Cutaneous lupus erythematosus/lichen planus overlap syndrome

Jicha, Katherine I.; Wang, David M.; Miedema, Jayson; Díaz, Luis A.

doi:10.1016/j.jdcr.2021.09.031

Cited by 7 publications

(10 citation statements)

References 23 publications

(54 reference statements)

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“…Так, V. Mahler и соавт. в 1998 г. предложили балльный алгоритм диагностики overlap-синдрома, а K. I. Jicha и соавт., основываясь на совокупности клинических, гистологических и иммунологических данных, в 2021 г. выделили «классический» и «вероятный» варианты перекрестного синдрома [5,11].…”

Section: Discussionunclassified

“…: положительный результат АНФ, обнаружение антител к экстрагируемому ядерному антигену, антител к двуспиральной ДНК, антифосфолипидных антител позволяют подтвердить «классический» вариант перекрестного синдрома. Согласно балльному алгоритму V. Mahler и соавт., важным диагностическим критерием является результат ПИФ биоптата пораженной кожи [5,11].…”

Section: Discussionunclassified

“…По данным литературы, оценка эффективности и безопасности системной и топической терапии перекрестного синдрома производилась на основании отдельных клинических наблюдений, проведение полноценных рандомизированных контролируемых исследований не представляется возможным [11]. К системным препаратам, способным оказывать положительное влияние на течение кожного процесса, стоит отнести системные ретиноиды, антималярийные препараты, системные глюкокортикостероиды, повысить эффективность лечения может дополнительное использование топической противовоспалительной терапии [8][9][10][11]. С учетом возможных побочных эффектов топических ГКС топический ингибитор кальциневрина может стать предпочтительным препаратом для использования на коже лица, интертригинозных зон, при необходимости длительного применения в поддерживающем режиме.…”

Section: Discussionunclassified

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Lichen planus-lupus erythematosus overlap syndrome

Nikolaeva

Monakhov

Sokolovskiy

2022

Vestnik dermatologii i venerologii

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The combination of lichen planus and lupus erythematosus is a rarity: no more than fifty cases of overlap syndrome have been described in the world. The clinical picture of overlap syndrome is variable: patients have discoid foci of lupus erythematosus and typical flat polygonal papules of lichen planus, as well as combined manifestations in the form of lid-red plaques with central atrophy and superficial desquamation. Positive antinuclear factor is found in laboratory examination. The histopathological picture is characterized by a combination of histological signs of lichen planus and lupus erythematosus. In some cases, clinical and immunological signs of systemic lupus erythematosus are found in patients with overlap syndrome. We describe two cases of lichen planus and systemic lupus erythematosus.

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Section: Discussionunclassified

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Lichen planus-lupus erythematosus overlap syndrome

Nikolaeva

Monakhov

Sokolovskiy

2022

Vestnik dermatologii i venerologii

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“…Это привело к появлению противоречивых сообщений в литературе, причем в большинстве из них описаны случаи с сосуществующими или перекрывающимися клиническими и гистологическими признаками ДКВ и красного плоского лишая. Согласно имеющимся данным, существуют классический перекрестный синдром (ДКВ/красный плоский лишай) с типичными клинико-гистологическими проявлениями дерматозов и любым положительным серологическим тестом (АНА с титрами ≥1:80 на клетках Hеp2, ENA, анти-дсДНК, анти-Sm, анти-Ro/SS-A, анти-La/SS-B, анти-U1-РНП, антифосфолипидные антитела) и вероятный перекрестный синдром (ДКВ/красный плоский лишай) с типичными клинико-гистологическими проявлениями дерматозов, но с отрицательными иммунологическими показателями, что требует дальнейшего серийного тестирования и наблюдения [43].…”

Section: перекрестный синдром (дкв/красный плоский лишай)unclassified

Skin lesions in systemic lupus erythematosus. Part 2: clinical and histological features

Shumilova¹,

Travkina²,

Reshetnyak³

2022

Sovremennaâ revmatologiâ

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Skin lesions in systemic lupus erythematosus (SLE) are not just a cosmetic defect, accompanied by a deterioration in the quality of life and psychological discomfort, but, possibly, the first sign of a systemic course of disease. Systemic involvement can develop in patients with almost any type of cutaneous lupus erythematosus (CLE), requiring the study of CLE in combination with SLE. Dermatologists are the first to face with skin manifestations of SLE, while other organs and systems affection leads the patient to a rheumatologist. It is important to understand that skin lesions do not cause irreversible organ damage, but continuity of therapeutic approaches between a dermatologist and a rheumatologist is necessary. The review presents the clinical signs, diagnostic features and histological characteristics of CLE.

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“…Inalöz et al reported that hypergranulosis, irregular acanthosis, saw tooth appearance of rete pegs, hydropic degeneration of basal cells with clefts (Max-Joseph spaces), formation of colloid body and band-like dermal lymphocytes occurred more frequently in LP, while basement membrane thickening, hydropic degeneration of basal cells without clefts, and perifollicular and perivascular infiltration were greater in DLE (9). In LP-LE overlap syndrome, Inalöz et al, Schmitz et al, and Jicha et al reported various lesions in a patient that were consistent with LP or DLE (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of histopathological diagnostic criteria in cutaneous lesions of lichen planus and discoid lupus erythematosus

Deyhimi

Keshani

Mohaghegh

et al. 2022

J Shahrekord Univ Med Sci

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Background and aims: Lichen planus (LP) and discoid lupus erythematosus (DLE) are two relatively common mucocutaneous lesions whose clinical and histopathological features overlap in some cases. The present study aimed to distinguish between these two lesions histopathologically in order to treat them more accurately. Methods: In a cross-sectional descriptive-analytical study, 29 and 48 microscopic slides of skin samples of DLE and LP, respectively, were examined in the pathology archive of Al-Zahra hospital of Isfahan from 2008 to 2018. The slides prepared by hematoxylin-eosin staining were examined simultaneously and blindly by three pathologists with a light microscope and compared according to certain histopathological criteria. Then obtained data were analyzed by SPSS version 24 using chi-square, Fisher’s exact, Mann-Whitney, and t tests (P<0.05). Results: Based on the findings, the presence of hyperparakeratosis with superficial hyperorthokeratosis, epithelial atrophy, deep perivascular infiltration, presence of edema in the papillary dermis, presence of plasma cells with lymphohistiocytes in inflammatory infiltration, and presence of mucin in the dermis were significantly higher in DLE than in LP (P<0.05). On the other hand, the intensity of lichenoid infiltration, presence of saw tooth hyperplasia of rete ridges, presence of cleft between the epithelium and connective tissue, spongiosis, hyperorthokeratosis alone, and wedge-shaped hypergranulosis were significantly higher in LP than in DLE (P<0.05). Conclusion: Perieccrine and perifollicular inflammation, presence of Civatte bodies (CBs), abundance of fibrosis, presence of pale keratinocytes, and presence of pseudoepitheliomatous hyperplasia were not the criteria for differential diagnosis of LP and DLE.

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Cutaneous lupus erythematosus/lichen planus overlap syndrome

Cited by 7 publications

References 23 publications

Lichen planus-lupus erythematosus overlap syndrome

Lichen planus-lupus erythematosus overlap syndrome

Skin lesions in systemic lupus erythematosus. Part 2: clinical and histological features

Comparative study of histopathological diagnostic criteria in cutaneous lesions of lichen planus and discoid lupus erythematosus

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