A biochemical research focused on the association of the levels of oxidative stress and nitric oxide with premalignant disorders and oral squamous cell carcinoma

Sachdev, Rohan; Garg, Kriti; Mehrotra, Vishal; Shwetam, Samiksha; Saxena, Shubhra; Srivastava, Akash

doi:10.4103/njms.njms_160_20

Cited by 2 publications

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Through in-depth genomic analyses, researchers can uncover genetic changes, disrupted signaling pathways, and epigenetic alterations associated with oxidative stress-induced oral carcinogenesis. From another angle, Sachdev et al [ 99 ] highlighted the importance of exploring ways to support antioxidant systems in people with oral cancer. By considering these directions for future research and taking advantage of technologies such as genomics and proteomics, scientists could answer more questions and significantly advance the field.…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in the Pathogenesis of Oral Cancer

Ionescu,

Kamal,

Ciobica

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Oxidative stress, arising from an imbalance between reactive oxygen species (ROS) and antioxidants, contributes significantly to oral cancer such as oral squamous cell carcinoma (OSCC) initiation, promotion, and progression. ROS, generated both internally and externally, induce cellular damage including DNA mutations and lipid peroxidation, fostering oncogene activation and carcinogenesis. The objective of this review was to cover and analyze the interplay between ROS and antioxidants, influencing the key processes such as cell proliferation, apoptosis, and angiogenesis, shaping the trajectory of OSCC development. Despite the promise of antioxidants to halt cancer progression and mitigate oxidative damage, their therapeutic efficacy remains debated. The conducted literature search highlighted potential biomarkers that indicate levels of oxidative stress, showing promise for the early detection and monitoring of OSCC. Furthermore, melatonin has emerged as a promising adjunct therapy for OSCC, exerting antioxidant and oncostatic effects by modulating tumor-associated neutrophils and inhibiting cancer cell survival and migration. In addition, this review aims to shed light on developing personalized therapeutic strategies for patients with OSCC such as melatonin therapy, which will be discussed. Research is needed to elucidate the underlying mechanisms and clinical implications of oxidative stress modulation in the context of oral cancer.

show abstract

Section: Discussionmentioning

confidence: 99%