Effect of Naringenin on Intracerebroventricular Streptozotocin-Induced Cognitive Deficits in Rat: A Behavioral Analysis

Baluchnejadmojarad, Tourandokht; Roghani, Mehrdad

doi:10.1159/000096585

Cited by 62 publications

(30 citation statements)

References 38 publications

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“…Increase levels of reactive oxygen species (ROS) can increase lipid peroxidation and MDA level which lead to neural cell death [21,22]. During oxidation, endogenous and exogenous oxidants react with saturated fatty acids and produce peroxides which destroy myelin sheath, lipids, genetic material and other membrane components [23].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Thymus vulgaris Extract on Hippocampal Injury Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Setorki

Mirzapoor

2017

Zahedan J Res Med Sci

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Background: A Brief interruption of blood supply to the brain can cause significant changes in the function of central nervous system. Patients usually show cognitive, emotional and electrophysiological changes during recovery from stroke. Preliminary pharmacokinetic studies have shown that Thymus vulgaris is useful in the treatment of seizures, respiratory diseases, smooth muscular spasm and bloating.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Thymus vulgaris Extract on Hippocampal Injury Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Setorki

Mirzapoor

2017

Zahedan J Res Med Sci

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“…ICV administration of STZ in rats causes long-term and progressive deficits in learning and cognitive performance that is similar to the sporadic kind of AD (Baluchnejadmojarad, 2009). STZ increases glucose in rats' brain, leads to increase processed amyloid precursor protein to beta-amyloid and intensifies the inflammatory process.…”

Section: Discussionmentioning

confidence: 93%

“…ICV administration of STZ in rats causes long-term and progressive deficits in learning and cognitive performance that are similar to the sporadic kind of AD (Baluchnejadmojarad, 2009). It appears that this drug can lead to insulin resistance in brain cells, increases glucose in the brain, and reduces the energy available to the cells (Roghani, Baluchnejadmojarad, 2006).…”

Section: Introductionmentioning

confidence: 96%

Kaempferol promotes memory retention and density of hippocampal CA1 neurons in intra-cerebroventricular STZ-induced experimental AD model in Wistar rats

Darbandi¹,

Ramezani²,

Khodagholi³

et al. 2016

biologija

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Background. Alzheimer's disease (AD) is a progressive degenerative disease which causes memory disorders, decreases cognitive functions and abilities, and results in behavioural changes. Some studies have indicated that the flavonoids are able to cross the blood-brain barrier and have a positive effect on the reduction of neuronal damage disorders in the brain such as Alzheimer's disease.Materials and Methods. ICV administration of streptozotocin (3 mg/kg) was done on the first and the third day of the surgery and the animals' memory was evaluated through passive avoidance tasks. Animals were divided into five groups: Salin-Salin, STZ-Salin, and STZ-different kaempferol doses (5, 7/5, 10 mg/kg). All animals received different doses of kaempferol or saline for 3 weeks starting one day before the surgery. Later, they were put into a learning test. After the memory test, the animals were killed and their brains were fixed with Paraformaldehyde 4%, and tissue processing was done. Finally, density of intact neurons in the CA1 area of the hippocampus in the brains of all groups was investigated.Results. The ICV injections of STZ significantly reduced memory retention and intact pyramidal cells compared to the control group. The kaempferol improved the effects of STZ.Conclusion. Our findings show that kaempferol can optimize cognitive deficits caused by injections of STZ and also has some useful impacts on hippocampal CA1 pyramidal neurons.

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“…Spatial memory were tested using a radial arm maze (RAM) according to the paradigm described previously (Bagheri et al, 2011;Baluchnejadmojarad and Roghani, 2006). The apparatus consisted of a 50-cm-elevated (above the floor) eight-armed radial maze (RAM) made of black Plexiglas.…”

Section: Ram Taskmentioning

confidence: 99%

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

Ghofrani

Joghataei

Mohseni

et al. 2015

European Journal of Pharmacology

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148

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Alzheimer's disease (AD) is one of the prevalent neurological disorders of the central nervous system hallmarked by increased beta-amyloid (Aβ) deposition and ensuing learning and memory deficit. In the present study, the beneficial effect of naringenin on improvement of learning and memory was evaluated in an Alzheimer's disease rat model. The Aβ-injected rats showed a lower alternation score in Y-maze task, impairment of retention and recall capability in passive avoidance test, and lower correct choices and higher errors in radial arm maze (RAM) task as compared to sham group in addition to enhanced oxidative stress and apoptosis. Naringenin, but not a combination of naringenin and fulverstrant (an estrogenic receptor antagonist) significantly improved the performance of Aβ-injected rats in passive avoidance and RAM tasks. Naringenin pretreatment of Aβ-injected rats also lowered hippocampal malondialdehyde (MDA) with no significant effect on nitrite and superoxide dismutase (SOD) activity in addition to lowering apoptosis. These results suggest naringenin pretreatment attenuates Aβ-induced impairment of learning and memory through mitigation of lipid peroxidation and apoptosis and its beneficial effect is somewhat mediated via estrogenic pathway.

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Effect of Naringenin on Intracerebroventricular Streptozotocin-Induced Cognitive Deficits in Rat: A Behavioral Analysis

Cited by 62 publications

References 38 publications

Evaluation of Thymus vulgaris Extract on Hippocampal Injury Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Evaluation of Thymus vulgaris Extract on Hippocampal Injury Induced by Transient Global Cerebral Ischemia and Reperfusion in Rat

Kaempferol promotes memory retention and density of hippocampal CA1 neurons in intra-cerebroventricular STZ-induced experimental AD model in Wistar rats

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

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