A Brain to Spine Interface for Transferring Artificial Sensory Information

Yadav, Amol P.; Li, Daniel; Nicolelis, Miguel A. L.

doi:10.1101/807735

Cited by 1 publication

(2 citation statements)

References 59 publications

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“…However, cortical-spinal connections have also been created and show promising evidence for further application. Yadav et al demonstrated that rats could discriminate sensory information delivered by dorsal column stimulation (DCS), as evidenced by recordings from microelectrode arrays that showed this information was transmitted to the brain [62]. Given that Yadav et al stimulated the spinal cord and recorded from the brain, further research could involve spinal cord recordings paired with brain stimulation to transmit sensory information and bypass damaged neural pathways.…”

Section: Cortical ←→ Spinal Neural Bypassesmentioning

confidence: 99%

“…By utilizing optogenetics in the nucleus incertus of two mice, the mice were able to mimic locomotion with an information transfer rate of 4 bits/second [82]. Lastly, Yadav et al demonstrated a brain-to-spine interface where tactile and artificial sensory information could be decoded by the brain of one rat and delivered to the spinal cord of another rat, with the potential to transmit prosthetic information from the spinal cord to the brain or between brains/spinal cords [62].…”

Section: Inter-subject Neural Bypassesmentioning

confidence: 99%

See 1 more Smart Citation

Neural Bypasses: Literature Review and Future Directions in Developing Artificial Neural Connections

Zuccaroli¹,

Lucke‐Wold²,

Palla³

et al. 2023

OBM Neurobiol

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Reported neuro-modulation schemes in the literature are typically classified as closed-loop or open-loop. A novel group of recently developed neuro-modulation devices may be better described as a neural bypass, which attempts to transmit neural data from one location of the nervous system to another.<strong> </strong>The most common form of neural bypasses in the literature utilize EEG recordings of cortical information paired with functional electrical stimulation for effector muscle output, most commonly for assistive applications and rehabilitation in spinal cord injury or stroke. Other neural bypass locations that have also been described, or may soon be in development, include cortical-spinal bypasses, cortical-cortical bypasses, autonomic bypasses, peripheral-central bypasses, and inter-subject bypasses. The most common recording devices include EEG, ECoG, and microelectrode arrays, while stimulation devices include both invasive and noninvasive electrodes. Several devices are in development to improve the temporal and spatial resolution and biocompatibility for neuronal recording and stimulation. A major barrier to entry includes neuroplasticity and current decoding mechanisms that regularly require retraining. Neural bypasses are a unique class of neuro-modulation. Continued advancement of neural recording and stimulating devices with high spatial and temporal resolution, combined with decoding mechanisms uninhibited by neuroplasticity, can expand the therapeutic capability of neural bypassing. Overall, neural bypasses are a promising modality to improve the treatment of common neurologic disorders, including stroke, spinal cord injury, peripheral nerve injury, brain injury and more.

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Section: Cortical ←→ Spinal Neural Bypassesmentioning

confidence: 99%

Section: Inter-subject Neural Bypassesmentioning

confidence: 99%