyelid involvement.

Cutaneous lupus erythematosus/lichen planus overlap syndrome

“… 9 , 10 , 11 , 12 In total, 38 cases of CLE/LP overlap syndrome were identified. 1 , 2 , 3 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 Of these 38 cases, 12 were classified as “classic,” 21 were classified as “possible,” and 5 had incomplete workup and thus were unable to be classified as CLE/LP overlap syndrome according to our criterion. Demographic information, clinical features, histologic features, immunofluorescence, serologic findings, laboratory findings, treatments, and treatment responses in these cases are summarized in Table II .…”

“… Topical fluocinonide ointment → improvement. Classic overlap Tursen et al 17 34 yo; F Violaceous, thickened, scaly lesions on scalp, arms, malar, and auricular regions. Buccal and lip mucosa showed white papules with a reticular pattern.…”

Seven-year itch: a perplexing case of lichen planus-lupus erythematosus overlap syndrome

“…Thirty-one patients were presented in these case reports. The clinical presentation and antibody findings of each of these patients are summarized in Table 1 [1,5,[7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Lupus erythematosus-lichen planus overlap syndrome in an HIV-infected individual

“…This LE-LP overlap syndrome has a chronic course with a variable response to treatment. The medications effective in this syndrome are potent topical and systemic steroids, oral retinoids, 8 ciclosporin, 9 hydroxychloroquine 10 and topical tacrolimus 0.1% ointment.…”