Abstract:Callyspongiolide, a macrolide natural product with a conjugated diene‐ynic side chain, has garnered significant attention from the synthetic community since its isolation from a sea sponge in 2013. Herein, the approaches that have been applied to this bioactive natural product to date are reviewed. These synthetic endeavors have established the absolute stereochemistry of this molecule and allowed further investigation into its promising caspase‐independent bioactivity, while also contributing to the wider fie… Show more
Integration of chemical synthesis, NMR spectroscopy, and various analytical means is key to success in the structure elucidation of stereochemically complex marine macrolide natural products.
Integration of chemical synthesis, NMR spectroscopy, and various analytical means is key to success in the structure elucidation of stereochemically complex marine macrolide natural products.
Impacts of meta-connectivity and pendant groups are robust parameters controlling the destructive quantum interference (DQI) and improve thermoelectric properties of meta-OPE molecules making them suitable materials for thermoelectric applications.
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