1989
DOI: 10.1001/archneur.1989.00520420054022
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A Brain Regional Analysis of Morphologic and Cholinergic Abnormalities in Alzheimer's Disease

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Cited by 53 publications
(25 citation statements)
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“…This is also in line with the known distribution of neuropathological changes (Mann et al, 1985;Katzman et al, 1988). As found previously MRB was in general unchanged (Perry et al, 1978;Gottfries et al, 1983;Zubenko et al, 1989) indicating sparing of muscarinic receptors in AD. Although some loss of MRB can be found in most severely demented younger AD patients (Reinikainen et al, 1987b), probably due to the loss of presynaptic muscarinic receptors (Mash et al, 1985), the muscarinic postsynaptic cholinergic receptors are not clearly affected in AD thus leaving possibilities for cholinergic replacement therapy, The present study also demonstrated significant reductions in the concentrations of 5HT, SHTAA, NA and DA in the cerebral cortex, hippocampus and striatum in AD patients.…”
Section: Discussionsupporting
confidence: 89%
“…This is also in line with the known distribution of neuropathological changes (Mann et al, 1985;Katzman et al, 1988). As found previously MRB was in general unchanged (Perry et al, 1978;Gottfries et al, 1983;Zubenko et al, 1989) indicating sparing of muscarinic receptors in AD. Although some loss of MRB can be found in most severely demented younger AD patients (Reinikainen et al, 1987b), probably due to the loss of presynaptic muscarinic receptors (Mash et al, 1985), the muscarinic postsynaptic cholinergic receptors are not clearly affected in AD thus leaving possibilities for cholinergic replacement therapy, The present study also demonstrated significant reductions in the concentrations of 5HT, SHTAA, NA and DA in the cerebral cortex, hippocampus and striatum in AD patients.…”
Section: Discussionsupporting
confidence: 89%
“…When comparing the two subgroups (Table 4), biparietal and left temporo-occipital perfusion ratios were significantly lower when the age of onset of the dementia was earlier than 65 years. This is consistent with histopathological or biochemical studies that demonstrated more severe abnormalities in the pre-senile form of dementia when compared with the senile form (Wilcock and Esiri 1983;Bowen et al 1982;Yates et al 1983;Zubenco et al 1989). Nevertheless, dementia duration was significantly different between the two subgroups (Table 2), and, moreover, it was negatively correlated with MMS score as well as with left parieto temporal hypoperfusion within the whole group.…”
Section: Dementia Of the Alzheimer's Typesupporting
confidence: 86%
“…Hence it has been suggested that elevation of the acetylcholine (ACh) level might be helpful in attempts to improve the symptoms of cognitive deficits in AD [15] . Loss of cholinergic innervation, as demonstrated by reduced choline acetyltransferase (ChAT) and elevated acetylcholinesterase (AChE) activity is well correlated with the degree of dementia and severity of the neuropathological hallmarks of AD [16,17] . Therefore, NAR through its inhibitory effect on acetylcholinesterase activity could exert a mitigating effect on amnesia in experimental model of SAD.…”
Section: Discussionmentioning
confidence: 99%