Traditional Chinese Medicine comprehensive therapy for the improvement of motor function in spinal cord injury patients

Wang, Yuanhui; Zhang, Lei; Guodong, Pan; Jing, Liu; Zhang, Hongrui; Xu, Shengyuan; Wang, Qiang

doi:10.1016/s0254-6272(16)30081-4

Cited by 4 publications

(6 citation statements)

References 15 publications

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“…Spinal cord injury is the most serious complication of spinal injury, enough to cause severe dysfunction of the limbs below the injured segment. In Chinese medicine, it is mostly seen in the category of impotence and should be treated with evidence-based medicine [35,36]. For those with weakness of both lower limbs, muscle atrophy, fatigue, lack of breath and speech, reduced diet, diarrhoea and loose stools, etc., they can follow medical advice to choose drugs that tonify the middle and vital energy, strengthen the spleen, and promote clearing [37,38].…”

Section: Discussionmentioning

confidence: 99%

Systematic Nursing Interventions Combined with Continuity of Care in Patients with a Spinal Fracture Complicated with a Spinal Cord Injury and Its Effect on Recovery and Satisfaction

Xia

Wang

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The aim of this study is to examine the application value of systematic nursing interventions combined with continuity of care in cases with a spinal fracture complicated with a spinal cord injury and its effect on recovery and satisfaction. Methods. We identified ninety cases with a spinal fracture complicated with a spinal cord injury who were admitted to local hospital from May 2019 to May 2021 as research subjects and assigned them into an experimental group (systematic nursing combined with continuity of care, n = 45) and a control group (conventional nursing, n = 45) according to their admission order. The level of life of all groups between intervention was evaluated with reference to the Generic Quality of Life Inventory-74 (GQOLI-74) Rating Scale. The Hospital Anxiety and Depression (HAD) scale was used to assess the emotional status of patients before and after intervention. The complication rates, nursing outcomes, nursing satisfaction, and rehabilitation outcomes of all cases were calculated. Results. The GQOLI-74 score of the experimental group was higher than that of another group ( P < 0.05 ). Lower HAD scores of experimental group were observed than that of another group ( P < 0.05 ). The experimental group obtained remarkably higher nursing effective rates and higher nursing satisfaction than another group ( P < 0.05 ). Rehabilitation outcome of the experimental group outperformed that another group ( P < 0.05 ). Conclusion. The use of systematic nursing intervention combined with continuity of care for cases with spinal fracture complicated with a spinal cord injury can enhance the nursing effect, effectively relieve cases’ psychological pressure, improve patients’ level of life and nursing satisfaction, and contribute to the maintenance of a good nurse-patient relationship, which merits clinical promotion.

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Section: Discussionmentioning

confidence: 99%

Systematic Nursing Interventions Combined with Continuity of Care in Patients with a Spinal Fracture Complicated with a Spinal Cord Injury and Its Effect on Recovery and Satisfaction

Xia

Wang

2022

Evidence-Based Complementary and Alternative Medicine

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“…TCM is a valuable resource of bioactive components, exhibiting anti‐inflammatory effects to protect against diseases, including SCI 10–13,30,31 . For instance, paeoniflorin, an extract from peony, has been reported to possess various biological activities in modulating the MAPK pathway to recover chronic constriction injury in rats 32 .…”

Section: Discussionmentioning

confidence: 99%

“…It is increasingly recognized that traditional Chinese medicine (TCM) has shown a promising beneficial effect on alleviating inflammatory damages after acute SCI. Along this line, the concrete mode of action for some TCMs has recently begun to be unveiled 10–13 . In an instance, Du Zhong Yao Tong Wan showed restoration function in the SCI‐induced animal model, in which one of the main components, peony (scientifically named Radix Paeoniae Alba ), could exhibit wound repairing effect 11 …”

Section: Introductionmentioning

confidence: 99%

“…Along this line, the concrete mode of action for some TCMs has recently begun to be unveiled. [10][11][12][13] In an instance, Du Zhong Yao Tong Wan showed restoration function in the SCI-induced animal model, in which one of the main components, peony (scientifically named Radix Paeoniae Alba), could exhibit wound repairing effect. 11 Further, the biochemical analysis of peony composition resulted in identifying a bioactive compound, albiflorin (AF).…”

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confidence: 99%

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Effects of albiflorin on oxidative stress and inflammatory responses in rats with acute spinal cord injury

Fang,

Wang,

Sun

et al. 2023

Immunity Inflam & Disease

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IntroductionOxidative stress and inflammatory responses are often the predominant detrimental factors associated with spinal cord injury (SCI). This study investigates the potential therapeutic effects of albiflorin (AF) on alleviating inflammation and oxidative stress in the rat model with SCI.MethodsInitially, the behavior of SCI‐induced rats is examined by Basso−Beattie−Bresnahan score and the inclined plane examination. Then, the immunohistochemical staining of inflammasome‐related protein (for instance, NACHT, LRR, and PYD domains‐containing protein 3, NLRP3) is performed in combination with enzyme‐linked immunosorbent assay (ELISA) of corresponding proinflammatory factors to assess the immunomodulatory effects of AF. Further, the markers involved in oxidative stress are examined by ELISA and western blot analysis analyses.ResultsThese findings indicated that AF could alleviate motor dysfunction and the loss of neuron cells in SCI‐induced rats. Mechanistically, AF could attenuate the inflammatory responses by reducing oxidative stress and activating nuclear erythroid‐related factor 2 (Nrf2)/heme oxygenase‐1 (HO‐1) pathway in SCI rats. Depleting the antioxidant capacity by inhibiting glutathione biosynthesis could counteract the anti‐inflammatory activity of AF in SCI rats.ConclusionsTogether, our data suggested that AF could serve as a potential therapeutic agent against the aggravation of SCI in rats.

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“…[21] According to TCM, the injury to the Governor Vessel, the stoppage of qi and blood circulation, the loss of nutrition to the bones, muscles, and bones, atrophy of the limbs, and stasis of qi and blood are the basic etiologies of this disease. [22] BYHWD, a decoction that is frequently used in TCM, has been shown to have a considerable therapeutic impact in the treatment of SCI. Its actions include tonifying qi, stimulating blood, cleansing meridians, and activating collaterals.…”

Section: Discussionmentioning

confidence: 99%

Exploring the mechanism of Buyang Huanwu Decoction in the treatment of spinal cord injury based on network pharmacology and molecular docking

Wang¹,

Chen²,

Wang³

et al. 2022

Medicine

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Buyang Huanwu Decoction, a traditional Chinese medicine decoction, is widely used to treat spinal cord injury in China. However, the underlying mechanism of this decoction in treating spinal cord injury is unclear. This study used network pharmacology and molecular docking to examine the pharmacological mechanism of Buyang Huanwu Decoction in prevention and treatment of spinal cord injury. The active compounds and target genes of Buyang Huanwu Decoction were collected from the Traditional Chinese Medicine Systems Pharmacology and the SwissTargetPrediction Database. The network diagram of ”traditional Chinese medicine compound target“ was constructed by Cytoscape software. Genetic data of spinal cord injury were obtained by GeneCards database. According to the intersection of Buyang Huanwu Decoction’s targets and disease targets, the core targets were searched. The protein-protein interaction network were constructed using the STRING and BisoGenet platforms. Meanwhile, gene ontology enrichment and Kyoto encyclopedia of genes, and genome pathway were performed on the intersection targets by Metascape. Molecular docking technology was adopted to verify the combination of main components and core targets. A total of 109 active compounds and 5440 prediction targets were screened from 7 Chinese herbal medicines of Buyang Huanwu Decoction, with 98 active components and 49 related prediction targets being strongly linked to Spinal Cord Injury. By studying protein-protein interaction network, a total of 8 core proteins were identified, primarily interleukin-6, tumor protein P53, epidermal growth factor receptor, and others. Positive regulation of kinase activity regulation of reaction to inorganic chemicals are the basic biological processes. Buyang Huanwu Decoction cures Spinal Cord Injury primarily by moderating immunological inflammation, apoptosis, and oxidative stress, which involves the cancer pathway, the HIF-1 signaling pathway, the p53 signaling pathway, the MAPK signaling pathway, and so on. The results of molecular docking demonstrated that the primary components could attach to the target protein effectively. Finally, the mechanism of Buyang Huanwu Decoction in the treatment of spinal cord injury through multicomponent, multitarget, and multichannel was deeply explored. And it offers new ideas and directions for future research on the mechanism of the treatment of spinal cord injury.

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Traditional Chinese Medicine comprehensive therapy for the improvement of motor function in spinal cord injury patients

Cited by 4 publications

References 15 publications

Systematic Nursing Interventions Combined with Continuity of Care in Patients with a Spinal Fracture Complicated with a Spinal Cord Injury and Its Effect on Recovery and Satisfaction

Systematic Nursing Interventions Combined with Continuity of Care in Patients with a Spinal Fracture Complicated with a Spinal Cord Injury and Its Effect on Recovery and Satisfaction

Effects of albiflorin on oxidative stress and inflammatory responses in rats with acute spinal cord injury

Exploring the mechanism of Buyang Huanwu Decoction in the treatment of spinal cord injury based on network pharmacology and molecular docking

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