A carbonized wormwood modified photothermal microneedle patch for the repair of damaged skeletal muscles

Zhang, Chuxi; Jia, Shuang; Huang, Jianguo; Peng, Haichuan; Zhang, Jiao; Liu, Lubing; Zhang, Wei; Xin, Hong‐Bo; Wang, Xiaolei

doi:10.1039/d1tb00610j

Cited by 11 publications

(14 citation statements)

References 28 publications

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“…Zhang et al designed PVAbased soluble microneedles containing carbonized wormwood (a photothermal agent) and prostaglandin E2 (PGE2) to achieve a synergistic effect of photothermal therapy and drug treatment. [56] Under 808 nm near-infrared (NIR) irradiation, the temperature of microneedles raised quickly and steadily, exerting thermal therapeutic effect and accelerating drug release. Surgical muscle damage experiments showed more than 90% of muscle strength recovery in PGE2 + NIR group.…”

Section:  Repairing Injured Skeletal Musclementioning

confidence: 99%

Microneedle system for tissue engineering and regenerative medicine

Zhang

Kong

et al. 2023

Exploration

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Global increasing demand for high life quality and length facilitates the development of tissue engineering and regenerative medicine, which apply multidisciplinary theories and techniques to achieve the structural reconstruction and functional recovery of disordered or damaged tissues and organs. However, the clinical performances of adopted drugs, materials, and powerful cells in the laboratory are inescapably limited by the currently available technologies. To tackle the problems, versatile microneedles are developed as the new platform for local delivery of diverse cargos with minimal invasion. The efficient delivery, as well as painless and convenient procedure endow microneedles with good patient compliance in clinic. In this review, we first categorize different microneedle systems and delivery models, and then summarize their applications in tissue engineering and regenerative medicine mainly involving maintenance and rehabilitation of damaged tissues and organs. In the end, we discuss the advantages, challenges, and prospects of microneedles in depth for future clinical translations.

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Section:  Repairing Injured Skeletal Musclementioning

confidence: 99%

Microneedle system for tissue engineering and regenerative medicine

Zhang

Kong

et al. 2023

Exploration

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“…Differently, MNs can directly reach the dermis, where there is abundant blood flow, and can better deliver various kinds of drugs from micromolecules to macromolecules and hydrophilic drugs to hydrophobic ones. They also allow the drugs to permeate to the target site such as bones, 25 joint cavity 26 and skeletal muscle 27 nearby and reach the effective concentration. In addition, the operation of MNs in the drug delivery process, either with bare hands or with an applicator, is relatively simple, freeing from additional auxiliary equipment and professionals, which has great potential in the TDD of the MSK system.…”

Section: Anatomy Foundation and Characteristics Of Mns For Tdd In The...mentioning

confidence: 99%

Transdermal drug delivery via microneedles for musculoskeletal systems

Zheng¹,

Xie²,

Ling³

et al. 2023

J. Mater. Chem. B

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“…In Zhang's study, he used PVP MNs loaded with carbonized wormwood and prostaglandin G2 (PEG2) to repair skeletal muscle damage (Figure 11c). [ 167 ] Like other previous NIR responsive MNs, carbonized wormwood also heats the MNs under infrared light to promote the release of PEG2. The difference is that in vivo experiments, the carbonized wormwood + PEG2 group exhibited superior induction of muscle stem cell proliferation and differentiation to repair damaged muscle tissue under heat therapy compared to the group without carbonized wormwood.…”

Section: The Applications Of Intelligent Stimulus‐responsive Mnsmentioning

confidence: 99%

Section: Light-responsive Mnsmentioning

confidence: 99%

Advances in Intelligent Stimuli‐Responsive Microneedle for Biomedical Applications

Weng

et al. 2023

Macromolecular Bioscience

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Microneedles (MNs) are a new type of drug delivery method that can be regarded as an alternative to traditional transdermal drug delivery systems. Recently, MNs have attracted widespread attention for their advantages of effectiveness, safety, and painlessness. However, the functionality of traditional MNs is too monotonous and limits their application. To improve the efficiency of disease treatment and diagnosis by combining the advantages of MNs, the concept of intelligent stimulus‐responsive MNs is proposed. Intelligent stimuli‐responsive MNs can exhibit unique biomedical functions according to the internal and external environment changes. This review discusses the classification and principles of intelligent stimuli‐responsive MNs, such as magnet, temperature, light, electricity, reactive oxygen species, pH, glucose, and protein. This review also highlights examples of intelligent stimuli‐responsive MNs for biomedical applications, such as on‐demand drug delivery, tissue repair, bioimaging, detection and monitoring, and photothermal therapy. These intelligent stimuli‐responsive MNs offer the advantages of high biocompatibility, targeted therapy, selective detection, and precision treatment. Finally, the prospects and challenges for the application of intelligent stimuli‐responsive MNs are discussed.

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A carbonized wormwood modified photothermal microneedle patch for the repair of damaged skeletal muscles

Abstract: In this study, we aimed to achieve an efficient repair of damaged skeletal muscles using polyvinyl alcohol (PVA) soluble microneedle patches (MNP) loaded with carbonized wormwood and prostaglandin E2 (inflammatory factors).

Cited by 11 publications

References 28 publications

Microneedle system for tissue engineering and regenerative medicine

Microneedle system for tissue engineering and regenerative medicine

Transdermal drug delivery via microneedles for musculoskeletal systems

Advances in Intelligent Stimuli‐Responsive Microneedle for Biomedical Applications

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