Inflamasi merupakan respon normal tubuh mengenali rangsangan berbahaya. Berdasarkan data dariRiskesdas pada tahun 2018 bahwa proporsi untuk luka bakar sebesar 1,3 untuk Indonesia dan palingbesar terjadi di Papua dengan proporsi sebesar 3. Daun sirsak (Annona muricata L.) menjadi salahsatu inovasi sekaligus solusi untuk mengatasi penanganan luka bakar yang terus meningkat. Metodepenelitian yang dilakukan adalah pencarian literatur atau studi pustaka dengan kata kunci “Annonamuricata L.”, “Anti Inflammatory Activity of Annona muricata L.”, dan “inflammation in burns” dengantahun publikasi 10 tahun terakhir dari situs valid seperti Google schoolar dan Pubmed. Literatur yangmemenuhi kriteria inklusi berjumlah 10 artikel ilmiah. Diperlukan pengkajian atau penelusuran senyawabioaktif yang dapat dimanfaatkan sebagai antiinflamasi pada luka bakar pada daun sirsak. Hasildari review ini adalah aktivitas antiinflamasi daun sirsak dipengaruhi oleh kandungan senyawa fenol,alkaloid dan senyawa lainnya yang berperan sebagai antioksidan alami yang telah teruji secara invitro dan in vivo sehingga dapat dimanfaatkan sebagai herba potensial dalam mengatasi luka bakardengan mekanisme sebagai antioksidan dan penghambatan mediator inflamasi.
One of the most widespread biotas in the sea is the sponge. Callyspongia is a sponge genus found in the seas, making it easily available. In this review, the pharmacological activity and mechanism of action of the secondary metabolites of Callyspongia spp. are addressed, which may lead to the development of new drugs and targeted therapeutic approaches. Several scientific databases, such as Google Scholar, PubMed, ResearchGate, Science Direct, Springer Link, and Wiley Online Library, were mined to obtain relevant information. In the 41 articles reviewed, Callyspongia spp. was reported to possess pharmacological activities such as cytotoxicity against cancer cell lines (36%), antifungal (10%), anti-inflammatory (10%), immunomodulatory (10%), antidiabetic and antiobesity (6%), antimicrobial (8%), antioxidant (4%), antineurodegenerative (4%), antihypercholesterolemic (2%), antihypertensive (2%), antiparasitic (2%), antiallergic (2%), antiviral (2%), antiosteoporotic (2%), and antituberculosis (2%) activities. Of these, the antioxidant, antituberculosis, and anti-inflammatory activities of Callyspongia extract were weaker compared with that of the control drugs; however, other activities, particularly cytotoxicity, show promise, and the compounds responsible may be developed into new drugs.
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