Metachronous double cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction

Minami, Yasunori; Hasuike, Yasunori; Takeda, Yutaka; Tsujinaka, Toshimasa

doi:10.1007/s00534-007-1208-7

Cited by 18 publications

(18 citation statements)

References 6 publications

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“…Between 1957 and 2008, there were only 35 cases in which pancreatic cancer was reported in patients with PBM [99][100][101]. While the incidence of pancreatic cancer was reported to be 0.0162 % in the overall population in Japan, in patients with PBM this incidence reached 0.8 %, a 49.4-fold increase compared with that in the overall population [102].…”

Section: Commentsmentioning

confidence: 99%

Japanese clinical practice guidelines for pancreaticobiliary maljunction

et al. 2012

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There have been no clinical guidelines for the management of pancreaticobiliary maljunction (PBM). The Japanese Study Group on Pancreaticobiliary Maljunction (JSPBM) has proposed to establish clinical practice guidelines on how to deal with PBM, with the support of the Japan Biliary Association (JBA). Because the body of evidence-based literature is relatively small, we decided to create guidelines based on the consensus of experts, using the medical literature for reference. A total of 46 clinical questions (CQs) were considered by the members of the editorial committee responsible for the guidelines. The CQs covered distinct aspects of PBM: (1) Concepts and Pathophysiology (10 CQs); (2) Diagnosis (10 CQs); (3) Pancreatobiliary complications (9 CQs); and (4) Treatments and prognosis (17 CQs). Statements and comments for each CQ were prepared by the guidelines committee members and collaborating partners. The CQs were completed after review by members of the editorial committee, meetings of this committee, public comments on the homepages of the JSPBM and the JBA, public hearings, and assessment and approval by the guidelines evaluation board. PBM includes cases where the bile duct is dilated (PBM with biliary dilatation) and those in which it is not (PBM without biliary dilatation). In these guidelines, PBM with biliary dilatation is defined as being identical to congenital biliary dilatation of Todani type I (except for type Ib) and type IV-A, both of which are accompanied by PBM in almost all cases. These guidelines are created to provide assistance in the clinical practice of PBM management; their contents focus on clinical utility, and they include general information on PBM to make this disease more widely recognized.

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Section: Commentsmentioning

confidence: 99%

Japanese clinical practice guidelines for pancreaticobiliary maljunction

et al. 2012

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“…However, the relationship between pancreatic cancer and PBM remains controversial and unclear. In addition, cases of double cancer of the biliary system and the pancreas is extremely rare in patients with PBM (8,(10)(11)(12), despite occasional reports of multiple cancers of the biliary system in patients with PBM (3)(4)(5). The present case suggested that careful attention should be paid to the whole pancreaticobiliary system with regard to carcinogenesis, however, further case studies are needed.…”

Section: Discussionmentioning

confidence: 67%

“…The definitive distinction between multicentric primary cancers and gallbladder cancer metastases is difficult. Although biliary cancer in patients with PBM is occasionally encountered, pancreatic cancers in patients with PBM are rare (8)(9)(10)(11)(12). Funabiki et al (13) reported that the incidence of pancreatic cancer is higher in patients with PBM than in patients without PBM.…”

Section: Discussionmentioning

confidence: 99%

Multiple Cancers of the Biliary Tract and Pancreatic Duct after Cholecystectomy for Gallbladder Cancer in a Patient with Pancreaticobiliary Maljunction

et al. 2016

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We herein report the rare case of a 76-year-old woman who underwent cholecystectomy with bile duct resection for advanced gallbladder cancer associated with pancreaticobiliary maljunction (PBM) and subsequently developed multiple cancers of the pancreaticobiliary system (the distal bile duct, intrahepatic duct and pancreatic duct) after the operation. We performed conventional endoscopic retrograde cholangiopancreatography (ERCP) using a side-viewing scope to evaluate the masses in the distal bile duct and the pancreatic duct. We also performed ERCP using double-balloon enteroscopy (DBE) to observe the mass in the intrahepatic duct. It was possible to directly observe the lesion using DBE and to perform a biopsy under visual control. All lesions were correctly diagnosed by the combination of ERCP using different endoscopes. The present case suggests that it is necessary to pay close attention (with regard to carcinogenesis) to the whole pancreaticobiliary system in patients with PBM. In addition, the combination of ERCP using DBE and a side-viewing scope may be useful for making a precise diagnosis in patients with altered biliary anatomy who have multiple cancers of the pancreaticobiliary system.

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“…Multifocal cancer of the biliary tree and pancreas associated with pancreaticobiliary maljunction has been reported in 7 patients (two cases were triple cancer of the gallbladder, the bile duct and the pancreas) [46] and six of them were women. In the seven patients, the cancer of the gallbladder occurred previously or synchronously with the pancreatic cancer [7] . Gallbladder cancer was more frequent than bile duct cancer [7] .…”

Section: Discussionmentioning

confidence: 99%

“…In the seven patients, the cancer of the gallbladder occurred previously or synchronously with the pancreatic cancer [7] . Gallbladder cancer was more frequent than bile duct cancer [7] . Three patients had bile duct dilatation and none presented a choledochal cyst.…”

Section: Discussionmentioning

confidence: 99%

Metachronous cancer of gallbladder and pancreas with pancreatobiliary maljunction

Lahmar

Abid²,

Arfa³

et al. 2010

WJGS

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Pancreaticobiliary maljunction is a congenital anomaly in which the junction between the pancreatic duct and the common bile duct is located outside the sphincter of Oddi. It is well known that pancreaticobiliary maljunction is frequently associated with carcinoma of the biliary tract. We report a case of metachronous cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction and cystic dilatation of common bile duct in a 68-year-old Tunisian woman who underwent a cholecystectomy for acute cholecystitis. The pancreatic tumor was an adenosquamous carcinoma. Pancreaticobiliary maljunction allows for pancreatobiliary or biliopancreatic reflux which may induce biliary tract carcinoma. Few cases of multifocal cancer associated with this anomaly have been reported. The association with pancreatic carcinoma remains rare. Close attention should be given to both the biliary tract system and pancreas during the long-term follow-up of patients with pancreaticobiliary maljunction, especially after they have undergone a choledochojejunostomy.

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Metachronous double cancer of the gallbladder and pancreas associated with pancreaticobiliary maljunction

Cited by 18 publications

References 6 publications

Japanese clinical practice guidelines for pancreaticobiliary maljunction

Japanese clinical practice guidelines for pancreaticobiliary maljunction

Multiple Cancers of the Biliary Tract and Pancreatic Duct after Cholecystectomy for Gallbladder Cancer in a Patient with Pancreaticobiliary Maljunction

Metachronous cancer of gallbladder and pancreas with pancreatobiliary maljunction

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