A bio-amplifier with pulse output

Chen, Du; Harris, John G.; Prı́ncipe, José C.

doi:10.1109/iembs.2004.1404136

Cited by 16 publications

(8 citation statements)

References 12 publications

(11 reference statements)

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“…Typical neural action potential signals from extracellular recording have frequency components in the range of 0.1 Hz -10 KHz with amplitudes in range of 50 -500 μV [14]. As a result, amplification is needed before any further signal processing.…”

Section: Neural Signal Amplifiersmentioning

confidence: 99%

Low power integrated circuits for wireless neural recording applications

Zhang

Gui

Chen

2008

APCCAS 2008 - 2008 IEEE Asia Pacific Conference on Circuits and Systems

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A group of prototype integrated circuits are presented for a wireless neural recording micro-system. An inductive link was built for transcutaneous wireless power transfer and data transmission. Power and data were transmitted by a pair of coils on a same carrier frequency. The integrated receiver circuitry was composed of a full-wave bridge rectifier, a voltage regulator, a date recovery circuit, a clock recovery circuit and a power detector. The amplifiers were designed with a limited bandwidth for neural signals acquisition. An integrated FM transmitter was used to transmit the extracted neural signals to external equipments. 16.5 mW power and 50 bps -2.5 Kbps command data can be received over 1 MHz carrier within 10 mm. The total gain of 60 dB was obtained by the preamplifier and a main amplifier at 0.95Hz -13.41 KHz with 0.215 mW power dissipation. The power consumption of the 100 MHz ASK transmitter is 0.374 mW. All the integrated circuits operated under a 3.3 V power supply except the voltage regulator.

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Section: Neural Signal Amplifiersmentioning

confidence: 99%

Low power integrated circuits for wireless neural recording applications

Zhang

Gui

Chen

2008

APCCAS 2008 - 2008 IEEE Asia Pacific Conference on Circuits and Systems

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“…DC gain is therefore defined by the ratio of the shunting resistance and the parallel resistance of the electrode. Another fully integrated approach suggests using a pseudo-resistor device based on a weak inversion MOS and a parasitic bipolar [27], [19], [28], [12]. Such a device has an extremely large small signal resistance at small bias voltages.…”

Section: Input Preampmentioning

confidence: 99%

An Integrated System for Multichannel Neuronal Recording With Spike/LFP Separation, Integrated A/D Conversion and Threshold Detection

Perelman

Ginosar

2007

IEEE Trans. Biomed. Eng.

104

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Abstract-A mixed-signal front-end processor for multichannel neuronal recording is described. It receives twelve differential-input channels of implanted recording electrodes. A programmable cutoff HPF blocks DC and low frequency input drift at about 1Hz. The signals are band-split at about 200Hz to low-frequency local field potential (LFP) and high-frequency spike data (SPK), which is band limited by a programmablecutoff LPF, in a range of 8-13kHz. Amplifier offsets are compensated by 5-bit calibration DACs. The SPK and LFP channels provide variable amplification rates of up to 5000 and 500, respectively. The analog signals are converted into 10-bit digital form, and streamed out over a serial digital bus at up to 8Mbps. A threshold filter suppresses inactive portions of the signal and emits only spike segments of programmable length. A prototype has been fabricated on a 0.35µm CMOS process and tested successfully, demonstrating a 3µV noise level. Special interface system incorporating an embedded CPU core in a programmable logic device accompanied by real-time software has been developed to allow connectivity to a computer host.

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“…[8] However, nearly all currently known bioamplifier circuits are designed to drive a separate ADC block, with the exception of [9] which produces pulse delay modulated output. Thus, there are two primary sources of power and complexity in the typical analog front-end.…”

Section: Introductionmentioning

confidence: 99%

Micropower integrated bioamplifier and auto-ranging ADC for wireless and implantable medical instrumentation

Cauwenberghs

2010

2010 Proceedings of ESSCIRC

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Abstract-A micropower, high-resolution biopotential data acquisition circuit for wireless and implantable medical instrumentation is presented. The circuit is an incremental ∆Σ (BioADC) that accepts inputs directly from recording electrodes and serves as both amplifier and digitizer with just a single OTA at the core. Auto-ranging and precise digital gain control allow the BioADC to accommodate input ranges of 1mV to 30mV with DC offset rejection. The hybrid amplifier/ADC achieves up to 12 bits of resolution, a sampling rate of 2.048kHz and an input referred noise of 2.65µV rms at a power consumption of 20µW . The bioamplifier achieves a noise efficiency factor of 3.1. Live physiological ECG data are shown, acquired by connecting passive Ag/AgCl electrodes directly to the BioADC input.

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A bio-amplifier with pulse output

Cited by 16 publications

References 12 publications

Low power integrated circuits for wireless neural recording applications

Low power integrated circuits for wireless neural recording applications

An Integrated System for Multichannel Neuronal Recording With Spike/LFP Separation, Integrated A/D Conversion and Threshold Detection

Micropower integrated bioamplifier and auto-ranging ADC for wireless and implantable medical instrumentation

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