Seven-year itch: a perplexing case of lichen planus-lupus erythematosus overlap syndrome

Schmitz, Sarah; Vatanchi, Marjon; Alapati, Usha

doi:10.5070/d3249041418

Cited by 10 publications

(8 citation statements)

References 9 publications

(9 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…По данным литературы, оценка эффективности и безопасности системной и топической терапии перекрестного синдрома производилась на основании отдельных клинических наблюдений, проведение полноценных рандомизированных контролируемых исследований не представляется возможным [11]. К системным препаратам, способным оказывать положительное влияние на течение кожного процесса, стоит отнести системные ретиноиды, антималярийные препараты, системные глюкокортикостероиды, повысить эффективность лечения может дополнительное использование топической противовоспалительной терапии [8][9][10][11]. С учетом возможных побочных эффектов топических ГКС топический ингибитор кальциневрина может стать предпочтительным препаратом для использования на коже лица, интертригинозных зон, при необходимости длительного применения в поддерживающем режиме.…”

Section: Discussionunclassified

“…Трудности диагностики overlapсиндрома заключаются в неспецифичности клинической и патоморфологической картины, необходимости тщательного иммунологического обследования, не всегда доступного в условиях рутинного амбулаторного прие ма. Единых рекомендаций по диагностике и лечению перекрестного синдрома не разработано, по данным отдельных клинических наблюдений, для лечения перекрестного синдрома могут быть использованы системные ретиноиды, антималярийные препараты, системные глюкокортикостероиды в сочетании с топической противовоспалительной терапией [8][9][10]. Обнаружение клинических и иммунологических признаков системной красной волчанки требует наблюдения ревматолога.…”

Section: заключениеunclassified

See 1 more Smart Citation

Lichen planus-lupus erythematosus overlap syndrome

Nikolaeva

Monakhov

Sokolovskiy

2022

Vestnik dermatologii i venerologii

View full text Add to dashboard Cite

The combination of lichen planus and lupus erythematosus is a rarity: no more than fifty cases of overlap syndrome have been described in the world. The clinical picture of overlap syndrome is variable: patients have discoid foci of lupus erythematosus and typical flat polygonal papules of lichen planus, as well as combined manifestations in the form of lid-red plaques with central atrophy and superficial desquamation. Positive antinuclear factor is found in laboratory examination. The histopathological picture is characterized by a combination of histological signs of lichen planus and lupus erythematosus. In some cases, clinical and immunological signs of systemic lupus erythematosus are found in patients with overlap syndrome. We describe two cases of lichen planus and systemic lupus erythematosus.

show abstract

Section: Discussionunclassified

Section: заключениеunclassified

Lichen planus-lupus erythematosus overlap syndrome

Nikolaeva

Monakhov

Sokolovskiy

2022

Vestnik dermatologii i venerologii

View full text Add to dashboard Cite

show abstract

“…Overlap syndrome is characterized by a mixture of clinical and histopathological features of LE and LP. Direct immunofluorescence shows subepidermal spherical deposits of IgM or IgG or granular deposition of immunoglobulin and complement along the dermal-epidermal junction (lupus zone test) ( 6 ). To the best of our knowledge, this is the first reported case of BLP/SLE.…”

Section: Discussionmentioning

confidence: 99%

Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome

Liu

Liang

et al. 2021

Front. Med.

View full text Add to dashboard Cite

Introduction: Lichen planus/lupus erythematosus overlap syndrome is rarely seen in the clinic and has the characteristic clinical manifestations, histopathology, and immunopathology of lichen planus (LP) and lupus erythematosus (LE). This is the first reported case of bullous lichen planus (BLP)/systemic lupus erythematosus (SLE) overlap syndrome with hair loss as the first symptom.Case Presentation: A 48-year-old female presented with alopecia for half a year, and skin lesions accompanied by itching on her face, trunk, and limbs for 3 months. She had a history suggestive of photosensitivity. Laboratory tests and histopathology were performed for diagnosis. Histopathologic features of the upper arm and back of the hand were consistent with BLP, whereas the scalp lesion indicated LE. Laboratory examination indicated positive for antinuclear antibody (ANA) (1:160), leukopenia, increased urinary protein, decreased C3/C4, and normal BP180. The patient was given glucocorticoid combined with acitretin and immunosuppressive therapy after a definite diagnosis of BLP/SLE overlap syndrome. The lesions of the patient disappeared and some hair had regrown during the two years of follow-up.Conclusion: This is the first reported case of BLP/SLE overlap syndrome which responded well to glucocorticoids, retinoids, and immunosuppressive drugs. Multiple biopsies from characteristic lesions will guide doctors to avoid misdiagnoses and delayed treatment.

show abstract

“…There are also reports of mucosal involvement, nail dystrophy and cicatricial alopecia, as well as cases triggered by drugs. 2 , 33 , 34 …”

Section: Clinical Presentation and Differential Diagnosismentioning

confidence: 99%

Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects

Vale¹,

Garcia²

2023

Anais Brasileiros de Dermatologia

View full text Add to dashboard Cite

Seven-year itch: a perplexing case of lichen planus-lupus erythematosus overlap syndrome

Cited by 10 publications

References 9 publications

Lichen planus-lupus erythematosus overlap syndrome

Lichen planus-lupus erythematosus overlap syndrome

Case Report: The First Reported Case of Bullous Lichen Planus-Systemic Lupus Erythematosus Overlap Syndrome

Cutaneous lupus erythematosus: a review of etiopathogenic, clinical, diagnostic and therapeutic aspects

Contact Info

Product

Resources

About