Ionic liquids for addressing unmet needs in healthcare

Agatemor, Christian; Ibsen, Kelly N.; Tanner, Eden E. L.; Mitragotri, Samir

doi:10.1002/btm2.10083

Cited by 131 publications

(88 citation statements)

References 121 publications

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“…. ILs have shown great promise for transdermal drug delivery including delivery of small molecules and proteins . Our lab showed that a choline and geranic acid based IL, referred to as CAGE ( Figure ), has shown to be effective in the transdermal delivery of insulin as well as small molecule antimicrobial agents …”

Section: Molecular Properties Of the Carboxylic Acids Used To Create mentioning

confidence: 99%

Design Principles of Ionic Liquids for Transdermal Drug Delivery

et al. 2019

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Ionic liquids (ILs) and deep eutectic solvents have shown great promise in drug delivery applications. Choline‐based ILs, in particular choline and geranic acid (CAGE), have been used to enhance the transdermal delivery of several small and large molecules. However, detailed studies outlining the design principles of ILs for transdermal drug delivery are still lacking. Using two model drugs of differing hydrophilicities, acarbose and ruxolitinib and 16 ILs, the dependence of skin penetration on the chemical properties of ILs is examined. First, the impact of ion stoichiometry on skin penetration of drugs is assessed using CAGE, which evidences that a molar ratio of 1:2 of choline to geranic acid yields the highest delivery. Subsequently, variants of CAGE are prepared using anions with structural similarity to geranic acid and cations with structural similarity to choline at a ratio of 1:2. Mechanistic studies reveal that the potency of ILs in enhancing transdermal drug delivery correlates inversely with the inter‐ionic interactions as determined by 2D NMR spectroscopy. Using this understanding, a new IL is designed, and it provides the highest delivery of ruxolitinib of all ILs tested here. Overall, these studies provide a generalized framework for optimizing ILs for enhancing skin permeability.

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Section: Molecular Properties Of the Carboxylic Acids Used To Create mentioning

confidence: 99%

Design Principles of Ionic Liquids for Transdermal Drug Delivery

et al. 2019

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“…Because they can be tuned for specific applications by simple alterations in their ionic components, ILs are widely used in the chemical industry in a variety of roles including catalysts and solvents [44]. This tuneability, coupled with the fact that ILs have been shown to affect biological systems including plants, animals and microbial life, has also made them important in biotechnology [45,46]. Understanding how ILs affect different species allows researchers to tailor them for a variety of roles including drug synthesis or drug delivery [45][46][47].…”

Section: Introductionmentioning

confidence: 99%

“…This tuneability, coupled with the fact that ILs have been shown to affect biological systems including plants, animals and microbial life, has also made them important in biotechnology [45,46]. Understanding how ILs affect different species allows researchers to tailor them for a variety of roles including drug synthesis or drug delivery [45][46][47]. For example, ILs can improve drug solubility and increase absorption [48,49].…”

Section: Introductionmentioning

confidence: 99%

Investigating the potential use of an ionic liquid (1-Butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide) as an anti-fungal treatment against the amphibian chytrid fungus, Batrachochytrium dendrobatidis

et al. 2020

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The disease chytridiomycosis, caused by the pathogenic chytrid fungus, Batrachochytrium dendrobatidis (Bd), has contributed to global amphibian declines. Bd infects the keratinized epidermal tissue in amphibians and causes hyperkeratosis and excessive skin shedding. In individuals of susceptible species, the regulatory function of the amphibian's skin is disrupted resulting in an electrolyte depletion, osmotic imbalance, and eventually death. Safe and effective treatments for chytridiomycosis are urgently needed to control chytrid fungal infections and stabilize populations of endangered amphibian species in captivity and in the wild. Currently, the most widely used anti-Bd treatment is itraconazole. Preparations of itraconazole formulated for amphibian use has proved effective, but treatment involves short baths over seven to ten days, a process which is logistically challenging, stressful, and causes long-term health effects. Here, we explore a novel anti-fungal therapeutic using a single application of the ionic liquid, 1-Butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide (BMP-NTf2), for the treatment of chytridiomycosis. BMP-NTf2 was found be effective at killing Bd in vitro at low concentrations (1:1000 dilution). We tested BMP-NTf2 in vivo on two amphibian species, one that is relatively tolerant of chytridiomycosis (Pseudacris regilla) and one that is highly susceptible (Dendrobates tinctorius). A toxicity trial revealed a surprising interaction between Bd infection status and the impact of BMP-NTf2 on D. tinctorius survival. Uninfected D. tinctorius tolerated BMP-NTf2 (mean ± SE; 96.01 ± 9.00 μl/g), such that only 1 out of 30 frogs died following treatment (at a dose of 156.95 μL/g), whereas, a lower dose (mean ± SE; 97.45 ± 3.52 μL/g) was not tolerated by Bd-infected D. tinctorius,

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“…19,20 Papers on medical devices included control algorithms for artificial pancreas. 21 Along with original research articles, we also published reviews on some of the active current topics in translational medicine including ionic liquids for biomedical applications, 22 clinical landscape of nanomedicine, 23 and translational status of nanocrystals. 24 Thank you all for your strong support to the journal and look forward to your continued support in coming years.…”

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confidence: 99%

Bioengineering & Translational Medicine: Year 2020 in review

Mitragotri

2020

Bioengineering & Transla Med

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Huge thanks to all BioTM authors who trusted the journal with their precious manuscripts in the early, unproven days. Submission of high-quality manuscripts is the principal reason that led to an impressive launching impact factor. BioTM welcomes manuscripts in all aspects of bioengineering including drug delivery, drug discovery and development, tissue engineering, synthetic biology, biosensors, organoids and organ-mimetic systems, stem cell therapies, gene therapies, immunotherapies, patient-targeted therapies, medical devices, regenerative medicine, implant/patient interface, computational modeling, and bioinformatics. Areas including drug delivery, gene therapy, sirRNA delivery, regenerative medicine, nanomedicine, biomedical devices, and cell therapy have been particularly well represented in the manuscripts recently submitted to BioTM. This is expected because these fields represent some of the most active research areas at the interface of medicine and engineering, especially those that focus on developing/

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Ionic liquids for addressing unmet needs in healthcare

Cited by 131 publications

References 121 publications

Design Principles of Ionic Liquids for Transdermal Drug Delivery

Design Principles of Ionic Liquids for Transdermal Drug Delivery

Investigating the potential use of an ionic liquid (1-Butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide) as an anti-fungal treatment against the amphibian chytrid fungus, Batrachochytrium dendrobatidis

Bioengineering & Translational Medicine: Year 2020 in review

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