Adenomatoid odontogenic tumor: biologic profile based on 499 cases

Abstract

Topographically, the AOT occurs in peripheral and central variants, the latter further in follicular (with embedded tooth) and extrafollicular (no embedded tooth) types. The AOT is slow growing with few or no symptoms. Tumor growth may cause displacement of teeth rather than root resorption. The follicular AOT mimics a follicular cyst, the extrafollicular a residual or "globulo-maxillary" cyst and the peripheral a gingival fibroma. All variants of AOT show identical histologic features. The central variants account for 97.2%, 73.0% of which are follicular. The follicular variant (M:F ratio 1 to 1.9) is three times as frequent as the extrafollicular. The follicular variant is diagnosed earlier in life (mean age 17 yr) than the extrafollicular (mean age 24 yr). 53.1% of all variants occur within the teens (13-19 yr). Follicular AOT is associated with one embedded tooth in 93.2%. Maxillary permanent canines account for 41.7% and all four canines for 60.1% of AOT-associated embedded teeth. Ranking four among the odontogenic tumors the AOT is not a particularly rare tumor. Conservative surgical excision is the treatment of choice. Documented recurrences have not been reported.

Adenomatoid Odontogenic Tumor: Retrospective Study of 15 Cases with Emphasis on Histopathologic Features

“…It has been generally reported that AOT corresponds to 2.2-8.7 % of all odontogenic tumors [2,10,19]. However, in a worldwide collaborative retrospective study, the relative frequency of AOT ranged from 0.6 to 38.5 % [4].…”

“…Between the epithelial cells and in the center of the rosette-like structures, eosinophilic amorphous material (often described as 'tumor droplets') is present. Additionally, variably amounts of calcified material are present in most lesions [10].…”

Peripheral adenomatoid odontogenic tumor: report of a rare case

“…4 Adenomatoid odontogenic tumor affects females more frequently than males in a ratio of 1.9:1. 2 This ratio may be even higher as reported in Asian populations, the highest incidence being observed in Sri Lanka, 3.2:1 5 and Japan, 3:1.…”

“…4 Recurrence of the tumor is very rare and the prognosis is excellent. In our case, the tumor was completely enucleated along with its capsule.…”

“…Asian AOT cases show a male: female ratio of 1-2.3 vs 1-1.4 for non-Asian cases. 4 There are three clinicopathologic variants of AOT namely intrafollicular, extrafollicular, and peripheral, all with identical histologies. 2 The peripheral type is the rarest of them all constituting only 3% of all AOTs.…”