A case of basal cell carcinoma of the nipple and areola with intraductal spread

Abstract

We report an 82-year-old Japanese woman with basal cell carcinoma of the left nipple and areola extending into the lactiferous duct. The patient developed a small papular lesion of the left areola about 1 year before admission. The lesion, which had slowly progressed to involve the nipple, had become symptomatic showing weeping and bleeding. Mammography revealed microcalcification in the nipple. Although Paget's disease was suspected from these clinical features, histologically basal cell carcinoma was diagnosed. There was no axillary lymphadenopathy, and no evidence of distant metastasis. The lesion of the nipple and areola was resected with a 2 cm free margin along with the underlying mammary tissue. The patient has remained well without signs of recurrence for 2 years after surgery. We reviewed cases of basal cell carcinoma of the nipple or areola and discuss considerations and problems of this rare tumor.

Metastatic Basal Cell Carcinoma: Report of Two Cases and Literature Review

“…Primary MBCC occurred on the faces of our patients, which is consistent with previous reports of non-MBCC occurring predominantly in sun-exposed areas of the head and neck. 20 Atypical sites for primary lesions of MBCC include the abdomen, axilla 25,26 esophagus, 4 nipple, 27 penis and/or scrotum, 28,29 vulva, 30,31 and dura.…”

Secondary Intention Healing following Mohs Micrographic Surgery for Basal Cell Carcinoma of the Nipple and Areola*

“…Involutional changes and dermal thickening on mammography were found in one infiltrating BCC (6). Microcalcifications were found in one invasive BCC (8), while the other case showing calcifications in the areola on mammography did not report any histological details (23).…”

“…Of these, five were normal (4,5,7,10,11), two revealed calcification (8,23) and one had involutional changes and dermal thickening (6). Two patients with infiltrative BCCs (4,5) and one patient with BCC invading the lactiferous ducts (7) had normal mammograms.…”

One more common tumor in an uncommon location: Squamous cell carcinoma on nipple areola complex

“…[3] Cases of basal cell carcinomas are also seen and have been reported in the literature, [4,5] but the total number of cases documented on squamous cell carcinoma especially arising from the nippleareola complex are very limited. [3] Cases of basal cell carcinomas are also seen and have been reported in the literature, [4,5] but the total number of cases documented on squamous cell carcinoma especially arising from the nippleareola complex are very limited.…”

“…[3,4] These techniques include karyotypic analysis, X-chromosome inactivation assay, [3,4] These techniques include karyotypic analysis, X-chromosome inactivation assay,…”