A case of adenomatoid odontogenic tumor: A histochemical and electron microscopic study.

Kinoshita, Yukihiko; Shimura, Kaizo; Honma, Yoshiro; Shimozato, Makoto; Yamaguchi, Kazufumi; Hirai, Eiichi; Shimura, Tsutomu

doi:10.5794/jjoms.31.1775

Cited by 2 publications

(2 citation statements)

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“…In histochemical studies on the AOT attention has mainly been paid to the nature of the hyaline or eosinophilic deposits and calcified structures (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The fact that some investigators consider the eosinophilic material to be an abortive form of preenamel while others are equally convinced that it represents some type of mesenchymal product clearly expresses the inadequacy of previous "conventional" histochemical techniques.…”

Section: Ihistochemlcal Findingsmentioning

confidence: 99%

“…Since the first description by Takagi (20), the AOT has repeatedly been studied at the ultrastructural level (12,16,20,(23)(24)(25)(26)(27)(28)(29)(30)(31). Most of the specimens examined have, however, been retrieved from reprocessed formalin-fixed and paraffin embedded material and almost all studies have been performed on the follicular variant of the AOT.…”

Section: Ultrastructurai Findingsmentioning

confidence: 99%

See 1 more Smart Citation

Adenomatoid odontogenic tumor: biologic profile based on 499 cases

Philipsen

Reichart

Zhang

et al. 1991

J Oral Pathology Medicine

232

185

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Topographically, the AOT occurs in peripheral and central variants, the latter further in follicular (with embedded tooth) and extrafollicular (no embedded tooth) types. The AOT is slow growing with few or no symptoms. Tumor growth may cause displacement of teeth rather than root resorption. The follicular AOT mimics a follicular cyst, the extrafollicular a residual or "globulo-maxillary" cyst and the peripheral a gingival fibroma. All variants of AOT show identical histologic features. The central variants account for 97.2%, 73.0% of which are follicular. The follicular variant (M:F ratio 1 to 1.9) is three times as frequent as the extrafollicular. The follicular variant is diagnosed earlier in life (mean age 17 yr) than the extrafollicular (mean age 24 yr). 53.1% of all variants occur within the teens (13-19 yr). Follicular AOT is associated with one embedded tooth in 93.2%. Maxillary permanent canines account for 41.7% and all four canines for 60.1% of AOT-associated embedded teeth. Ranking four among the odontogenic tumors the AOT is not a particularly rare tumor. Conservative surgical excision is the treatment of choice. Documented recurrences have not been reported.

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Section: Ihistochemlcal Findingsmentioning

confidence: 99%

Section: Ultrastructurai Findingsmentioning

confidence: 99%

Adenomatoid odontogenic tumor: biologic profile based on 499 cases

Philipsen

Reichart

Zhang

et al. 1991

J Oral Pathology Medicine

232

185

View full text Add to dashboard Cite

show abstract

The adenomatoid odontogenic tumour: ultrastructure of tumour cells and non‐calcified amorphous masses

Philipsen

Reichart

1996

J Oral Pathology Medicine

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The ultrastructure of tumour cells and tumour droplets (TD, non-calcified amorphous masses) was studied in three cases of AOT using freshly prepared tissue. The fine structure of the epithelial tumour cells (cell type I-III) corresponded to that of earlier descriptions. The extracellular location of TD was clearly demonstrated. TD were of varying, sometimes bizarre, configuration. Some TD showed a homogeneous matrix; however, in addition most revealed electron-dense plaques. At high magnification, homogeneous types of TD showed only tubular elements; all others revealed granulo-tubular structures. The tubular elements were arranged concentrically. The nature of the TD is discussed and compared to former interpretations. From the present ultrastructural findings, it appears that the TD most probably represent some form of enamel matrix and as such may be considered a type of pre-enamel. Further studies are needed to elucidate the complex structure of the TD-material so characteristic of the AOT.

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A case of adenomatoid odontogenic tumor: A histochemical and electron microscopic study.

Cited by 2 publications

References 13 publications

Adenomatoid odontogenic tumor: biologic profile based on 499 cases

Adenomatoid odontogenic tumor: biologic profile based on 499 cases

The adenomatoid odontogenic tumour: ultrastructure of tumour cells and non‐calcified amorphous masses

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