Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases

Bissinger, Rosi; Bhuyan, Abdulla Al Mamun; Qadri, Syed M.; Läng, Florian

doi:10.1111/febs.14606

Cited by 148 publications

(130 citation statements)

References 281 publications

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“…Through its effects on the membrane of RBCs (i.e., lipid peroxidation and protein oxidation) and caspase 3 activation (93, 94), oxidative stress is a key modulator of RBC rheological properties. Moreover, oxidative stress is able to activate Ca 2+ -permeable non-selective cation channels in the RBC membrane, leading to the accumulation of Ca 2+ within RBCs, which can trigger RBC membrane scrambling, resulting in phosphatidylserine exposure and possibly in membrane bubbling and emission of MPs (95). In addition, the activation of Ca 2+ -sensitive K + channels can lead to K + exit, hyperpolarization, Cl − exit and cell shrinkage (95).…”

Section: Oxidative Stress and Rbcsmentioning

confidence: 99%

“…Moreover, oxidative stress is able to activate Ca 2+ -permeable non-selective cation channels in the RBC membrane, leading to the accumulation of Ca 2+ within RBCs, which can trigger RBC membrane scrambling, resulting in phosphatidylserine exposure and possibly in membrane bubbling and emission of MPs (95). In addition, the activation of Ca 2+ -sensitive K + channels can lead to K + exit, hyperpolarization, Cl − exit and cell shrinkage (95). Baskurt et al (96) demonstrated that superoxide anion caused a decrease in RBC deformability, a slight decrease in RBC aggregation and a large increase in RBC aggregates strength, meaning that the RBC aggregates formed are more robust upon oxidative stress.…”

Section: Oxidative Stress and Rbcsmentioning

confidence: 99%

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The Red Blood Cell—Inflammation Vicious Circle in Sickle Cell Disease

2020

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Section: Oxidative Stress and Rbcsmentioning

confidence: 99%

Section: Oxidative Stress and Rbcsmentioning

confidence: 99%

The Red Blood Cell—Inflammation Vicious Circle in Sickle Cell Disease

2020

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“…Недавнее исследование продемонстрировало, что анемия у пациентов с артритом должна, по крайней мере частично, вызывать усиленный эриптоз [58]. Увеличенный эриптоз сравним с усиленным окислительным стрессом и повышенным показателем внутриклеточных ионов Ca 2+ [56]. Заманчиво предположить, что увеличенное прилипание эриптозных эритроцитов к клеткам эндотелия сосудов может способствовать патофизиологии сосудистой окклюзии и ишемии у пациентов с артритом.…”

Section: эриптоз как элемент патогенеза анемииunclassified

“…Продолжительность жизни эритроцитов человека составляет от 100 до 120 дней. Старение эритроцитов -это естественный процесс, изучению которого посвящено много исследований, последние достижения в этой области отражены в ряде обзорных работ [1,56,179,241].…”

Section: Introductionunclassified

Eryptosis (quasi-apoptosis) the human red blood cells. Its role in medicinal therapy

Vaschenko

Иванович²,

Vilyaninov

et al. 2019

Rev Clin Pharm Drug Ther

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In the course of circulation erythrocytes can test damages, which compromises their integrity and thus triggers suicidal erythrocyte death or eryptosis. This mechanism is characterised by cell shrinkage, cell membrane blebbing, and cell membrane phospholipid scrambling after phosphatidylserine exposure on the cell surface that is identified by macrophages, which engulf and degrade the eryptotic cells. The term eryptosis also includes typical mechanisms, which contribute to the triggering of this process, such as oxidative stress, Ca2+ entry with an increase in cytosolic Ca2+ activity and the activation of p38 kinase, which is a kinase expressed in human erythrocytes and activated after hyperosmotic shock. Enhanced eryptosis has been observed in several clinical conditions such as diabetes, renal insufficiency, haemolytic uremic syndrome, sepsis, mycoplasma infection, malaria, iron deficiency, sickle cell anaemia, beta-thalassemia, glucose-6-phosphate dehydrogenase (G6PD)-deficiency, hereditary spherocytosis, paroxysmal nocturnal haemoglobinuria, Wilson’s disease, myelodysplastic syndrome, and phosphate depletion. Therefore, eryptosis may be considered as a useful mechanism of removal of defective erythrocytes to prevent haemolysis. Moreover, the clearance of infected erythrocytes in diseases such as malaria may counteract parasitemia. Indeed it is known that sickle-cell trait, beta-thalassemia trait, G6PD-deficiency and iron deficiency confer some protection against a severe course of malaria. Importantly, strategies to control Plasmodium infection by inducing eryptosis are not expected to generate resistance of the pathogen, as the proteins involved in suicidal death of the host cell are not encoded by the pathogen and thus cannot be modified by mutations of its genes. However, excessive eryptosis could compromise microcirculation and lead to anemia. Besides, adhesion of eryptosis erythrocytes to a vascular wall also can lead to microcirculation infringement.Thus, modern representations about eryptosis expand our knowledge about the programmed death of blood cells and is more directed to create new therapeutic schemes of treatment of patients.

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“…In addition, the therapeutic effects of erythropoietin are often limited due to iron deficiency in the hemodialysis patients (12). Given the high impact of oxidative stress on accelerating blood cell destruction and exacerbating anemia, especially in chronic conditions, new therapeutic approaches have been directed toward the use of antioxidants as potential agents in the improvement of anemia (13).…”

Section: Introductionmentioning

confidence: 99%

The effect of thyme honey on anemia in hemodialysis patients

Kiasari

Nobahar

Ghorbani

et al. 2020

NPT

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Background & Aim: Anemia is one of the most common complications of chronic renal failure, which is associated with increased fatigue, dyspnea, depression, malaise, prolonged hospitalization and mortality. Some patients are resistant to erythropoietin therapy. Therefore, the purpose of this study was to determine the effect of thyme honey on anemia in hemodialysis patients. Methods & Materials: The present clinical trial was conducted in 2018 at Kowsar Hospital of Semnan on hemodialysis patients randomly selected with convenience sampling method within two groups of case (n=28) and control (n=27). The case group received thyme honey (33 g) daily for one month. The control group did not consume thyme honey. Blood samples were taken from the patients before and after the intervention with 10-hour fasting and then blood parameters were assessed. Results: The mean ±SD reduction rate in hemoglobin level was 0.46±0.96 in the case group and 0.23±3.15 g/dl in the control group, but no significant difference using independent t-test (P=0.758). The mean±SD reduction rate in hematocrit percentages was 1.20±2.78 in the case group and 0.11±8.53 in the control group, but there is no significant difference between the two groups using independent t-test (P=0.590). Conclusion: Results showed that daily administration of 33 grams of thyme honey had no effect on anemia in hemodialysis patients. Further studies are recommended with modification of the methodology regarding the type, dose, duration and instructions of honey consumption for better results.

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Oxidative stress, eryptosis and anemia: a pivotal mechanistic nexus in systemic diseases

Cited by 148 publications

References 281 publications

The Red Blood Cell—Inflammation Vicious Circle in Sickle Cell Disease

The Red Blood Cell—Inflammation Vicious Circle in Sickle Cell Disease

Eryptosis (quasi-apoptosis) the human red blood cells. Its role in medicinal therapy

The effect of thyme honey on anemia in hemodialysis patients

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