A bibliometric analysis of PIN1 and cell death

Abstract

Background: Regulation of cell death plays a key role in numerous diseases. As a proline isomerase, prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) is important for the regulation of signaling pathways. An in-depth understanding of how Pin1 participates in the process of cell death, which affects the occurrence and development of diseases, will aid in the discovery of new disease mechanisms and therapeutic methods. Thus, the purpose of our study was to discover the research trends and hotspots of Pin1 and cell death through bibliometric analyses and to provide insights for understanding the future development of basic research and treatment of diseases.Methods: Documents were extracted from the Web of Science Core Collection on 7 May 2022. We selected articles and reviews published in English from 2000 to 2021, and visual and statistical analyses of countries, institutions, authors, references and keywords were performed using VOSviewer 1.6.18 and CiteSpace 5.8.Results: A total of 395 articles and reviews were selected. Since 2001, the number of articles on Pin1 and cell death has increased annually. Publications come from 43 countries, with the US having the most publications and citations. We identified 510 authors, with Giannino Del Sal having the most articles and Paola Zacchi having the most co-citations. The Journal of Biological Chemistry is the most researched journal, and Nature and its subjournals are the most cited journals. Apoptosis, phosphorylation, and breast cancer were the three most common keywords.Conclusion: The number of documents showed an increasing trend from 2001 to 2014. Stagnant growth after 2014 may be related to the absence of new research hotspots. Cooperative links between core institutions need to be strengthened, and the institution with the highest citation count in recent years is Fujian Medical University in China. The role of Pin1 in cell death requires further research to discover new research hotspots. Before breakthroughs in molecular mechanism or signaling pathway research, future research will focus more on the treatment of diseases represented by Pin1 inhibitors.

The molecular mechanisms of peptidyl-prolyl cis/trans isomerase Pin1 and its relevance to kidney disease

“…This Pin1-autophagy relationship has also been observed in senescent auditory hair cells, where Pin1 inhibition leads to LC3 upregulation and p62 downregulation ( Lv et al, 2022 ). While changes in GSK3αβ expression levels have no impact on cadmium-induced Pin1 levels in HepG2, the inhibition of GSK-3β in mouse livers leads to Pin1 activation, suggesting that GSK-3β might mediate the role of Pin1 in autophagy ( Zhang J. H. et al, 2022 ; Chao et al, 2022 ). Additionally, in tamoxifen-resistant breast cancer, elevated levels of Pin1 enhance its interaction with p-MEK1/2, resulting in increased E2F-4- and Egr-1-driven LC-3 expression ( Namgoong et al, 2010 ).…”

“…Pin1, also known as Protein NIMA 1, is an 18 kDa protein that belongs to the parvulin subfamily ( Zhao et al, 2016 ). Numerous studies have demonstrated that Pin1-mediated isomerization plays a pivotal role in various biological processes, including the cell cycle, cell proliferation, apoptosis, signal transduction, transcription and splicing, immune response, and maintenance of the cytoskeleton ( Esnault et al, 2007 ; Yeh and Means, 2007 ; Akiyama et al, 2009 ; Zhang J. H. et al, 2022 ). Furthermore, dysregulation of Pin1 is closely linked to the onset and progression of various diseases.…”

Bibliometric analysis of PTEN in neurodevelopment and neurodegeneration

“…Compared with reviews, bibliometric analyses, which use mathematical and statistical methods, can evaluate publication quality, citation burst, and scholarly impact, thereby reflecting the current state of related research information (Chen et al, 2020;Shah et al, 2021;Creager et al, 2022;Zhang JH et al, 2023). This discipline can also provide new researchers who aim to enter the field of research with the most fundamental and influential research studies (Yan et al, 2022;Zhang et al, 2022). CiteSpace and VOSviewer are two popular visual software packages for analysis that can help bibliometric researchers arrange large quantities of disordered data into an objective and rigorous network diagram (Yan et al, 2021;Wang and Maniruzzaman, 2022;Zheng et al, 2022).…”

A bibliometric analysis of apoptosis in glaucoma

“…Compared to a review in general, bibliometric analysis is a mathematically and statistically feasible discipline to summarize and predict current and future research hotspots and trends by evaluating specific research areas based on main authors, research institutes, journals, citation frequency, keywords, etc (Hu et al, 2022 ; Zhang et al, 2022 ). CiteSpace and VOSviewer are two common and important bibliometric analysis software (Chen et al, 2022a ; Zhang et al, 2022 ; Zhao et al, 2022 ). By using them alone or in combination, we obtain a better analysis of research trends and hotspots according to different specifications (Romero and Portillo-Salido, 2019 ; Zhao et al, 2022 ).…”