A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast

Noda, Haruna; Yamashita, Michiko; Murakami, Akari; Okujima, Kumiko; Takemoto, Kana; Takaoka, Megumi; Kusakabe, Erina; Aoki, Reina; Taguchi, Kana; Nishiyama, Kanako; Kitazawa, Riko; Kamei, Yasuhiro; Takada, Yasutsugu

doi:10.1159/000518244

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Malignant squamous transformation is known to develop in wounds involved with chronic inflammation. However, there is no experimental or clinical evidence to support expected findings of epithelialization of the implant capsule and subsequent squamous dysplasia in the pathologic evaluation of capsulectomy specimens ( 13 – 15 ). In this case study, we present a rare case of SCC of the breast with a rare mechanism of onset.…”

Section: Discussionmentioning

confidence: 95%

Breast implant-associated squamous cell carcinoma in a male patient: A case report and review of the medical literature

et al. 2023

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BackgroundPrimary squamous cell carcinoma (SCC) of the breast is a rare tumor type. The diagnosis of this tumor type is more frequently made only after microscopy evaluation. Breast implant-associated SCC is rarer with medical literature review indicating only 18 cases reported in female individuals.Case presentationWe reported an unusual case that a man found a 3-cm sized mass on his left breast at first, who had a implant surgery 18 years previously to reconstruct the deformed left breast, as related to the Poland's syndrome. More than 1 year after the mass was detected, the size of the mass gradually increased to 20 cm with swelling and severe pain, and the patient was admitted to our hospital. The patient underwent surgical excision of the tumor, followed by removal of the implant, complete capsulectomy, and sentinel lymph node biopsy. The microscopy evaluation demonstrated the tumor as moderately and poorly differentiated invasive SCC. Follow-up at 12 months after showed multiple metastases, including the skin of the chest, axillary lymph nodes and pleura.ConclusionBreast implant-associated SCC can occur in male patients. Therefore, it should be considered when the clinical manifestation or histopathological appearance is not typical of other breast neoplasms. Malignant transformation of normal epithelial cells takes about 18 years, after which rapid evolution follows leading to fast growth of the tumor.

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Section: Discussionmentioning

confidence: 95%

Breast implant-associated squamous cell carcinoma in a male patient: A case report and review of the medical literature

et al. 2023

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Significant efficacy of paclitaxel plus carboplatin (TP) as a neoadjuvant regimen for metaplastic squamous cell carcinoma of the breast: a rare case report and literature review

Chen¹,

Jiang²,

Luo³

et al. 2022

Transl Cancer Res TCR

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Background: Metaplastic squamous cell carcinoma of the breast (MSCCB) is a rare and aggressive type of cancer. So far, no standard treatment regimen has been established due to the absence of clinical data.Case Description: We report a case of a 48-year-old female admitted to our hospital as a result of a left breast mass with skin rupture. Core needle biopsy under ultrasonic guidance confirmed MSCCB.Immunohistochemistry revealed negative staining for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor type 2 (HER2/neu). After receiving 4 cycles of paclitaxel and carboplatin neoadjuvant chemotherapy, the patient was treated with modified radical mastectomy.Postoperative pathology revealed a Miller-Payne score of 4 and no metastasis in the axillary lymph nodes (0/13), indicating a good response to neoadjuvant chemotherapy. She recovered well post-surgery and was discharged to home after admission. No recurrence was identified during the 2 years post-surgery follow-up.Conclusions: MSCCB is a rare and aggressive type of cancer. However, the treatment of MSCCB has not been standardized due to its rarity. Given the observation that the majority of patients with MSCCB had ER, PR, HER2-negative neoplasms, we refer to the triple negative breast cancer (TNBC) treatment protocol.TP regimen was demonstrated to be an effective treatment for TNBC. The results of this case suggest that the TP regimen is effective in neoadjuvant chemotherapy of MSCCB.

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A Case of a Rapidly Growing Granulocyte Colony-Stimulating Factor-Producing Squamous Cell Carcinoma of the Breast

Cited by 2 publications

References 8 publications

Breast implant-associated squamous cell carcinoma in a male patient: A case report and review of the medical literature

Breast implant-associated squamous cell carcinoma in a male patient: A case report and review of the medical literature

Significant efficacy of paclitaxel plus carboplatin (TP) as a neoadjuvant regimen for metaplastic squamous cell carcinoma of the breast: a rare case report and literature review

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