A Case of Foreign-Body Granuloma of the Glabella due to Polyacrylamide Filler and an Intractable Ulcer after Skin Biopsy: An Immunohistochemical Evaluation of Inflammatory Changes

Park, Kio; Nishiwaki, Fuyuko; Kabashima, Kenji

doi:10.1159/000353346

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…Therefore, despite the polyacrylamide hydrogel is not a complement activator it caused obvious FBR after implantation. Our observation is consistent to other researchers’ reports on the foreign-body granuloma of the glabella due to polyacrylamide filler 50 .…”

Section: Resultssupporting

confidence: 94%

Bio-inspired poly-DL-serine materials resist the foreign-body response

Zhang

Chen

et al. 2021

Nat Commun

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Implantation-caused foreign-body response (FBR) is a commonly encountered issue and can result in failure of implants. The high L-serine content in low immunogenic silk sericin, and the high D-serine content as a neurotransmitter together inspire us to prepare poly-DL-serine (PSer) materials in mitigating the FBR. Here we report highly water soluble, biocompatible and easily accessible PSer hydrogels that cause negligible inflammatory response after subcutaneous implantation in mice for 1 week and 2 weeks. No obvious collagen capsulation is found surrounding the PSer hydrogels after 4 weeks, 3 months and 7 months post implantation. Histological analysis on inflammatory cytokines and RNA-seq assay both indicate that PSer hydrogels show low FBR, comparable to the Mock group. The anti-FBR performance of PSer hydrogels at all time points surpass the poly(ethyleneglycol) hydrogels that is widely utilized as bio-inert materials, implying the potent and wide application of PSer materials in implantable biomaterials and biomedical devices.

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Section: Resultssupporting

confidence: 94%

Bio-inspired poly-DL-serine materials resist the foreign-body response

Zhang

Chen

et al. 2021

Nat Commun

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“…PAAG injections can cause short-term and long-term adverse reactions. Studies have shown that long-term implantation of PAAG for augmentation mammaplasty elicited foreign-body chronic inflammation and granulomatous reactions ( 7 , 9 , 10 ). Foreign-body granuloma formation and inflammatory cell infiltration are the characteristic histopathological features after cosmetic augmentation mammaplasty with an injection of PAAG.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous mastitis and pectoralis major muscle defect following polyacrylamide hydrogel injection: a case report and literature review

Xie,

Wan,

Shao

et al. 2024

AME Case Rep

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Background Breast augmentation through the injection of polyacrylamide hydrogel (PAAG) was a popular procedure in the past, but it has since been prohibited due to various complications, including masses, migration, infection, inflammation, and even cancer. However, there were rare cases of granulomatous mastitis with pectoralis major muscle defect following PAAG injection for breast augmentation. Case Description A 40-year-old female patient presented with a swollen and suppurative mass in her left breast and was insensitive to antibiotics. She was admitted to our department for further treatment after 7 months with progressive local and general symptoms. Ultrasound imaging showed ill-defined heterogeneous echoes, and contrast-enhanced magnetic resonance imaging (MRI) revealed non-mass enhancement lesions in the multiregional distribution in Breast Imaging-Reporting and Data System 4A (BI-RADS 4A) with oedema in the retroglandular space and multiple enlarged lymph nodes in the ipsilateral axilla. Intraoperative observations revealed necrotic tissues, multiple abscesses, residual mucoid PAAG prosthesis diffused into the mammary glands and intramuscularly into the pectoralis muscle, and partial loss of pectoralis major muscle. Histopathological results revealed foreign-body granulomas accompanied by gel-like granular PAAG and proliferative inflammatory cells. She recovered after undergoing the characteristic surgical management in our center under general anesthesia and had no recurrence during the 2-year follow-up. Conclusions This case revealed that PAAG injection for augmentation mammaplasty, even after the removal operation, could result in subsequent complications, including granulomatous mastitis and pectoralis major muscle damage. PAAG filler complications are difficult to treat, therefore, it is essential to establish appropriate and effective therapeutic procedures.

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“…Like PTFE and silicone, polyacrylate-polyalcohol copolymer and polyacrylamide hydrogel are non-biodegradable, meaning they can remain within the body permanently. They both have a favorable histopathologic profile, but foreign-body reactions are possible (117)(118)(119)(120). Polyacrylate-polyalcohol copolymer has been associated with risks of periureteral fibrosis (potentially complicating subsequent ureteral reimplantation) and obstruction of the vesicoureteral junction (116,121).…”

Section: Endoscopic Injectionmentioning

confidence: 99%

Management of Vesicoureteral Reflux: What Have We Learned Over the Last 20 Years?

et al. 2021

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Vesicoureteral reflux (VUR) is associated with increased risks of urinary tract infection, renal scarring and reflux nephropathy. We review advancements over the last two decades in our understanding and management of VUR. Over time, the condition may resolve spontaneously but it can persist for many years and bladder/bowel dysfunction is often involved. Some factors that increase the likelihood of persistence (e.g., high grade) also increase the risk of renal scarring. Voiding cystourethrography (VCUG) is generally considered the definitive method for diagnosing VUR, and helpful in determining the need for treatment. However, this procedure causes distress and radiation exposure. Therefore, strategies to reduce clinicians' reliance upon VCUG (e.g., after a VUR treatment procedure) have been developed. There are several options for managing patients with VUR. Observation is suitable only for patients at low risk of renal injury. Antibiotic prophylaxis can reduce the incidence of UTIs, but drawbacks such as antibiotic resistance and incomplete adherence mean that this option is not viable for long-term use. Long-term studies of endoscopic injection have helped us understand factors influencing use and the effectiveness of this procedure. Ureteral reimplantation is still performed commonly, and robot-assisted laparoscopic methods are gaining popularity. Over the last 20 years, there has been a shift toward more conservative management of VUR with an individualized, risk-based approach. For continued treatment improvement, better identification of children at risk of renal scarring, robust evidence regarding the available interventions, and an improved VUR grading system are needed.

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A Case of Foreign-Body Granuloma of the Glabella due to Polyacrylamide Filler and an Intractable Ulcer after Skin Biopsy: An Immunohistochemical Evaluation of Inflammatory Changes

Cited by 6 publications

References 11 publications

Bio-inspired poly-DL-serine materials resist the foreign-body response

Bio-inspired poly-DL-serine materials resist the foreign-body response

Granulomatous mastitis and pectoralis major muscle defect following polyacrylamide hydrogel injection: a case report and literature review

Management of Vesicoureteral Reflux: What Have We Learned Over the Last 20 Years?

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