One more common tumor in an uncommon location: Squamous cell carcinoma on nipple areola complex

A common cancer in an uncommon location: A case report of squamous cell carcinoma of the nipple

“…Surgical resection either as a wide localized excision or mastectomy was used in most cases as well as in our own patient [3], [4], [5], [6], [7], [8], [9], [10], [11]. Prognosis seen in the other cases that were managed promptly is good, with patients in other cases being tumor free for at least five years [9].…”

“…The current literature exhibited a wide range of approaches in treatment but as in cutaneous SCC, a wide local excision has been the primary choice but mastectomy and photodynamic therapy was also reported [3], [4], [5], [6], [7], [8], [9], [10], [11]. Of the cases only two reported local reoccurrence, one of the cases was treated via an incomplete local resection that was corrected with repeat resection and the other case was initially treated with a photosensitizer and retreated with cryotherapy [3], [4], [5], [6], [7], [8], [9], [10], [11]. Of the cases with no reported reoccurrence, patients were SCC free for six months up to five years as reported in one of the cases with mastectomy [5], [9].…”

“…SCC specifically is the second most prevalent of the two [2]. However it is rarely seen on the nipple as can be seen in the limited number of case reports seen in literature which at last count was ten cases [3], [4], [5], [6], [7], [8], [9], [10], [11]. Paget’s disease of the breast (PDB) on the other hand while rare itself is the most common malignancy of the nipple areola complex [12].…”

Primary Invasive Squamous Cell Carcinoma of the Nipple

“…Of the nine reported cases, three were in situ [ 4 , 7 , 8 ] and one showed <1 mm of invasion [ 5 ]. Six carcinomas (in situ or invasive) occurred in postmenopausal women ranging in age from 62 to 87 years [ 3 – 6 , 8 ] and one invasive carcinoma was found in a 62-year-old male [ 2 ]. Of the two cases reported in younger patients, one was in a 41-year-old male who was HIV positive (in situ) [ 7 ] and one was in a 34-year-old female (invasive) [ 1 ].…”

“…In the previously reported cases of squamous cell carcinoma of the nipple, two patients presented with an exophytic mass [ 5 , 6 ]. In the remaining patients, physical examination revealed scaling, erythema, and/or ulceration, which raised the possibility of Paget disease of the nipple, a much more common entity [ 1 – 4 , 7 , 8 ].…”