A bioinspired ionic liquid tagged cobalt-salophen complex for nonenzymatic detection of glucose

Ionic liquids for addressing unmet needs in healthcare

“…Early advances were motivated to develop ILs as green, nonvolatile, nonflammable, and stable solvents, however, recent findings have broadened the field, redefining ILs as low melting salts (melting point <100°C) with an unlimited suite of tunable properties including toxicity, volatility, flammability, and instability . The erstwhile narrow perspective that views ILs as salts of quaternary ammonium, imidazolium, pyrrolidinium, pyridinium, or phosphonium cations has broadened as new cations including the bioinspired cholinium and guanidinium cations as well as metal‐containing cations are paired with various anions to afford salts that meet the definition of IL (Figure ). The evolving complexity of the precursors fosters a conjecture that explains their characteristically low melting point by the structural heterogeneity of a sterically hindered asymmetric cation that impedes strong ionic interaction with the anion as well as precludes ordered packing within a crystal lattice.…”

“…Incorporating a metal center into an organic molecule integrates the unique magnetic, photo‐activity, and redox‐activity of metals with the inherent stability and processibility of organic molecules . Toward this direction, metal‐containing ILs are emerging as counterparts of purely organic‐based ILs with the intent of imparting new functions to liquid salts . This development challenges the concept of ILs as organics salts as the realm opens to organometallic and coordination chemistry.…”

“…Some reports on the synthesis of metal‐containing ILs exist in the literature, but knowledge about their applications is scarce. However, recently, Senthilkumar and coworkers reported a cobalt (Co)‐containing salophen‐type IL for the nonenzymatic sensing of glucose . Glucose sensing forms an integral element in the management of diabetes mellitus, a metabolic disorder that kills 1.5 million people in 2012 worldwide because of elevated blood glucose level that causes life‐threatening issues .…”

“…Glucose sensing forms an integral element in the management of diabetes mellitus, a metabolic disorder that kills 1.5 million people in 2012 worldwide because of elevated blood glucose level that causes life‐threatening issues . In contrast to enzyme‐based glucose sensors, the metal‐based nonenzymatic technology is cheap, robust, and easy to fabricate, making it an attractive option in the quest for new glucose biosensors . The ability to tune the redox activity of a transition metal via selection of an appropriate ligand endows this emerging technology with a flexibility that is absent in the enzyme‐based technology.…”

The functionality of the hybrid systems driven by molecular dimension of the guest copper Schiff‐base complexes entrapped in Zeolite‐Y

“…In this direction heterogenization of the homogeneous catalyst is a convenient approach to couple the reactivity of the complex with the stability, specific environment and ease of separation provided by host materials. Impregnation and encapsulation of transition metal complexes in the microporous, mesoporous materials and MOFs, homogeneous catalyst tagged with ionic liquids, alumina‐supported metal complexes and phase transfer catalyst are some interesting examples of heterogeneous systems, which have been successfully employed in the various oxidation reactions by using H 2 O 2 , TBHP, and molecular O 2 as oxidants . Zeolites, the microporous aluminosilicate materials are the competent hosts for the encapsulation of transition metal complexes having the molecular dimension comparable with the diameter cavities of the host zeolites .…”