A Case of Carcinomas of the Gallbladder, Common Bile Duct and Pancreas Associated With Anomalous Arrangement of the Pancreaticobiliary Ductal System

Ueda, Nobuhiko; Nagakawa, Takukazu; Ohta, Tetsuo; Tugawa, Kouichirou; Takeda, Tomoki; Kadoya, Naotaka; Kimura, Hironobu; Maeda, Keisuke; Kayahara, Masato; Ueno, Koichi; Izumi, Ryouhei; Miyazaki, Itsuo; Nonomura, Akitaka

doi:10.3919/ringe1963.49.2198

Cited by 5 publications

(5 citation statements)

References 5 publications

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“…There have been 27 reported cases (including ours) of cancer of the pancreas in patients who had pancreaticobiliary maljunction. Double cancer of the biliary tree and pancreas in patients with pancreaticobiliary maljunction has been reported in seven patients including ours (two cases were triple cancer of the gallbladder, the bile duct, and the pancreas) . (Table 1).…”

Section: Discussionmentioning

confidence: 66%

“…Double cancer of the biliary tree and pancreas in patients with pancreaticobiliary maljunction has been reported in seven patients including ours (two cases were triple cancer of the gallbladder, the bile duct, and the pancreas). [4][5][6][7][8][9] (Table 1). Gallbladder cancer was more frequent than bile duct cancer in patients with pancreas cancer who had pancreaticobiliary maljunction.…”

Section: Discussionmentioning

confidence: 99%

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Metachronous double cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction

Minami

Hasuike

Takeda

et al. 2008

J Hepatobiliary Pancreat Surg

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A 50-year-old Japanese woman complained of abdominal and back pain. Ten years previously she had undergone cholecystectomy, choledochectomy, and Roux-en-Y choledochojejunostomy for gallbladder cancer associated with pancreaticobiliary maljunction without bile duct dilatation. On the present admission, ultrasonography (US) and computed tomography (CT) demonstrated a large mass, 60 mm in size, in the pancreatic tail. Endoscopic retrograde cholangiopancreatography (ERCP) showed obstruction of the main pancreatic duct in the tail of the pancreas and revealed that the pancreatic duct was joined to the bile duct 25 mm above the papilla of Vater. The patient underwent distal pancreatectomy, splenectomy, left adrenalectomy, and partial gastrectomy. Histological examination revealed moderately differentiated ductal adenocarcinoma that had invaded to the proper muscle of the stomach. Double cancer of the gallbladder and pancreas in a patient with pancreaticobiliary maljunction is rare. Although the etiology of cancer of the pancreas associated with pancreaticobiliary maljunction is unclear, we should pay close attention to the pancreas as well as the biliary tract during the long-term follow-up of patients with pancreaticobiliary maljunction after they have undergone a choledochojejunostomy.

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Section: Discussionmentioning

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Metachronous double cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction

Minami

Hasuike

Takeda

et al. 2008

J Hepatobiliary Pancreat Surg

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“… Not described Unknown 3mo. death 10 Ueda, et al [28] ### 58M B Ic Whole pancreatic duct Intraductal pap. adenoca.…”

Section: Discussionmentioning

confidence: 99%

A case report of gallbladder cancer and pancreas cystic neoplasm associated with pancreaticobiliary maljunction

Sato

Ito

Masaki

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Pancreaticobiliary maljunction (PBM) is a rare congenital anomaly that is frequently associated with carcinoma of the biliary tract. However, there is still no clear evidence that PBM is associated with pancreatic tumors. Here we describe a case of gallbladder cancer and intraductal papillary mucinous neoplasm (IPMN) that is associated with PBM. Case presentation A 72-year-old man underwent a cholecystectomy with hepatectomy (S4a + S5) and regional lymph node dissection for gallbladder adenocarcinoma invading the front lobe branch of the hepatic artery. A pylorus-preserving pancreaticodudenectomy was also performed for pancreatic IPMN. Clinical discussion Presence of mucin type 6 (MUC6) -positive pyloric gland metaplasia in both the dilated pancreatic duct and the gallbladder background mucosa suggests that pancreatic IPMN and gallbladder cancer may have a common phenotypic origin. Additionally, analysis of 41 reported cases of pancreatic cancer associated with PBM revealed that in all metachronous multiple cancer cases, biliary tract cancer preceded the pancreatic cancer with congenital biliary dilatation accompanied by PBM. The analysis also revealed an increased proportion of pancreatic cancer cases with PBM in patients who had not undergone a flow diversion procedure located in pancreatic head. Conclusion We show an interesting relationship between pancreatic/gallbladder cancer and PBM. More comprehensive evaluations of the whole pancreaticobiliary system in follow-up of patients with PBM is required to understand the full extent of this relationship.

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“…There are only 12 reported cases of pancreatic cancer occurring in association with a choledochal cyst or PBM (Table 1). [5][6][7][8][9][10][11][12][13][14][15] These patients consisted of seven women and five men ranging in age from 15 to 75 years (mean 44.3 years). They were younger in age and the frequency was higher in women than in patients with the more common type of pancreatic cancer because choledochal cyst is most often encountered in young women.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma Arising in the Pancreas 17 Years After Primary Excision of a Choledochal Cyst: Report of a Case

Eriguchi¹,

Aoyagi²,

Okuda³

et al. 2001

Surgery Today

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We report herein the case of a 42-year-old woman in whom a pancreatic carcinoma was found 17 years after excision of a choledochal cyst with Roux-en-Y hepaticojejunostomy. Although the incidence of biliary carcinoma associated with choledochal cyst is high, reports of cancer developing in the remaining intrapancreatic biliary tract or pancreas in patients who have previously undergone primary excision of a choledochal cyst are extremely rare. Long-term follow-up is recommended even for patients who have undergone excisional surgery for a choledochal cyst, in consideration of the possibility that cancer associated with the intrapancreatic biliary tract or pancreas may develop.

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A Case of Carcinomas of the Gallbladder, Common Bile Duct and Pancreas Associated With Anomalous Arrangement of the Pancreaticobiliary Ductal System

Cited by 5 publications

References 5 publications

Metachronous double cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction

Metachronous double cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction

A case report of gallbladder cancer and pancreas cystic neoplasm associated with pancreaticobiliary maljunction

Carcinoma Arising in the Pancreas 17 Years After Primary Excision of a Choledochal Cyst: Report of a Case

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