A Butenolide from the Marine Sponge Callyspongia vaginalis

Layne, Tanya H.; Tinto, Winston F.

doi:10.3987/com-06-10823

Cited by 10 publications

(5 citation statements)

References 9 publications

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“…[4] Ar ange of structurally diverse natural products have been isolated from sponges of the Callyspongia genera (Figure 1), with many exhibiting potentiallyu seful biological activities. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]…”

Section: Isolationmentioning

confidence: 99%

“…Belonging to the Callyspongiidae family, Callyspongia are a genera of sea sponge, which are commonly found inhabiting mesophonic reefs in oceans worldwide [4] . A range of structurally diverse natural products have been isolated from sponges of the Callyspongia genera (Figure 1), with many exhibiting potentially useful biological activities [5–22] …”

Section: Introductionmentioning

confidence: 99%

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The Synthesis and Bioactivity of the Marine Macrolide Callyspongiolide

Wilson

Brimble

2020

Chemistry A European J

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Callyspongiolide, a macrolide natural product with a conjugated diene‐ynic side chain, has garnered significant attention from the synthetic community since its isolation from a sea sponge in 2013. Herein, the approaches that have been applied to this bioactive natural product to date are reviewed. These synthetic endeavors have established the absolute stereochemistry of this molecule and allowed further investigation into its promising caspase‐independent bioactivity, while also contributing to the wider field of macrolide synthesis.

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Section: Isolationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Synthesis and Bioactivity of the Marine Macrolide Callyspongiolide

Wilson

Brimble

2020

Chemistry A European J

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“…More than 60 species are widely distributed in the tropical sea [ 5 ]. It is also found in the Indian, Western Atlantic, and Eastern Pacific oceans, including Indonesia [ 6 ], the Red sea [ 7 , 8 ], Cuba [ 4 ], Barbados [ 9 ], Brazil [ 10 , 11 ], and Ecuador [ 12 ]. At a depth of 6–10 m below sea level, Callyspongia spp.…”

Section: Introductionmentioning

confidence: 99%

Callyspongia spp.: Secondary Metabolites, Pharmacological Activities, and Mechanisms

et al. 2023

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One of the most widespread biotas in the sea is the sponge. Callyspongia is a sponge genus found in the seas, making it easily available. In this review, the pharmacological activity and mechanism of action of the secondary metabolites of Callyspongia spp. are addressed, which may lead to the development of new drugs and targeted therapeutic approaches. Several scientific databases, such as Google Scholar, PubMed, ResearchGate, Science Direct, Springer Link, and Wiley Online Library, were mined to obtain relevant information. In the 41 articles reviewed, Callyspongia spp. was reported to possess pharmacological activities such as cytotoxicity against cancer cell lines (36%), antifungal (10%), anti-inflammatory (10%), immunomodulatory (10%), antidiabetic and antiobesity (6%), antimicrobial (8%), antioxidant (4%), antineurodegenerative (4%), antihypercholesterolemic (2%), antihypertensive (2%), antiparasitic (2%), antiallergic (2%), antiviral (2%), antiosteoporotic (2%), and antituberculosis (2%) activities. Of these, the antioxidant, antituberculosis, and anti-inflammatory activities of Callyspongia extract were weaker compared with that of the control drugs; however, other activities, particularly cytotoxicity, show promise, and the compounds responsible may be developed into new drugs.

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“…Callyspongia are a genera of sea sponge organisms belonging to the Callyspongiidae family, which are commonly found to inhabit mesophonic reefs across the world's oceans. [1] Over the course of decades, sponges of this genus have provided the scientific community with a plethora of structurally unique and biologically active natural products, including polyketides, [2] polyacetylenes, [3,4] alkaloids, [5][6][7] terpenoids, [8,9] fatty acids, [10] sterols, [11,12] peroxides, [13] butenolides, [14] and cyclic peptides. [15][16][17] Many of these metabolites are shown to possess a wide range of biological activities including cytotoxic, [18] anticancer, [2] and antimicrobial and antifouling properties.…”

Section: Introductionmentioning

confidence: 99%