A botanical and pharmacological description of petasites species

Tys, J.; Szopa, Aleksandra; Lalak, Justyna; Chmielewska, Mariola; Serefko, Anna; Poleszak, Ewa

doi:10.1515/cipms-2015-0062

Cited by 7 publications

(7 citation statements)

References 32 publications

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“…To observe the effect on cell viability of Butterbur root extract we used an MTT assay based on the conversion of tetrazolium salt from oxidoreductase enzymes to insoluble formazan (colour compound) and measurement of the absorption intensity of staining as described by Mosmann [18]. MDA-MB-231, MCF-7 and L929 cells were treated with different concentrations of BE (2,4,8,40,200,250, 500, 1000 and 5000 μg/mL) for 72 h. After the incubation time 20 μL of 5 mg/mL of MTT ((3-(4,5-dimethylthiazol-2-yl)-2,5-diphe nyltetrazolium bromide) Merck, Germany) reagent were added to each well in 96-well plates. The cells were incubated for 3 h at 37 °C.…”

Section: Mtt Assaymentioning

confidence: 99%

“…Representatives of genus Petasites contain high levels of bioactive substances with promising therapeutic potential [1]. Studies have shown that they exhibit anti-inflammatory, analgesic, antioxidant, diuretic, anti-spasmodic, anti-tumour and other activities [1,2]. Among many secondary metabolites of the species of this genus such as polyphenol acids, flavonoids, lignans, thanines and small concentrations of pyrrolizidine alkaloids, the pharmacological effects are mainly attributed to eremophilane type sesquiterpenes and sesquiterpene lactones [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…The Petasites extracts are successfully used for the prevention of gastric ulcer, urinary tract irritation and respiratory problems [2]. They also find an increasingly widespread pharmacological application for the prophylaxis and treatment of migraine and tension headaches, bronchial asthma and allergic rhinitis -diseases affecting a large number of people [7].…”

Section: Introductionmentioning

confidence: 99%

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Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines

Tzoneva

Uzunova

Stoyanova

et al. 2021

Biotechnology & Biotechnological Equipment

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In this study, we present initial data for the potential anti-cancer effects of standardized Bulgarian Petasites hybridus root extract against breast cancer cells. The results showed that Butterbur extract (BE) caused a dose-dependent selective reduction in viability with concomitant increase of apoptosis in human breast cancer cells after 72 h treatment. We found the highest cytotoxicity of BE to MDA-MB-231 cells (IC 50 -520 μg/mL), followed by the MCF-7 cancer cell line (IC 50 -865 μg/mL). At the same time, the extract exhibited very low cytotoxicity to the non-tumorigenic L929 cell line (two-fold higher inhibitory concentration -1252 μg/mL). As a result of our experiments we made the conclusion that Butterbur root extract shows selective high cytotoxicity and nucleus alterations in cancer cells comparing to non-cancerous cells.

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Section: Mtt Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines

Tzoneva

Uzunova

Stoyanova

et al. 2021

Biotechnology & Biotechnological Equipment

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“…The primary inflorescence is a flower head, while the secondary inflorescence is a raceme. The petioles are light grey, fuzzy and hollow and the plant possesses thick rhizomes (Sakai et al 2008;Tys et al 2015).…”

Section: Petasites Japonicusmentioning

confidence: 99%

Fukinolic acid and cimicifugic acids: a review

Jahn

Petersen

2021

Phytochem Rev

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During the last decades, the research on the biological activities of extracts from Cimicifuga/Actaea species and Petasites japonicus as well as their active ingredients has been intensified. Besides terpenoids as dominant natural product group, hydroxycinnamic acid esters such as fukinolic acid and several cimicifugic acids have been isolated from Actaea and Petasites species and their chemical structures have been elucidated. Investigations on the biological properties of these hydroxycinnamic acid esters are currently undertaken and some compounds might be promising therapeutic tools. In this review, we have gathered information on the genera Actaea and Petasites, the occurrence of cimicifugic and fukinolic acids and some aspects of their biosynthesis. Furthermore, we have summarized the medicinal aspects of fukinolic acid and cimicifugic acids. In connection with the biological activities of these compounds, structural features of the hydroxycinnamic acid derivatives move into the focus. The position of the hydroxyl group at the aromatic rings and the introduction of an electron-donating moiety may be important for anti-inflammatory, antiviral, cytotoxic and vasoactive effects of these compounds.

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“…Moreover, its effects on chronic diseases have been demonstrated, suggesting its utility as a functional food. Studies have reported the physiological functions of P. hybridus ; ( 14 , 15 ) however, to the best of our knowledge, no review articles have particularly focused on the physiological functions of P. japonicus . Therefore, in this review, the functions of P. japonicus are summarized, as they may be useful for the development of potential functional foods.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant compounds of <i>Petasites japonicus</i> and their preventive effects in chronic diseases: a review

Hiemori-Kondo

2020

J. Clin. Biochem. Nutr.

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Petasites japonicus ( P. japonicus ) is a plant of the Asteraceae family. Its roots and stems have been used for the treatment or the prophylaxis of migraine and tension headache as a traditional Chinese medicine in Japan and Korea. Sesquiterpenoids, lignans, and flavonoids are components of P. japonicus . Regarding the biological activity of P. japonicus , its anti-allergic effect has been researched extensively using IgE antigen-stimulated degranulation of RBL-2H3 cells or passive cutaneous anaphylaxis reaction in experimental animal models. The study of the antioxidant activity of P. japonicus was initiated approximately 15 years ago using in vitro assays. In addition, its in vivo effect has also been examined in animal models with induced oxidative injury. Moreover, recently, many types of antioxidant compounds have been rapidly and simultaneously identified using the liquid chromatography–mass spectrometry technique. The number of reports on the other functions of this plant, such as its neuroprotective and anti-inflammatory effects, has been increasing. In this review, I summarized the studies of functional foods derived from P. japonicus , which may provide a basis for the development of potential functional foods. Finally, I discuss the future research avenues in this field.

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A botanical and pharmacological description of petasites species

Cited by 7 publications

References 32 publications

Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines

Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines

Fukinolic acid and cimicifugic acids: a review

Antioxidant compounds of <i>Petasites japonicus</i> and their preventive effects in chronic diseases: a review

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