A 7-day profile of oxidative stress and antioxidant status in patients with acute liver failure

Bhatia, Vikram; Bhardwaj, Pradeep; Elikkottil, Jessina; Batra, Jyoti; Saraya, Anoop

doi:10.1007/s12072-008-9098-6

Cited by 15 publications

(12 citation statements)

References 32 publications

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“…The release of necrotic products into the circulation might trigger a systemic inflammatory response . In patients with acute liver failure, a high level of oxidative stress is observed . Moreover, a novel and accurate marker of oxidative stress, advanced oxidation protein, has been shown to participate in activation of monocytes and neutrophils, which aggravate inflammation and induce liver injury via mitochondrial dysfunction .…”

Section: Discussionmentioning

confidence: 99%

Neutrophil–lymphocyte ratio: a novel predictor for short‐term prognosis in acute‐on‐chronic hepatitis B liver failure

Liu

Zhang

et al. 2013

Journal of Viral Hepatitis

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Acute-on-chronic hepatitis B liver failure (ACHBLF) has a poor prognosis in patients with hepatitis B virus infection. The role of the neutrophil-lymphocyte ratio (NLR), which reflects the inflammatory status of the patient before treatment, has never been studied in this setting. To investigate the predictive value of NLR in patients with ACHBLF, a retrospective cohort with 216 patients and a prospective validation cohort with 73 patients were recruited. Multivariate analyses showed that total bilirubin (TBIL), NLR, age and model for end-stage liver disease (MELD) score had prognostic significance for survival. Both NLR (0.781) and MELD score (0.744) had higher ROC curves, which differed significantly from those for age (0.615) and TBIL (0.691), but not from each other (P = 0.94). NLR ≤ 2.36 predicted lower mortality (with 91.6% sensitivity and 86.0% negative predictive value), and NLR >6.12 was a warning sign for higher mortality risk (with 90.1% specificity and 80.3% positive predictive value). These results demonstrated that pretreatment NLR was associated with the prognosis of patients with ACHBLF, and elevated NLR predicted poor outcome within 8 weeks. We suggest that NLR cut-offs of ≤ 2.36 and >6.12 are powerful markers for predicting mortality in ACHBLF.

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Section: Discussionmentioning

confidence: 99%

Neutrophil–lymphocyte ratio: a novel predictor for short‐term prognosis in acute‐on‐chronic hepatitis B liver failure

Liu

Zhang

et al. 2013

Journal of Viral Hepatitis

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“…Bhatia et al . observed patients with acute liver failure for about 7 days and found that there was a high level of oxidative stress in these patients 22 . Emerging data suggested that acetaminophen (APAP)‐induced hepatic failure was associated with mitochondrial dysfunction due to oxidative stress, 23 which aggravated inflammation and induced liver injury.…”

Section: Discussionmentioning

confidence: 99%

Monitoring oxidative stress in acute‐on‐chronic liver failure by advanced oxidation protein products

Liu

Han

Tian

et al. 2011

Hepatology Research

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“…The inability of the liver to fulfill its normal physiological function can result in acute or chronic hepatic failure. Acute hepatic failure (AHF) is hallmarked by a rapid and immense necrosis and hepatocyte apoptosis . Underlying causes of AHF are mainly drug‐induced liver toxicity or viral hepatitis .…”

Section: Clinical Conditions Stimulating Eryptosis By Generation Of Omentioning

confidence: 99%

“…Oxidative stress not only damages cellular components like DNA, proteins or lipids, but also causes the release of proinflammatory cytokines leading to hepatic fibrosis, inflammation and cirrhosis . The dying hepatocytes are also a source of oxidative stress causing further destruction of hepatocytes and release of ROS, thus, establishing a vicious circle . In the various forms of liver disease, ROS are mainly produced in the mitochondria and endoplasmic reticulum by cytochrome P450 enzymes, a process occurring in hepatocytes, Kupffer cells and neutrophils (Fig.…”

Section: Clinical Conditions Stimulating Eryptosis By Generation Of Omentioning

confidence: 99%

Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases

et al. 2018

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The average lifespan of circulating erythrocytes usually exceeds hundred days. Prior to that, however, erythrocytes may be exposed to oxidative stress in the circulation which could cause injury and trigger their suicidal death or eryptosis. Oxidative stress activates Ca -permeable nonselective cation channels in the cell membrane, thus, stimulating Ca entry and subsequent cell membrane scrambling resulting in phosphatidylserine exposure and activation of Ca -sensitive K channels leading to K exit, hyperpolarization, Cl exit, and ultimately cell shrinkage due to loss of KCl and osmotically driven water. While the mechanistic link between oxidative stress and anemia remains ill-defined, several diseases such as diabetes, hepatic failure, malignancy, chronic kidney disease and inflammation have been identified to display both increased oxidative stress as well as eryptosis. Recent compelling evidence suggests that oxidative stress is an important perpetrator in accelerating erythrocyte loss in different systemic conditions and an underlying mechanism for anemia associated with these pathological states. In the present review, we discuss the role of oxidative stress in reducing erythrocyte survival and provide novel insights into the possible use of antioxidants as putative antieryptotic and antianemic agents in a variety of systemic diseases.

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A 7-day profile of oxidative stress and antioxidant status in patients with acute liver failure

Abstract: A high level of systemic oxidative stress exists in ALF, with depletion of antioxidant reserves. Further studies are needed to define the clinical correlation of the large pro-oxidant burden.

Cited by 15 publications

References 32 publications

Neutrophil–lymphocyte ratio: a novel predictor for short‐term prognosis in acute‐on‐chronic hepatitis B liver failure

Neutrophil–lymphocyte ratio: a novel predictor for short‐term prognosis in acute‐on‐chronic hepatitis B liver failure

Monitoring oxidative stress in acute‐on‐chronic liver failure by advanced oxidation protein products

Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases

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