A Brief Analysis of Traditional Chinese Medical Elongated Needle Therapy on Acute Spinal Cord Injury and Its Mechanism

Du, Mengxuan; Chen, Rongliang; Quan, Renfu; Zeng, Liang; Xu, Jingdong; Yang, Zhong‐Bao; Yang, Disheng

doi:10.1155/2013/828754

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…These two pathways eventually converge at caspase-3, which executes apoptosis by cleaving the cytoskeleton and activating DNA-degrading enzymes. Du et al [ 36 ] documented that the penetrating acupuncture at BL54 ( Zhibian ) and ST28 ( Shuidao ) inhibited exogenous death receptor-mediated apoptosis of neurons in acute SCI and downregulated the local expression of FAS and caspase-3. Shi et al [ 37 ] showed that the elongated needle therapy at BL54 and ST28 promoted the recovery from SCI.…”

Section: The Effect Of Acupuncture On Neural Restoration In Spinalmentioning

confidence: 99%

Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects

et al. 2020

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Spinal cord injury (SCI) is a structural event with devastating consequences worldwide. Due to the limited intrinsic regenerative capacity of the spinal cord in adults, the neural restoration after SCI is difficult. Acupuncture is effective for SCI-induced neurologic deficits, and the potential mechanisms responsible for its effects involve neural protection by the inhibition of inflammation, oxidation, and apoptosis. Moreover, acupuncture promotes neural regeneration and axon sprouting by activating multiple cellular signal transduction pathways, such as the Wnt, Notch, and Rho/Rho kinase (ROCK) pathways. Several studies have demonstrated that the efficacy of combining acupuncture with mesenchymal stem cells (MSCs) transplantation is superior to either procedure alone. The advantage of the combined treatment is dependent on the ability of acupuncture to enhance the survival of MSCs, promote their differentiation into neurons, and facilitate targeted migration of MSCs to the spinal cord. Additionally, the differentiation of MSCs into neurons overcomes the problem of the shortage of endogenous neural stem cells (NSCs) in the acupuncture-treated SCI patients. Therefore, the combination of acupuncture and MSCs transplantation could become a novel and effective strategy for the treatment of SCI. Such a possibility needs to be verified by basic and clinical research.

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Section: The Effect Of Acupuncture On Neural Restoration In Spinalmentioning

confidence: 99%

Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects

et al. 2020

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Traditional Chinese Medicine comprehensive therapy for the improvement of motor function in spinal cord injury patients

Wang

Zhang

Guodong

et al. 2016

Journal of Traditional Chinese Medicine

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Anti-Apoptotic Mechanisms of Acupuncture in Neurological Diseases: A Review

Cai

Wei-dong

2018

Am. J. Chin. Med.

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Apoptosis, known as programmed cell death, plays a significant role in the pathogenesis of neurological diseases. Most of these diseases can be obviously alleviated by means of acupuncture treatment. Current research studies have shown that the efficacy of acupuncture to these medical conditions is closely associated with the anti-apoptotic potentials. Mainly based on the acupuncture's anti-apoptotic efficacy in prevalent neurological disorders, including cerebral ischemia-reperfusion injury, Alzheimer's disease, depression or stress related-modes, spinal cord injuries, etc., this review comes to a conclusion that the anti-apoptotic effect of acupuncture treatment for neurological diseases, evidently reflected through Bcl-2, Bax or caspase expression change, results from regulating mitochondrial or autophagic dysfunction as well as reducing oxidative stress and inflammation. The possible mechanisms of acupuncture's anti-apoptotic effect are associated with a series of downstream signaling pathways and the up-regulated expression of neurotrophic factors. It is of great importance to illuminate the exact mechanisms of acupuncture treatment for neurological dysfunctions.

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A Brief Analysis of Traditional Chinese Medical Elongated Needle Therapy on Acute Spinal Cord Injury and Its Mechanism

Cited by 3 publications

References 14 publications

Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects

Effects and Mechanisms of Acupuncture Combined with Mesenchymal Stem Cell Transplantation on Neural Recovery after Spinal Cord Injury: Progress and Prospects

Traditional Chinese Medicine comprehensive therapy for the improvement of motor function in spinal cord injury patients

Anti-Apoptotic Mechanisms of Acupuncture in Neurological Diseases: A Review

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