A bioresorbable biomaterial carrier and passive stabilization device to improve heart function post-myocardial infarction

Duffy, Garry P.; Hofmann, Björn B.; Vaal, Michael Hamman de; Bellavia, Gabriella; Straino, Stefania; Kovářová, Lenka; Pravda, Martin; Velebný, Vladimı́r; Daro, D.; Braun, Nathalie; Monahan, David S.; Levey, Ruth E.; O’Neill, Hugh; Hinderer, Svenja; Greensmith, Robert; Monaghan, Michael G.; Schenke‐Layland, Katja; Dockery, Peter; Murphy, Bruce P.; Kelly, Helena; Wildhirt, Stephen M.

doi:10.1016/j.msec.2019.109751

Cited by 26 publications

(24 citation statements)

References 86 publications

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“…Slides were imaged using Ocularâ2.0 Imaging Software on an Olympus BX41 Microscope with Olympus U-AN360P analyzer under a 20x objective lens. Quantification of the collagen content was performed using a previously reported technique (58,59). For immunohistochemical analysis, primary antibodies of CD31 (ab28364, Abcam) (1:200), CD68 (MCA341, Bio Rad) (1:300) and α-SMA (ab5694, Abcam) (1:100) were incubated for 1 hour at 37 °C.…”

Section: Microct Histological and Immunohistochemical Analysismentioning

confidence: 99%

An actuatable soft reservoir modulates host foreign body response

et al. 2019

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The performance of indwelling medical devices that depend on an interface with soft tissue is plagued by complex, unpredictable foreign body responses. Such devices—including breast implants, biosensors, and drug delivery devices—are often subject to a collection of biological host responses, including fibrosis, which can impair device functionality. This work describes a milliscale dynamic soft reservoir (DSR) that actively modulates the biomechanics of the biotic-abiotic interface by altering strain, fluid flow, and cellular activity in the peri-implant tissue. We performed cyclical actuation of the DSR in a preclinical rodent model. Evaluation of the resulting host response showed a significant reduction in fibrous capsule thickness (P = 0.0005) in the actuated DSR compared with non-actuated controls, whereas the collagen density and orientation were not changed. We also show a significant reduction in myofibroblasts (P = 0.0036) in the actuated group and propose that actuation-mediated strain reduces differentiation and proliferation of myofibroblasts and therefore extracellular matrix production. Computational models quantified the effect of actuation on the reservoir and surrounding fluid. By adding a porous membrane and a therapy reservoir to the DSR, we demonstrate that, with actuation, we could (i) increase transport of a therapy analog and (ii) enhance pharmacokinetics and time to functional effect of an inotropic agent. The dynamic reservoirs presented here may act as a versatile tool to further understand, and ultimately to ameliorate, the host response to implantable biomaterials.

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Section: Microct Histological and Immunohistochemical Analysismentioning

confidence: 99%

An actuatable soft reservoir modulates host foreign body response

et al. 2019

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“…Resorbable PUs, owing to their tunable mechanical properties and easy complexing with other materials, have been deployed for a variety of applications in vivo to determine basic compatibility for soft tissue repair, 53,155,156 cartilage and bone repair, 157,158 cardiac tissue engineering 159 and wound healing. 160 The studies were conducted using mouse, rat, rabbit and pig models, and spanned observation periods ranging between 2 and 16 weeks.…”

Section: Discussionmentioning

confidence: 99%

Resorbable elastomers for implantable medical devices: highlights and applications

Turner

Ramesh

Menegatti

et al. 2021

Polymer International

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Resorbable elastomers are an emerging class of materials required for transient implantable medical devices (IMDs), as their tissue‐matching mechanical properties decrease the risks associated with implant removal and promote functional tissue integration. Traditional materials employed in IMDs are typically much more rigid than native tissue, which leads to increased foreign body response and tissue irritation, and must be removed at the end of life of the implant, thus increasing the risk to patients. Resorbable elastomeric biomaterials support efficiently all the functions of substrate/encapsulant, dielectric, semiconductors and conductors that are needed in IMDs, while offering beneficial mechanical properties and a programed degradation that circumvents the need for surgical removal. This mini‐review presents the chemical characteristics, material properties and applications as IMD substrates of three resorbable elastomer families: polyurethane, poly(glycerol sebacate) and poly(diol citrate). Finally, some challenges and future directions on the pathway to biomedical adoption of resorbable elastomeric biomaterials are discussed including safety, processing conditions and critical development steps for conductive and dielectric elastomers. © 2021 Society of Industrial Chemistry.

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“…As a result, much effort is being made to engineer a delivery approach which considers material properties while being minimally invasive. One such example is the novel epicardial carrier device namely Surface Prone EpicArdial Delivery System (SPREADS) 166 designed by Dolan et al The device consists of 2 layers: an outer porous foam layer and an electrospun permeable inner layer. The middle part of the foam formed a bulge structure which contained the hydrogel.…”

Section: Injectability Of Hydrogelsmentioning

confidence: 99%